Patents by Inventor Arja Karjalainen
Arja Karjalainen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11046713Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.Type: GrantFiled: February 24, 2020Date of Patent: June 29, 2021Assignee: ORION CORPORATIONInventors: Gerd Wohlfahrt, Olli Törmäkangas, Harri Salo, Iisa Höglund, Arja Karjalainen, Pia Koivikko, Patrik Holm, Sirpa Rasku, Anniina Vesalainen
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Publication number: 20200299307Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: February 24, 2020Publication date: September 24, 2020Inventors: Gerd WOHLFAHRT, Olli TÖRMÄKANGAS, Harri SALO, Iisa HÖGLUND, Arja KARJALAINEN, Pia KOIVIKKO, Patrik HOLM, Sirpa RASKU, Anniina VESALAINEN
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Patent number: 10711013Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.Type: GrantFiled: September 25, 2018Date of Patent: July 14, 2020Assignee: ORION CORPORATIONInventors: Gerd Wohlfahrt, Olli Törmäkangas, Harri Salo, Iisa Höglund, Arja Karjalainen, Pia Koivikko, Patrik Holm, Sirpa Rasku, Anniina Vesalainen
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Publication number: 20190100536Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: September 25, 2018Publication date: April 4, 2019Inventors: Gerd WOHLFAHRT, Olli TÖRMÄKANGAS, Harri SALO, Iisa HÖGLUND, Arja KARJALAINEN, Pia KOIVIKKO, Patrik HOLM, Sirpa RASKU, Anniina VESALAINEN
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Patent number: 10118933Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.Type: GrantFiled: April 13, 2017Date of Patent: November 6, 2018Assignee: ORION CORPORATIONInventors: Gerd Wohlfahrt, Olli Törmäkangas, Harri Salo, Iisa Höglund, Arja Karjalainen, Pia Koivikko, Patrik Holm, Sirpa Rasku, Anniina Vesalainen
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Patent number: 9890139Abstract: Compounds of formula (I) wherein R1 to R8, A, B, Z1, and Z2 are as defined in the claims and pharmaceutically acceptable salts and esters thereof are disclosed. The compounds of formula (I) possess utility as androgen receptor antagonists (inhibitors) and/or cytochrome P450 monooxygenase 17?-hydroxylase/17,20-lyase (CYP17) inhibitors. The compounds are useful as medicaments in the treatment of cancer, particularly prostate cancer, and other androgen dependent conditions and diseases where androgen antagonism is desired.Type: GrantFiled: June 10, 2014Date of Patent: February 13, 2018Assignee: ORION CORPORATIONInventors: Gerd Wohlfahrt, Petteri Rummakko, Arja Karjalainen, Mikko Passiniemi, Pekka Pietikäinen, Anssi Haikarainen, Emilia Väisänen, Eija Tiainen
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Publication number: 20170260206Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: April 13, 2017Publication date: September 14, 2017Inventors: Gerd WOHLFAHRT, Olli TÖRMÄKANGAS, Harri SALO, lisa HÖGLUND, Arja KARJALAINEN, Pia KOIVIKKO, Patrik HOLM, Sirpa RASKU, Anniina VESALAINEN
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Patent number: 9657003Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.Type: GrantFiled: January 16, 2015Date of Patent: May 23, 2017Assignee: ORION CORPORATIONInventors: Gerd Wohlfahrt, Olli Törmäkangas, Harri Salo, Iisa Höglund, Arja Karjalainen, Pia Koivikko, Patrik Holm, Sirpa Rasku, Anniina Vesalainen
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Publication number: 20160130254Abstract: Compounds of formula (I) wherein R1 to R8, A, B, Z1, and Z2 are as defined in the claims and pharmaceutically acceptable salts and esters thereof are disclosed. The compounds of formula (I) possess utility as androgen receptor antagonists (inhibitors) and/or cytochrome P450 monooxygenase 17?-hydroxylase/17,20-lyase (CYP17) inhibitors. The compounds are useful as medicaments in the treatment of cancer, particularly prostate cancer, and other androgen dependent conditions and diseases where androgen antagonism is desired.Type: ApplicationFiled: June 10, 2014Publication date: May 12, 2016Inventors: Gerd WOHLFAHRT, Petteri RUMMAKKO, Arja KARJALAINEN, Mikko PASSINIEMI, Pekka PIETIKÄINEN, Anssi HAIKARAINEN, Emilia VÄISÄNEN, Eija TIAINEN
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Publication number: 20150203479Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: January 16, 2015Publication date: July 23, 2015Inventors: Gerd WOHLFAHRT, Olli TÖRMÄKANGAS, Harri SALO, Iisa HÖGLUND, Arja KARJALAINEN, Pia KNUUTTILA, Patrik HOLM, Sirpa RASKU, Anniina VESALAINEN
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Patent number: 8975254Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.Type: GrantFiled: October 27, 2010Date of Patent: March 10, 2015Assignee: Orion CorporationInventors: Gerd Wohlfahrt, Olli Törmäkangas, Harri Salo, Iisa Höglund, Arja Karjalainen, Pia Knuuttila, Patrik Holm, Sirpa Rasku, Anniina Vesalainen
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Patent number: 8921378Abstract: Compounds of formula (I) or (II) wherein Rx, Rz, R9, R10, R14, R14?, R15, R15?, A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.Type: GrantFiled: April 20, 2012Date of Patent: December 30, 2014Assignee: Orion CorporationInventors: Olli Törmäkangas, Gerd Wohlfahrt, Harri Salo, Rathna Durga Ramasubramanian, Pranab Kumar Patra, Arputharaj Ebenezer Martin, Terhi Heikkinen, Anniina Vesalainen, Anu Moilanen, Arja Karjalainen
