Patents by Inventor Aristos A. Aristidou

Aristos A. Aristidou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090226989
    Abstract: Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
    Type: Application
    Filed: May 30, 2006
    Publication date: September 10, 2009
    Inventors: Pirkko Suominen, Aristos Aristidou, Merja Penttila, Marja Ilmen, Laura Ruohonen, Kari Koivuranta, Kevin Roberg-Perez
  • Publication number: 20090226990
    Abstract: Methods for producing a biofuel are provided. Also provided are biocatalysts that convert a feedstock to a biofuel.
    Type: Application
    Filed: October 31, 2008
    Publication date: September 10, 2009
    Applicant: GEVO, Inc.
    Inventors: Andrew C. Hawkins, David A. Glassner, Thomas Buelter, James Wade, Peter Meinhold, Matthew W. Peters, Patrick R. Gruber, William A. Evanko, Aristos A. Aristidou
  • Publication number: 20090226991
    Abstract: There is disclosed a method of producing isobutanol. In an embodiment, the method includes providing a microorganism transformed with an isobutanol producing pathway containing at least one exogenous gene. The microorganism is selected to produce isobutanol from a carbon source at a yield of at least 10 percent theoretical. The method includes cultivating the microorganism in a culture medium containing a feedstock providing the carbon source, until isobutanol is produced. The method includes recovering the isobutanol. In one embodiment, the microorganism is a yeast with a Crabtree-negative phenotype. In another embodiment, the microorganism is a yeast microorganism with a Crabtree-positive phenotype. There is disclosed a microorganism for producing isobutanol. In an embodiment, the microorganism includes an isobutanol producing pathway containing at least one exogenous gene, and is selected to produce a recoverable quantity of isobutanol from a carbon source at a yield of at least 10 percent theoretical.
    Type: Application
    Filed: December 23, 2008
    Publication date: September 10, 2009
    Applicant: GEVO, INC.
    Inventors: Reid M. Renny FELDMAN, Uvini GUNAWARDENA, Jun URANO, Peter MEINHOLD, Aristos A. ARISTIDOU, Catherine Asleson DUNDON, Christopher SMITH
  • Publication number: 20090215137
    Abstract: Methods for producing a biofuel precursor are provided. Also provided are biocatalysts that convert a feedstock to a biofuel precursor.
    Type: Application
    Filed: October 31, 2008
    Publication date: August 27, 2009
    Applicant: GEVO, INC.
    Inventors: Andrew C. Hawkins, David A. Glassner, Thomas Buelter, James Wade, Peter Meinhold, Matthew W. Peters, Patrick R. Gruber, William A. Evanko, Aristos A. Aristidou
  • Publication number: 20090171129
    Abstract: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.
    Type: Application
    Filed: December 23, 2008
    Publication date: July 2, 2009
    Applicant: Gevo, Inc.
    Inventors: William A. Evanko, Aharon M. Eyal, David A. Glassner, Fudu Miao, Aristos A. Aristidou, Kent Evans, Patrick R. Gruber, Andrew C. Hawkins
  • Publication number: 20090053782
    Abstract: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyueromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
    Type: Application
    Filed: March 13, 2007
    Publication date: February 26, 2009
    Inventors: Catherine Asleson Dundon, Pirkko Suominen, Aristos Aristidou, Brian J. Rush, Kari Koivuranta, Benjamin Matthew Hause, Thomas William McMullin, Kevin Roberg-Perez
  • Publication number: 20080038779
    Abstract: The invention relates to the methods of manufacturing five-carbon sugars and sugar alcohols as well as other compounds derived from pentose-phosphate pathway from readily available substrates such a hexoses using metabolically engineered microbial hosts.
    Type: Application
    Filed: May 22, 2007
    Publication date: February 14, 2008
    Inventors: Andrei Miasnikov, Heikki Ojamo, Mira Povelainen, Hakan Gros, Mervi Toivari, Peter Richard, Laura Ruohonen, Kari Koivuranta, John Londesborough, Aristos Aristidou, Merja Penttila, Claire Plazanet-Menut, Josef Deutscher
  • Publication number: 20070148748
    Abstract: Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.
    Type: Application
    Filed: February 14, 2007
    Publication date: June 28, 2007
    Inventors: Pim Hoek, Aristos Aristidou, Brian Rush
  • Patent number: 7232664
    Abstract: Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: June 19, 2007
    Assignee: NatureWorks LLC
    Inventors: Pim Van Hoek, Aristos Aristidou, Brian Rush
  • Patent number: 7226761
    Abstract: The invention relates to the methods of manufacturing five-carbon sugars and sugar alcohols as well as other compounds derived from pentose-phosphate pathway from readily available substrates such a hexoses using metabolically engineered microbial hosts.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: June 5, 2007
    Assignee: Danisco Sweeteners Oy
    Inventors: Andrei Miasnikov, Heikki Ojamo, Mira Povelainen, Hakan Gros, Mervi Toivari, Peter Richard, Laura Ruohonen, Kari Koivuranta, John Londesborough, Aristos Aristidou, Merja Penttila, Claire Plazanet-Menut, Josef Deutscher
  • Publication number: 20060234364
    Abstract: Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications', include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
    Type: Application
    Filed: May 3, 2004
    Publication date: October 19, 2006
    Inventors: Vineet Rajgarhia, Kari Koivuranta, Merja Penttilä, Marja Ilmen, Pirkko Suominen, Aristos Aristidou, Christopher Miller, Stacey Olson, Laura Ruohonen
  • Patent number: 7091014
    Abstract: The present invention relates to genetic engineering of production microorganisms used in biotechnology to improve their properties so that they produce useful products more efficiently. The microorganisms express at least one enzyme that causes the functional coupling of the oxidation and reduction of substrates by two pyridine nucleotide-linked dehydrogenase reactions with different specificities for the NAD/NADH and NADP/NADPH coenzyme couples and so facilitates the transfer of electrons between the two coenzyme couples through the said substrates. In particular the invention relates to increasing the yields of products such as ethanol or amino acids from carbon and nitrogen sources such as biomass comprising hexoes, pentoses or their polymers.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: August 15, 2006
    Assignee: Valtion Teknillinen Tutkimuskeskus
    Inventors: Aristos Aristidou, John Londesborough, Merja Penttilä, Peter Richard, Laura Ruohonen, Hans Söderlund, Anita Teleman, Mervi Toivari
  • Publication number: 20040043444
    Abstract: Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.
    Type: Application
    Filed: May 30, 2003
    Publication date: March 4, 2004
    Inventors: Pim Van Hoek, Aristos Aristidou, Brian Rush
  • Publication number: 20030068791
    Abstract: The invention relates to the methods of manufacturing five-carbon sugars and sugar alcohols as well as other compounds derived from pentose-phosphate pathway from readily available substrates such a hexoses using metabolically engineered microbial hosts.
    Type: Application
    Filed: July 20, 2001
    Publication date: April 10, 2003
    Applicant: Xyrofin Oy
    Inventors: Andrei Miasnikov, Heikki Ojamo, Mira Povelainen, Hakan Gros, Mervi Toivari, Peter Richard, Laura Ruohonen, Kari Koivuranta, John Londesborough, Aristos Aristidou, Merja Penttila, Claire Plazanet-Menut, Josef Deutscher