Abstract: The present invention relates to substances and compositions thereof useful in the control of cancer stem cell persistence and concomitant tumor recurrence and/or control of tumor growth. In particular, the invention relates to substances and compositions useful in the treatment of cancers and/or tumors linked to cancer stem cells, preferably brain cancers and/or tumors, in a subject.

Abstract: The present invention is directed to the use of macrocyclic lactones, in particular avermectins, in the treatment of conditions whose formation, occurrence, development or growth is associated with aberrant Wnt signalling, in particular the treatment of colorectal cancer.

Abstract: The present invention relates to substances and compositions thereof useful in the control of cancer stem cell persistence and concomitant tumor recurrence and/or control of tumor growth. In particular, the invention relates to substances and compositions useful in the treatment of cancers and/or tumors linked to cancer stem cells, preferably brain cancers and/or tumors, in a subject.

Abstract: The present invention is directed to the use of macrocyclic lactones, in particular avermectins, in the treatment of conditions whose formation, occurrence, development or growth is associated with aberrant Wnt signalling in particular the treatment of colorectal cancer.

Abstract: The present invention relates to compounds, small interfering RNAs and compositions and methods of inhibiting tumorigenesis and methods of inhibiting tumor cell growth and proliferation using agents that inhibit the hedgehog and Gli signaling pathway, including agents that inhibit GLI synthesis and/or function. The present invention also relates to particular biomarkers that can be used in the diagnosis and prognosis of prostate cancer. Methods of treating cancer, including prostate cancer are also provided using small organic compounds, siRNAs and blocking antibodies that inhibit or block the SHH/GLI pathway.

Abstract: A metal recycling separator comprising a shredder having a sloped shaking table disposed entirely within the shredder. The shredder shreds materials into ferrous and non-ferrous materials and the sloped shaking table disperses the ferrous and non-ferrous materials onto a first conveyor belt. Non-ferrous materials are separated from ferrous materials by conveying such through two drum electromagnets, wherein the ferrous material and the remaining non-ferrous materials are transferred to a water receptacle. The water receptacle is filled with water, wherein a part of the remaining non-ferrous materials float out of the water receptacle, and the remaining ferrous materials sink to the bottom of the water receptacle. The ferrous materials and residual non-ferrous materials are then conveyed out of the water receptacle and onto two conveyor belts and a third drum electromagnet. Ferrous material is removed from the two conveyor belts and is also removed via the third drum electromagnet.

Abstract: The present invention relates to compounds, small interfering RNAs and compositions and methods of inhibiting tumorigenesis using agents that inhibit the sonic hedgehog and GLI signaling pathway, including agents that inhibit GLI expression, synthesis and/or function. The present invention also relates to particular biomarkers that can be used in the diagnosis and prognosis of cancer. Methods of treating cancer, including glioblastomas, medulloblastomas, basal cell carcinomas, prostate cancer and small cell and non-small cell lung cancer are also provided using small organic compounds, siRNAs and blocking antibodies that inhibit or block the SHH/GLI pathway.

Abstract: The present invention relates to compounds, small interfering RNAs and compositions and methods of inhibiting tumorigenesis and methods of inhibiting tumor cell growth and proliferation using agents that inhibit the hedgehog and Gli signaling pathway, including agents that inhibit GLI synthesis and/or function. The present invention also relates to particular biomarkers that can be used in the diagnosis and prognosis of melanomas. Methods of treating cancer, including melanoma are also provided using small organic compounds, siRNAs and blocking antibodies that inhibit or block the SHH/GLI pathway. In addition, the use of agents that inhibit other signaling pathways is contemplated for use as second agents to be used in conjunction with the inhibitors of the GLI pathway.

Abstract: The present invention discloses methods of producing neuronal cells from stem cells, particularly from adult brain stem cells. The use of such neuronal cells in the treatment and/or prevention of neurological diseases, conditions and/or injuries is also disclosed. In addition, the present invention provides a novel source of neuronal cells for use as a laboratory tool.