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Publication number: 20140094474Abstract: Compounds of formula (I) or (II) wherein Rx, Rz, R9, R10, R14, R14?, R15, R15?, A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.Type: ApplicationFiled: April 20, 2012Publication date: April 3, 2014Applicant: ORION CORPORATIONInventors: Olli Törmakängas, Gerd Wohlfahrt, Harri Salo, Rathna Durga Ramasurbamanian, Pranab Kumar Patra, Arputharaj Ebenezer Martin, Terhi Heikkinen, Anniina Vesalainen, Anu Moilanen, Arja Karjalainen
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Patent number: 8501814Abstract: A compound of formula (I), an isomer, metabolite, or a pharmaceutically acceptable salt or ester thereof is disclosed. Compounds of the invention possess utility as a tissue-selective androgen receptor modulators (SARM) and are useful in hormonal therapy, e.g. in the treatment or prevention of hypogonadism, muscle wasting, osteoporosis, benign prostate hyperplasia, obesity associated with a metabolic syndrome, male and female sexual dysfunction and reduced libido, and androgen decline in aging male or female.Type: GrantFiled: March 2, 2007Date of Patent: August 6, 2013Assignee: Orion CorporationInventors: Jari Ratilainen, Olli Törmäkangas, Arja Karjalainen, Paavo Huhtala
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Publication number: 20120225867Abstract: The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: October 27, 2010Publication date: September 6, 2012Inventors: Gerd Wohlfahrt, Olli Törmäkangas, Harri Salo, lisa Höglund, Arja Karjalainen, Pia Knuuttila, Patrik Holm, Sirpa Rasku, Anniina Vesalainen
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Publication number: 20090054525Abstract: A compound of formula (I), an isomer, metabolite, or a pharmaceutically acceptable salt or ester thereof is disclosed. Compounds of the invention possess utility as a tissue-selective androgen receptor modulators (SARM) and are useful in hormonal therapy, e.g. in the treatment or prevention of hypogonadism, muscle wasting, osteoporosis, benign prostate hyperplasia, obesity associated with a metabolic syndrome, male and female sexual dysfunction and reduced libido, and androgen decline in aging male or female.Type: ApplicationFiled: March 2, 2007Publication date: February 26, 2009Inventors: Jari Ratilainen, Olli Tormakangas, Arja Karjalainen, Paavo Huhtala
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Patent number: 7390923Abstract: Compounds of formula (I) wherein R1 to R4, X and A are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are useful in hormonal therapy, e.g., in the treatment or prevention of male hypogonadism and age-related conditions such as andropause.Type: GrantFiled: June 24, 2004Date of Patent: June 24, 2008Assignee: Orion CorporationInventors: Jari Ratilainen, Anu Moilanen, Olli Törmäkangas, Arja Karjalainen, Paavo Huhtala, Gerd Wohlfahrt, Pekka Kallio
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Patent number: 6479530Abstract: Imidazole derivatives of formula I wherein n is 0 or 1, R1 is hydrogen or C1-C4-alkyl, R2 is hydrogen or R2 and R3 together form a double bond, R3 is hydrogen or C1-C4-alkyl or R2 and R3 together form a double bond, R4 is hydrogen, C1-C4-alkyl, hydroxy or C1-C4-alkoxy, R5 is hydrogen or C1-C4-alkyl or R4 and R5 together with the carbon atom to which they are attached form a carbonyl group, R6, R7 and R8 are each the same or different and are independently hydrogen, C1-C4-alkyl or C2-C4-alkenyl, C3-C7-cycloalkyl, hydroxy, C1-C4-alkoxy, C1-C4-hydroxyalkyl, thiol, C1-4-alkylthio, C1-4-alkylthiol, halogen, trifluoromethyl, nitro or optionally substituted amino, X is —CHR9—(CHR10)m—, m is 0 or 1, and R9 and R10 are each the same or different and are independently hydrogen or C1-C4-alkyl; or a pharmaceutically acceptable ester or salt thereof, their preparation, use and pharmaceutical compositions comprising them are described.Type: GrantFiled: July 16, 2001Date of Patent: November 12, 2002Assignee: Orion CorporationInventors: Arto Karjalainen, Paavo Huhtala, Juha-Matti Savola, Siegfried Wurster, Maire Eloranta, Maarit Hillilä, Raimo Saxlund, Victor Cockcroft, Arja Karjalainen
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Patent number: 6388090Abstract: An imidazole derivative of formula (I) or a pharmaceutically acceptable salt or derivative thereof. The compounds of formula I exhibit affinity for alpha2 adrenoceptors.Type: GrantFiled: January 12, 2001Date of Patent: May 14, 2002Assignee: Orion CorporationInventors: Paavo Huhtala, Arto Karjalainen, Antti Haapalinna, Jyrki Lehtimäki, Arja Karjalainen, Raimo Virtanen
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Patent number: 6362211Abstract: A compound of formula I wherein R1 to R3, —A—, m and t are as defined in claim 1, or a pharmaceutically acceptable salt or ester thereof, useful as an alpha2 adrenergic agent.Type: GrantFiled: May 7, 2001Date of Patent: March 26, 2002Assignee: Orion CorporationInventors: Jari Ratilainen, Paavo Huhtala, Arto Karjalainen, Arja Karjalainen, Antti Haapalinna, Raimo Virtanen, Jyrki Lehtimäki