Patents by Inventor Arlene E. McKeown

Arlene E. McKeown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Niraparib Compositions
    Publication number: 20230416223
    Abstract: The present invention relates to compositions comprising the compound niraparib, in particular certain solid forms of niraparib.
    Type: Application
    Filed: May 1, 2023
    Publication date: December 28, 2023
    Inventors: George Wu, John Chaber, Arlene E. McKeown, Jennifer R. Foley
  • Niraparib compositions
    Patent number: 11673877
    Abstract: The present invention relates to compositions comprising the compound niraparib, in particular certain solid forms of niraparib.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: June 13, 2023
    Assignees: Tesaro, Inc., Merck Sharp & Dohme Corp.
    Inventors: George Wu, John Chaber, Arlene E. McKeown, Jennifer R. Foley
  • Niraparib Compositions
    Publication number: 20210403448
    Abstract: The present invention relates to compositions comprising the compound niraparib, in particular certain solid forms of niraparib.
    Type: Application
    Filed: June 4, 2021
    Publication date: December 30, 2021
    Inventors: George Wu, John Chaber, Arlene E. McKeown, Jennifer R. Foley
  • Niraparib compositions
    Patent number: 11091459
    Abstract: The present invention relates to compositions comprising the compound niraparib, in particular certain solid forms of niraparib.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: August 17, 2021
    Assignees: Tesaro, Inc., Merck Sharp & Dohme Corp.
    Inventors: George Wu, John Chaber, Arlene E. McKeown, Jennifer R. Foley
  • Crystalline forms of dihydropyrazolopyrimidinone
    Patent number: 8198281
    Abstract: The present invention relates to the crystalline forms of 2-allyl-1-[6-(I-hydroxy-1 methylethyl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one or a salt thereof, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.
    Type: Grant
    Filed: April 22, 2008
    Date of Patent: June 12, 2012
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Masashi Kawasaki, Hiroo Mizuno, Toshihiro Sakamoto, Kimimasa Suzuki, Arlene E. McKeown
  • PHARMACEUTICAL COMPOSITIONS OF HDAC INHIBITORS AND CHELATABLE METAL COMPOUNDS, AND METAL-HDAC INHIBITOR CHELATE COMPLEXES
    Publication number: 20120142770
    Abstract: The present invention provides pharmaceutical compositions of an HDAC inhibitor and a chelatable metal compound. In one embodiment, the invention provides a method of treating cancer and alleviating the side effects of the HDAC inhibitor by administering the pharmaceutical composition. In another embodiment, the present invention also provides pharmaceutical compositions of metal HDAC inhibitor chelate complexes. In another embodiment, the invention provides methods of treating cancer by administering the pharmaceutical compositions. The invention provides crystalline compositions of metal HDAC inhibitor chelate complexes and methods of producing same.
    Type: Application
    Filed: November 16, 2011
    Publication date: June 7, 2012
    Applicant: Merck Sharp & Dohme Corp
    Inventors: Arlene E. McKeown, Thomas A. Miller
  • CRYSTALLINE FORMS OF DIHYDROPYRAZOLOPYRIMIDINONE
    Publication number: 20100124544
    Abstract: The present invention relates to the crystalline forms of 2-allyl-1-[6-(I-hydroxy-1 methylethyl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one or a salt thereof, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.
    Type: Application
    Filed: April 22, 2008
    Publication date: May 20, 2010
    Inventors: Masashi Kawasaki, Hiroo Mizuno, Toshihiro Sakamoto, Kimimasa Suzuki, Arlene E. Mckeown
  • Novel Crystalline Forms of Antidiabetic Compounds
    Publication number: 20090264473
    Abstract: A novel crystalline anhydrate of the free acid and a crystalline anhydrous besylate salt of a selective PPAR gamma partial agonist which has a fused bicyclic aromatic group attached to an oxypropanoic acid moiety are stable and non-hygroscopic. The compounds are suitable for preparing pharmaceutical formulations for the treatment of type 2 diabetes, hyperglycemia, obesity, and dyslipidemia.
    Type: Application
    Filed: March 2, 2007
    Publication date: October 22, 2009
    Inventors: Zhiguo Jake Song, Arlene E McKeown
  • Pharmaceutical compositions of HDAC inhibitors and chelatable metal compounds, and metal-HDAC inhibitors chelate complexes
    Publication number: 20090239946
    Abstract: The present invention provides pharmaceutical compositions of an HDAC inhibitor and a chelatable metal compound. In one embodiment, the invention provides a method of treating cancer and alleviating the side effects of the HDAC inhibitor by administering the pharmaceutical composition. In another embodiment, the present invention also provides pharmaceutical compositions of metal HDAC inhibitor chelate complexes. In another embodiment, the invention provides methods of treating cancer by administering the pharmaceutical compositions. The invention provides crystalline compositions of metal HDAC inhibitor chelate complexes and methods of producing same.
    Type: Application
    Filed: September 24, 2007
    Publication date: September 24, 2009
    Inventors: Arlene E. McKeown, Thomas A. Miller
  • Crystalline forms of an HIV integrase inhibitor
    Publication number: 20080280945
    Abstract: Crystalline forms of a hexahydro-diazocinonaphthyridine trione compound are disclosed. The compound and its crystalline forms thereof are HIV integrase inhibitors useful for the prophylaxis or treatment of HIV infection or for the prophylaxis, treatment or delay in the onset or progression of AIDS.
    Type: Application
    Filed: May 8, 2008
    Publication date: November 13, 2008
    Inventors: Sachin Lohani, Zhihui Peng, Arlene E. McKeown