Abstract: The invention relates to a connection terminal for the connection of an electrical conductor, comprising a conducting connecting strip and a clamping spring, the spring comprising a bearing branch connected by an elbow to a clamping branch designed to clamp the conductor against a clamping portion of the strip, the strip having a first surface facing the elbow of the spring and a second surface opposite the first surface. The spring comprises at least one bearing hook designed to bear on the second surface of the strip opposite the first surface of the strip facing the elbow of the spring.

Abstract: Low-voltage electrical device comprising a spring terminal The invention relates to a low-voltage electrical device comprising an insulating body and at least one spring terminal housed in the insulating body, the insulating body having a first opening for the insertion of a conductor intended to be connected in the terminal and a second opening for the insertion of a tool intended to collaborate with the spring of the terminal to allow the conductor to be inserted into and/or removed from the terminal.

Abstract: A device for locating electric conductor cables that includes a sleeve designed to engage at least one end of a cable. The outer surface of the sleeve includes marks for identifying the cable concerned. The sleeve is flattened, and a section of the sleeve is closed over only a part of the length of the sleeve and at least part of the width of said sleeve, an unclosed part delimiting a passage for the cable.

Abstract: The inventions concerns a device comprising a sleeve designed to be engaged on a cable and whereof the outer surface includes marks for identifying the cable concerned. The sleeve is flattened, and a section of the sleeve is closed over at least part of the width of said sleeve, the unclosed part delimiting a passage for the cable.

Abstract: The present invention discloses methods of producing neuronal cells from stem cells, particularly from adult brain stem cells. The use of such neuronal cells in the treatment and/or prevention of neurological diseases, conditions and/or injuries is also disclosed. In addition, the present invention provides a novel source of neuronal cells for use as a laboratory tool.

Abstract: The present invention discloses methods of producing neuronal cells from stem cells, particularly from adult brain stem cells. The use of such neuronal cells in the treatment and/or prevention of neurological diseases, conditions and/or injuries is also disclosed. In addition, the present invention provides a novel source of neuronal cells for use as a laboratory tool.

Abstract: The invention concerns a device with a conductive core (10a) and an insulating sheath (10b) comprising a stripping and retaining slot (18). It comprises: a second stripping and retaining slot (18) substantially parallel to the first and offset relative to the direction of the slots; a push-member (8) designed to receive two electric cables (10) and configured such that each cable should be located transversely opposite a stripping and retaining slot (18), and means (4) for producing a relative displacement between the push-member (8) and the stripping slots (18).

Abstract: Methods for detection of the onset or presence of sporadic basal cell carcinoma in an animal by measuring for elevated levels of extopic expression of Gli1 in the animal's epidermal tissue sample suspected of harboring sporadic basal cell carcinoma.

Abstract: This invention provides an isolated protein comprising an amino acid sequence of a C-terminal Gli 1 truncate, wherein the protein acts as a dominant-negative repressor of neuronal differentiation. This invention provides an isolated protein comprising an amino acid sequence of a C-terminal Gli 2 truncate, wherein the protein acts as a dominant-negative repressor of neuronal differentiation. This invention provides an isolated protein comprising an amino acid sequence of a C-terminal Gli 3 truncate, wherein the protein acts as a dominant-negative repressor of neuronal differentiation. In addition, this invention provides a pharmaceutical composition comprising an amount of the protein truncate or fragment and a pharmaceutically acceptable carrier ordiluent. This invention provides a method of identifying a test composition or agent which modulates Gli 1, Gli 2, or Gli 3 and a method of identifying/screening a cell for protein truncates or fragments of Gli protein family.

Abstract: Piece with a profiled shape having a hollow polygonal section along which an insulation-displacement and retaining slit for at least one wire is made. One face of the polygonal section is extended as a lug and curved toward the connecting piece, leaving a space intended to take a prong of an interconnection comb between the curved lug and the connecting piece. A connecting device comprising the piece, and an insulating casing.

Abstract: The invention concerns a device with a conductive core (10a) and an insulating sheath (10b) comprising a stripping and retaining slot (18). It comprises: a second stripping and retaining slot (18) substantially parallel to the first and offset relative to the direction of the slots; a push-member (8) designed to receive two electric cables (10) and configured such that each cable should be located transversely opposite a stripping and retaining slot (18), and means (4) for producing a relative displacement between the push-member (8) and the stripping slots (18).