Abstract: A method for predicting an immunogenic and/or therapeutic response to adalimumab 5 from a sample extracted from a rheumatoid arthritis patient by testing the sample for the presence of biomarkers, the biomarkers being autoantibodies to antigens comprising SSB, TROVE2 and ZHX2.

Abstract: A method for determining the health status of an elderly individual by testing the sample extracted from the individual for the presence of biomarkers, the bio markers being autoantibodies to antigens comprising MAPK13, CD96, FKBP3, PPM1A, PHLDA1, GLRX3, FEN1 and AURKA, wherein the antigens may further comprise one or more of UBE2I, AAK1, YARS, ASPSCR1, CASP10, FHOD2, TCL1A and MAP4, wherein PHLDA1 and CD96 correspond to healthy, AURKA, FEN1, CASP10 and AAK1 correspond to intermediate health, and UBE2I, YARS, ASPSCR1, FHOD2, TCL1A, MAP4, MAPK13, FKBP3, PPM1A and GLRX3 correspond to unhealthy.

Abstract: A method for diagnosing Non-Small Cell Lung Cancer (NSCLC) from a sample extracted from a subject by testing the sample for the presence of biomarkers, the biomarkers being autoantibodies against XAGE1D, LRRFIP2 and GAGE2C. Also claimed are a method of manufacturing a kit, and compositions comprising a panel of said antigens or exosomal autoantibodies.

Abstract: The present disclosure relates to a method for detecting a biomarker selected from the group consisting of Nucleotide binding protein 2 (NUBP2), Testis specific protein Y-linked 3 (TSPY3), XAGE-4 protein (XAGE4), Testis specific protein Y-linked 2 (TSPY2), Replication protein A2 (RPA2), Pyrroline-5-carboxylate reductase 1 (PYCR1), Thymidine kinase 1 (TK1), High mobility group nucleosome binding domain 5 (HMGN5/NSBP1), Rhophilin associated protein 1 (ROPN1, Ropporin), RNA binding motif protein 46 (RBM46), Proteasome (prosome, macropain) activator subunit 3 (PSME3), Keratin 19 (KRT19), Transgelin (TAGLN), Peroxiredoxin (PRDX1), S100 Calcium binding protein A9 (S100A9), and Inosine monophosphate dehydrogenase 1 (IMPDH1), in a sample. The present disclosure provides for the use of biomarker for the detection of oral cancer in a sample. The detection of the biomarker helps in early diagnosis of oral cancer.