Abstract: Disclosed herein are compositions that comprise engineered polynucleotides, pharmaceutical compositions comprising the same, methods of making the same, and methods of treatment comprising the compositions that comprise the engineered polynucleotides.

Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.

Abstract: Disclosed herein include methods, compositions, and kits suitable for use in calcium imaging. There are provided, in some embodiments, Ca2+-sensing GvpC proteins. Disclosed herein include Ca2+-sensing gas vesicles (GVs) comprising Ca2+-sensing GvpC proteins. In some embodiments, the Ca2+-sensing GvpC protein is capable of undergoing a first allosteric conformational change upon the Ca2+-binding domain binding Ca2+ that causes the Ca2+-sensing GV to change from a GV stiff state to a GV soft state. One or more of the mechanical, acoustic, surface, and magnetic properties of a Ca2+-sensing GV can differ between the GV soft state and the GV stiff state.

Abstract: Disclosed herein are compositions that comprise engineered polynucleotides, pharmaceutical compositions comprising the same, methods of making the same, and methods of treatment comprising the compositions that comprise the engineered polynucleotides.

Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.

Abstract: Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site.

Abstract: Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site.

Abstract: Provided herein are engineered protease sensitive gas vesicles and related engineered protease genetically GvpC constructs, vectors, gas vesicles gene clusters, genetic circuits, cells, compositions, methods and systems, which in several embodiments can be used together with contrast-enhanced imaging technique, to detect and report protease activity and related biological events in an imaging target site.

Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.

Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.

Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.

Abstract: Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site.

Abstract: A user equipment (UE) performs a transform domain (DFT) based method to detect the cyclic prefix (CP) length that is being used by a base station for cellular communications. The detected CP length is then used to reduce the amount of time required to complete the synchronization and cell search procedures. In particular, the UE uses the detected CP length information to obtain Cell Identification parameters (NID1, NID2) along with information including a Maximum energy Tap location and a reference signal receive power (RSRP) while completing the synchronization and cell search procedures.

Abstract: The invention provides ultra-small peptide inhibitors that are capable of preventing amyloid formation/amyloidosis.

Abstract: A user equipment (UE) performs a transform domain (DFT) based method to detect the cyclic prefix (CP) length that is being used by a base station for cellular communications. The detected CP length is then used to reduce the amount of time required to complete the synchronization and cell search procedures. In particular, the UE uses the detected CP length information to obtain Cell Identification parameters (NID1, NID2) along with information including a Maximum energy Tap location and a reference signal receive power (RSRP) while completing the synchronization and cell search procedures.

Abstract: A user equipment (UE) performs a transform domain (DFT) based method to detect the cyclic prefix (CP) length that is being used by a base station for cellular communications. The detected CP length is then used to reduce the amount of time required to complete the synchronization and cell search procedures. In particular, the UE uses the detected CP length information to obtain Cell Identification parameters (NID1, NID2) along with information including a Maximum energy Tap location and a reference signal receive power (RSRP) while completing the synchronization and cell search procedures.

Abstract: A method and apparatus of determining a hand-off metric are disclosed. One method includes a subscriber receiving identifications of a neighboring set of base stations from a serving base station, determining an active set of base stations by measuring received signal power from each of the base stations of the neighboring set at first discrete points in time, averaging the received signal power for each of these base stations, and selecting the active set based on the average received signal power. Determining the hand-off metric further includes calculating a ratio of average receive signal power to average excess received signal power, for each base station of the active set, wherein the excess received signal power includes signal power received by the subscriber in excess of power received from the base station.

Abstract: A transmitter including a signal generator to generate an analytic signal in frequency domain, having frequency components that when converted to time domain result in a time domain signal with a preamble that includes a first half of containing non zero information and a second half containing only zero data. A shaper configured to generate a cyclic prefix including only zero data based on the second half of the preamble included in the time domain signal, and to attach the cyclic prefix including only zero data to the time domain signal to output a pilot signal that is to be transmitted via an antenna.

Abstract: A method and apparatus of determining a hand-off metric are disclosed. One method includes a subscriber receiving identifications of a neighboring set of base stations from a serving base station, determining an active set of base stations by measuring received signal power from each of the base stations of the neighboring set at first discrete points in time, averaging the received signal power for each of these base stations, and selecting the active set based on the average received signal power. Determining the hand-off metric further includes calculating a ratio of average receive signal power to average excess received signal power, for each base station of the active set, wherein the excess received signal power includes signal power received by the subscriber in excess of power received from the base station.

Abstract: A method and apparatus of determining a hand-off metric is disclosed. One method includes a subscriber receiving identifications of a neighboring set of base stations from a serving base station. From the neighboring set, the subscriber determines an active set of base stations. The active set is determined by the subscriber measuring received signal power from each of the base stations of the neighboring set at first discrete points in time, averaging the received signal power for each of the base stations of the neighboring set, and selecting the active set based on the average received signal power of the base stations of the neighboring set. Determining the at least one hand-off metric further includes the subscriber measuring at second discrete points in time an excess received signal power for each base station of the active set, wherein the excess received signal power includes signal power received by the subscriber in excess of power received from the base station.