Abstract: Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome.

Abstract: Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome.

Abstract: Methods and systems are described for implementing a photodynamic therapy. An example method may comprise determining, during photodynamic therapy and using a plurality of optical probes spatially distributed within a patient, data indicative of one or more of a photodynamic therapy dosage, a fluence rate of a photodynamic therapy treatment light, or a reactive oxygen species concentration associated with corresponding locations of the plurality of optical probes. The example method may comprise changing, based on the data, one or more treatment parameters associated with providing a photodynamic therapy.

Abstract: The present disclosure provides devices and methods for improved hemodynamic monitoring, including devices for characterizing hemodynamic activity within a tissue or region of interest.

Abstract: The present disclosure provides devices and methods for improved hemodynamic monitoring, including techniques for reducing signals related to hemodynamic activity outside the tissue or region of interest.

Abstract: Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome.

Abstract: Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome.

Abstract: The present disclosure provides devices and methods for improved hemodynamic monitoring, including devices for characterizing hemodynamic activity within a tissue or region of interest.

Abstract: The present disclosure provides devices and methods for improved hemodynamic monitoring, including techniques for reducing signals related to hemodynamic activity outside the tissue or region of interest.

Abstract: A method for coregistration of multi-modal images obtained in different geometries includes acquiring multi-modal image data, wherein the multi-model image data includes image data of a first modality and image data of a second modality, wherein the image data of the respective modalities have different geometries, defining a volume of interest in the multi-modal image data, segmenting the image data of the first modality and incorporating segmentation data of the first modality into a reconstruction of the second modality, and applying a registration of the second modality image data to the first modality image data according to a similarity measure through the volume of interest, wherein an output of the registration comprises superimposed multi-modal image data.

Abstract: Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome.

Abstract: An embodiment of the invention includes a device, system and method for determining the characteristics of deep tissue. The novel method includes measuring blood flow rate and oxygenation characteristics of the tissue, and determining oxygen metabolism of the tissue as a function of the measure blood flow rate and measure oxygenation. The blood flow rate characteristics are measured as a function of light fluctuations caused by the tissue, while the oxygenation characteristics are measured as a function of transmission of light through the tissue with respect to the wavelength of light. The tissue may be layered tissue, for example, a portion of a brain. The tissue characteristics may be measured during times of varying levels of exercise intensity.

Abstract: Disclosed are copolymers of carbon nanotubes, as well as processes and applications of carbon nanotube dispersions. Carbon nanotube emulsions and related technology are also disclosed. The controlled deposition of carbon nanotubes on substrates is also provided. Methods of purifying single-walled carbon nanotubes are also provided. Devices made according to the disclosed methods are further described herein.

Abstract: A method for coregistration of multi-modal images obtained in different geometries includes acquiring multi-modal image data, wherein the multi-model image data includes image data of a first modality and image data of a second modality, wherein the image data of the respective modalities have different geometries, defining a volume of interest in the multi-modal image data, segmenting the image data of the first modality and incorporating segmentation data of the first modality into a reconstruction of the second modality, and applying a registration of the second modality image data to the first modality image data according to a similarity measure through the volume of interest, wherein an output of the registration comprises superimposed multi-modal image data.

Abstract: A method for joint analysis of non-concurrent magnetic resonance (MR) and diffuse optical tomography (DOT) images of the breast includes providing a digitized MR breast image volume comprising a plurality of intensities corresponding to a 3-dimensional (3D) grid of voxels, providing a digitized DOT breast dataset comprising a plurality of physiological values corresponding to a finite set of points, segmenting the breast MR image volume to separate tumorous tissue from non-tumorous tissue, registering a DOT breast dataset and the MR image volume and fusing said registered DOT and MR datasets, wherein said fused dataset is adapted for analysis.

Abstract: Extravasation of a fluid applied to a patient is determined by monitoring light transmitted through the tissue of the patient in proximity to a site at which the fluid is being injected. Light is radiated from a plurality of light sources in an encoded manner into the body part at the site at which the fluid is injected and the light that is reflected, scattered, diffused or otherwise emitted from the body part is detected individually by a plurality of light detectors. Signals representative of the detected light are developed and, prior to injection of the fluid, references are developed against which measurements made during injection of the fluid are compared. New light signals having an improved signal-to-noise ratio are developed from the comparisons of the detected light signals with the associated reference signals.

Abstract: The systems comprise source means for illuminating the fluorophores with diffuse photon density waves of a first specified wavelength, whereby the fluorophores will fluoresce re-radiated diffuse photon density waves of a second wavelength after being illuminated with the diffuse photon density waves of the first specified wavelength; detection means for detecting the re-radiated diffuse photon density waves of the second wavelength, wherein there is a phase shift between the diffuse photon density waves of the first wavelength and the diffuse photon density waves of the second wavelength; and processing means interfaced with the detection means for processing data corresponding to the phase shift and the amplitude of the re-radiated waves to determine concentration and lifetime of the fluorophores as a function of spatial position of the fluorophores in the turbid medium.

Abstract: Method and system for imaging media having spatially varying dynamic properties or spatially varying optical properties. The method and system utilizes a diffuse correlation wave which is a function of the properties of the medium. The correlation is constructed from photons which create a speckle pattern which falls on a detector at a known position with respect to the source of the photons after the photons have interacted with the media.

Abstract: Imaging tumors using diffuse light. An imaging system includes a source of diffuse light for generating oscillatory diffuse photon density waves to illuminate an object, a detector for detecting diffuse photon density waves interacting with the object, and a computer interfaced with the detector for processing data corresponding to the photon density waves detected to determine at least a position of the object. In one embodiment, the turbid medium and the object have associated therewith at least one diffusion coefficient and the diffuse photon density waves which illuminate the object refract around the object as a result of their interaction with it, thereby producing a distorted wavefront that allows the computer to construct an image of the object. In another embodiment, a fluorescent object produces re-radiated diffuse photon density waves which allow the object to be imaged.