Patents by Inventor Anurag Rathore

Anurag Rathore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the Preparation of Growth Hormone and Antagonist Thereof Having Lower Levels of Isoform Impurities Thereof
    Publication number: 20100021966
    Abstract: The present invention is directed generally to recombinant methods for making a desired polypeptide. These method(s) yield a polypeptide product containing reduced levels of isoform impurities thereof. In particular, the present invention is directed to (1) a recombinant method for preparing growth hormone with reduced isoform impurities thereof and (2) a recombinant method for preparing a growth hormone antagonist, such as pegvisomant, and its protein intermediate, also having reduced isoform impurities thereof. More specifically, the isoform impurities that are decreased by methods of the present invention are the trisulfide and des-phe isoform impurities of growth hormone and growth hormone antagonist (or its intermediate), respectively.
    Type: Application
    Filed: March 17, 2009
    Publication date: January 28, 2010
    Inventors: Anurag Rathore, Stephen B. Lyle, David E. Steinmeyer, Scott I. Allen, John Meyer, Denis M. Boyle, John J. Buckley, Gary V. Johnson
  • Process for decreasing aggregate levels of pegylated protein
    Publication number: 20050085631
    Abstract: The present invention is directed generally to recombinant methods for making a desired pegylated protein and pooling of same. These method(s) yield a polypeptide product containing reduced levels of aggregate thereof pooled to provide the desired pegylated isoforms thereof.
    Type: Application
    Filed: September 22, 2003
    Publication date: April 21, 2005
    Applicant: Pharmacia Corporation
    Inventors: Denis Boyle, John Buckley, Gary Johnson, David Steinmeyer, Michele Toal, Serdar Aykent, Anurag Rathore
  • Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
    Publication number: 20040048315
    Abstract: The present invention is directed generally to recombinant methods for making a desired polypeptide. These method(s) yield a polypeptide product containing reduced levels of isoform impurities thereof. In particular, the present invention is directed to (1) a recombinant method for preparing growth hormone with reduced isoform impurities thereof and (2) a recombinant method for preparing a growth hormone antagonist, such as pegvisomant, and its protein intermediate, also having reduced isoform impurities thereof. More specifically, the isoform impurities that are decreased by methods of the present invention are the trisulfide and des-phe isoform impurities of growth hormone and growth hormone antagonist (or its intermediate), respectively.
    Type: Application
    Filed: August 25, 2003
    Publication date: March 11, 2004
    Applicant: Pharmacia Corporation
    Inventors: Anurag Rathore, Stephen B. Lyle, David E. Steinmeyer, Scott I. Allen, John Meyer, Denis M. Boyle, John J. Buckley, Gary V. Johnson