Abstract: The invention features a computer-implemented biological data prediction method executed by one or more processors including receiving, by the one or more processors, a biomedical data set comprising biomedical data corresponding to a plurality of detected analytes in a biological sample collected from a set of patients at intermittent time intervals, the biomedical data set having a first plurality of feature dimensions; processing, by the one or more processors, the biomedical data set to generate a low-rank tensor having a second plurality of feature dimensions, wherein the second plurality of feature dimensions can be lower than the first plurality of feature dimensions; generating, by the one or more processors, predicted biomedical data along the second plurality of feature dimensions corresponding to the intermittent time intervals; and creating a reconstructed biomedical data set including the predicted biomedical data and the biomedical data along the first plurality of feature dimensions.

Abstract: The invention features a computer-implemented biological data classification method executed by one or more processors and including receiving, by the one or more processors, a first biological data set comprising a first plurality of biological sample data collected from a set of patients; processing, by the one or more processors, the first biological data set using a first variational autoencoder (VAE) to generate a first trained VAE comprising a first latent space vector of the first biological data set comprising a plurality of values corresponding to each latent space dimension of the latent space vector, the latent space vector having lower dimensionality than the biological sample data set; receiving, by the one or more processors, a second biological data set comprising a second plurality of biological sample data collected from a patient, different from the set of patients; and generating, by the one or more processors, a latent space representation of the second biological data set based on a first

Abstract: A system, including an optical imaging assembly configured to image a sample at an object plane to an image plane; an image sensor arranged at the image plane and configured to capture images of the sample for a field of view of the system; a light source configured to emit light having a wavelength, ?; a spatial light modulator (SLM) arranged to receive the light emitted from the light source and to provide a spatially modulated light pattern; one or more optical elements arranged to receive the spatially modulated light pattern from the SLM and to direct the spatially modulated light pattern to the image plane; and an electronic controller in communication with the image sensor and the spatial light modulator, the electronic controller being programmed to identify one or more targets in the field of view of the optical imaging assembly and to control the spatial light modulator to selectively direct light from the light source to the one or more targets identified by the electronic controller.

Abstract: Disclosed herein is an intradermal needle device including a rigid base; a needle rigidly affixed to the rigid base, the needle including a hollow shaft extending from the rigid base along an axis to a tip of the needle; a cap formed from a deformable material affixed to the rigid base and extending along the axis, the cap comprising a cushion portion surrounding a portion of the hollow shaft, the cushion portion having a convex-shaped surface facing away from the rigid base, wherein the tip of the needle extends beyond the convex surface by a non-zero distance of 1.5 mm or less and wherein when the intradermal needle device can be pressed with the needle tip against skin of a living body, the tip pierces the skin to a depth of 1.5 mm or less and the convex-shaped surface of the cushion portion deforms against the skin surrounding the needle.

Abstract: A system, including an optical imaging assembly configured to image a sample at an object plane to an image plane; an image sensor arranged at the image plane and configured to capture images of the sample for a field of view of the system; a light source configured to emit light having a wavelength, ?; a spatial light modulator (SLM) arranged to receive the light emitted from the light source and to provide a spatially modulated light pattern; one or more optical elements arranged to receive the spatially modulated light pattern from the SLM and to direct the spatially modulated light pattern to the image plane; and an electronic controller in communication with the image sensor and the spatial light modulator, the electronic controller being programmed to identify one or more targets in the field of view of the optical imaging assembly and to control the spatial light modulator to selectively direct light from the light source to the one or more targets identified by the electronic controller.

Abstract: A system, method, and computer readable media are provided for obtaining a first set of skin data from an image capture system including at least one ultraviolet (UV) image of a user's skin. Performing a correction on the skin data using a second set of skin data associated with the user. Quantifying a plurality of skin parameters of the user's skin based on the first skin data, including quantifying a bacterial load. Quantifying the bacterial load by applying a brightness filter to isolate portions of the at least one UV image containing fluorescence, applying a dust filter, identifying portions of the at least one UV image that contain fluorescence due to bacteria, and determining a quantity of bacterial load in the users skin. Determining, using a machine learning model, an output associated with a normal skin state of the user and a current skin state of the user.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium for skin health monitoring including instructions that, when executed, cause the one or more processors to perform various operations. The operations include obtaining first scan data representing a first hyperspectral scan of a user's skin at a first time. The operations include obtaining second scan data representing one or more previous hyperspectral scans of the user's skin during a period of time prior the first time. The operations include determining, based on providing the first scan data and the second scan data as input features to a machine learning model, a likelihood that the user will develop a predicted skin condition in the future. The operations include providing, for display on a user computing device associated with the user, information about the predicted skin condition.

Abstract: An apparatus for analysis of interstitial fluid, the apparatus including an array of needles spaced apart from each other; an array of chambers separated from each other and each in fluid communication with a lumen of a corresponding one of the needles, the array of chambers comprising one or more first chambers and one or more second chambers, the one or more first chambers each containing nanoparticles functionalized to bind with a first biomarker present in the interstitial fluid, the one or more second chambers each containing nanoparticles functionalized to bind with a second biomarker present in the interstitial fluid, the first and second biomarkers being different; and an optical sensor array positioned to simultaneously detect light emitted from each of the one or more first and second chambers in response to the first or second biomarkers binding with the nanoparticles.

Abstract: A phone may be used to conduct physiological measurements such as heart rate, respiration rate, and arterial oxygen saturation level measurements. A mobile app may be installed on a user's portable electronic device, and may direct the user to place a part of the user's body onto a user-facing optical detector such as a camera. The portable electronic device may transmit at least two light signals to the body part using the portable electronic device's screen as an emission source. Reflections of the light signals are recorded by the optical detector. Based on the reflected light signal, the portable electronic device may determine the absorption of different light frequencies and the physiological parameter values.

Abstract: A system, method, and computer readable media are provided for obtaining a first set of skin data from an image capture system including at least one ultraviolet (UV) image of a user's skin. Performing a correction on the skin data using a second set of skin data associated with the user. Quantifying a plurality of skin parameters of the user's skin based on the first skin data, including quantifying a bacterial load. Quantifying the bacterial load by applying a brightness filter to isolate portions of the at least one UV image containing fluorescence, applying a dust filter, identifying portions of the at least one UV image that contain fluorescence due to bacteria, and determining a quantity of bacterial load in the users skin. Determining, using a machine learning model, an output associated with a normal skin state of the user and a current skin state of the user.

Abstract: This disclosure describes compositions and methods for delivering nutrients (e.g., nitrogen) to plants.

Abstract: Methods of detecting and quantifying concentrations of a target molecule in a sample include determining the concentration of a displaced oligonucleotide strand.