Abstract: The present disclosure relates to compositions comprising compounds or cells able to specifically bind immunoglobulin kappa (IgKappa) and membrane molecule CD 19 under physiological conditions. In particular, the disclosure relates to a combinatorial chimeric antigen receptor (cCAR) with antigen binding domains specific for the antigen CD19 and the immunoglobulin (Ig) Kappa light chain and their expression in immune effector cells to target cells expressing CD19 and IgKappa, and such immune cells for use in treating B-cell cancers.

Abstract: A tool can include a substrate with a support surface and at least one mechanical registration feature. The tool can also include a removable wear material including a matrix material. The removable wear material can include a matrix material shaped to be received by the at least one mechanical registration feature of the substrate. The removable wear material can be attached to the substrate so that the at least one mechanical registration feature registers the removable wear material.

Abstract: The present invention relates to nucleic acid molecules encoding chimeric antigen receptors (CARs) against the antigen CD37. The CARs disclosed herein have complementarity-determining regions (CDRs) derived from the potent monoclonal anti-CD37 antibody HH1, and may be used in immunotherapy to target cells expressing CD37. Such immunotherapy has a particular use in the treatment of B-cell cancers. The CARs of the present invention are highly functional in the redirection of immune cells to kill CD37+ cells, and include humanised CARs of particular use in medical therapy. The present invention also includes vectors comprising the above-described nucleic acid molecules, immune effector cells expressing the aforementioned CARs and the use of such immune effector cells in therapy, particularly adoptive transfer therapy, for cancer, including B-cell malignancies.

Abstract: A tool can include a substrate with a support surface and at least one mechanical registration feature. The tool can also include a removable wear material including a matrix material. The removable wear material can include a matrix material shaped to be received by the at least one mechanical registration feature of the substrate. The removable wear material can be attached to the substrate so that the at least one mechanical registration feature registers the removable wear material.

Abstract: A technique facilitates the dependable, long-lasting use of a downhole component coupled into a drill string. In some applications, the downhole component comprises a stabilizer having a plurality of blades extending outwardly from a body, e.g. sleeve. Various features of the downhole component enhance the usefulness and dependability of the downhole component. Examples of such features comprise uniquely shaped surfaces; materials with a desired hardness, toughness, and impact strength; and/or wear protection elements incorporated into the downhole component.

Abstract: A locking ring positioned between first and second components. The locking ring includes a body having first and second opposing axial surfaces and a bore formed axially therethrough. A recess is formed into the second axial surface. The recess is defined by an outer radial surface, first and second opposing circumferentially offset surfaces, and an inner axial surface disposed between the first and second axial surfaces. At least a portion of the first circumferentially offset surface is oriented at an angle between 30° and 85° with respect to a plane that is perpendicular to a longitudinal centerline through the body.

Abstract: A locking ring may be adapted to be positioned between first and second components. The locking ring may include a body having a bore formed axially therethrough. A blade may be disposed on an outer radial surface of the body. At least a portion of a centerline through the blade may be oriented at an angle from about 1° to about 60° with respect to a centerline through the body. A recess, a protrusion, or both may be formed in an outer axial surface of the body.

Abstract: In a system for transmitting specifications for a customized prosthesis, particularly a surgical implant such as a femur prosthesis, an order is first transmitted comprising clinical data for a patient from a client (12) to a server (10). Diagnostic information for the patient is then transmitted from a diagnosis unit (13) to the server (10). The information is further transmitted to a processing unit (15), which generates inetr alia a prosthesis design draft. The draft is transmitted to the server (10) and on to the client (12). A specification based on the draft is transmitted from the client (12) to the server, and manufacturing parameters based on the specification are transmitted to a manufacturing unit (14) for manufacture of the prosthesis. The invention relates to methods and devices that form part of such a system on the server and client sides. The invention brings increased efficiency, reliability and interactivity to the process of specification and manufacture of customized prostheses.

Abstract: The present invention provides a method of cleaving an antigen/anti-antigen or hapten/anti-hapten linkage joining two particles comprising reacting said linkage with a secondary antibody, or fragment thereof, binding to said anti-antigen or anti-hapten, and a kit for performing such a method. The method of the invention has particular utility in the separation of cells.