Patents by Inventor Archana Rajesh Krishnan

Archana Rajesh Krishnan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable expression system for eukaryotic cells
    Patent number: 9752159
    Abstract: The present invention related to a polynucleotide sequence and an expression vector comprising at least one gene encoding a stress resistance protein, at least one gene encoding a selection marker, at least one gene encoding an expression protein, at least one matrix attachment region and a transcription terminator, all of which are operably connected to each other. The present invention further relates to a host cell comprising the expression vector. The present invention also relates a method of producing a cell line.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: September 5, 2017
    Assignee: BIOGENOMICS LIMITED
    Inventors: Archana Rajesh Krishnan, Sanjay Madhukar Sonar, Damodar Krishnabahadur Thappa
  • Codon optimized sequence for an antiviral protein
    Patent number: 9644015
    Abstract: A codon optimized nucleic acid sequence for Interferon Alpha-2a is provided which can be used for expression of Interferon Alpha-2a in E. Coli.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: May 9, 2017
    Assignee: BIOGENOMICS LIMITED
    Inventors: Archana Rajesh Krishnan, Sanjay Madhukar Sonar, Damodar Krishnabahadur Thappa
  • PROCESS FOR RENATURATION OF POLYPEPTIDES
    Publication number: 20160060291
    Abstract: The invention relates to method of refolding of proteins from a solution containing the protein in predominantly misfolded, aggregated form. The method involves denaturation and reduction of the protein of interest. The denatured and reduced preparation is subjected to removal of reducing agent in denaturing condition and at low pH to prevent the misfolding of the protein. The protein preparation is subjected to refolding followed by removal of the refolding buffer components.
    Type: Application
    Filed: March 28, 2013
    Publication date: March 3, 2016
    Applicant: BioGenomics Limited
    Inventors: Archana Rajesh KRISHNAN, Sanjay Madhukar SONAR
  • STABLE EXPRESSION SYSTEM FOR EUKARYOTIC CELLS
    Publication number: 20150118754
    Abstract: The present invention related to a polynucleotide sequence and an expression vector comprising at least one gene encoding a stress resistance protein, at least one gene encoding a selection marker, at least one gene encoding an expression protein, at least one matrix attachment region and a transcription terminator, all of which are operably connected to each other. The present invention further relates to a host cell comprising the expression vector. The present invention also relates a method of producing a cell line.
    Type: Application
    Filed: April 1, 2013
    Publication date: April 30, 2015
    Applicant: BioGenomics Limited
    Inventors: Archana Rajesh Krishnan, Sanjay Madhukar Sonar, Damodar Krishnabahadur Thappa
  • CODON OPTIMIZED SEQUENCE FOR AN ANTIVIRAL PROTEIN
    Publication number: 20150105537
    Abstract: A codon optimized nucleic acid sequence for Interferon Alpha-2a is provided which can be used for expression of Interferon Alpha-2a in E. Coli.
    Type: Application
    Filed: March 28, 2013
    Publication date: April 16, 2015
    Applicant: BIOGENOMICS LIMITED
    Inventors: Archana Rajesh Krishnan, Sanjay Madhukar Sonar, Damodar Krishnabahadur Thappa