Patents by Inventor Armin Roessler

Armin Roessler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
    Patent number: 8703948
    Abstract: The present invention is directed to salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by NOP, for example depression, anxiety, alcohol abuse, etc. The present invention is further directed to process(es) for the preparation of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one and its corresponding salts.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: April 22, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Steven J. Mehrman, Armin Roessler, Roger Faessler, Frank J. Villani, Jean Francois Alexandre Lucas
  • Lysine salts of 4-((phenoxyalkyl)thio)-phenoxyacetic acid derivatives
    Patent number: 8669288
    Abstract: The present invention is directed to a novel lysine salts, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by PPAR delta. The present invention is further directed to a novel process for the preparation of said lysine salts.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: March 11, 2014
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ahmed F. Abdel-Magid, Steven J. Mehrman, Armin Roessler
  • Synthesis of quaternary salt compounds
    Patent number: 8168829
    Abstract: The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: May 1, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: David C. Palmer, Sergio Casco-Cancian, Tong Xiao, Kirk L. Sorgi, Armin Roessler, Anita Vladislavic, Roger Faessler
  • NOVEL LYSINE SALTS OF 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACID DERIVATIVES
    Publication number: 20110105616
    Abstract: The present invention is directed to a novel lysine salts, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by PPAR delta. The present invention is further directed to a novel process for the preparation of said lysine salts.
    Type: Application
    Filed: March 18, 2010
    Publication date: May 5, 2011
    Inventors: AHMED F. ABDEL-MAGID, STEVEN J. MEHRMAN, ARMIN ROESSLER
  • SYNTHESIS OF QUATERNARY SALT COMPOUNDS
    Publication number: 20090112004
    Abstract: The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.
    Type: Application
    Filed: October 22, 2008
    Publication date: April 30, 2009
    Inventors: David C. Palmer, Sergio Casco-Cancian, Tong Xiao, Kirl L. Sorgi, Armin Roessler, Anita Vladislavic, Roger Faessler
  • Process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid
    Patent number: 7470809
    Abstract: The present invention relates to a novel process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid, a compound obtainable from phthalic anhydride. The process comprises the subsequent steps a) through e): a) reacting phthalic anhydride with fluorobenzene or a derivative thereof in appropriate reaction conditions; b) over reducing the product obtained in step a) at the ketone moiety; c) reducing the product obtained in step b) with sodium dihydro-bis(2-methoxyethoxy)aluminate (Red-Al) to the corresponding alcohol; d) chlorinating the alcohol obtained in step c); e) inserting CO into the product obtained in step d) through an appropriate Pd-containing catalytic system. In an alternative embodiment, the step e) is replaced by the steps f1) and f2): f1) reacting the product obtained in step d) with sodium cyanide; f2) hydrolysing the product obtained in step f1).
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: December 30, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michel Joseph Maurice André Guillaume, Yolande Lydia Lang, Armin Roessler, Lars Ulmer, Stefan Marcel Herman Leurs, Dirk De Smaele
  • SALTS OF 3-(3-AMINO-2-(R)-HYDROXY-PROPYL)-1-(4-FLUORO-PHENYL)-8-(8-METHYL-NAPHTHALEN-1-YLMETHYL)-1,3,8-TRIAZA-SPIRO[4.5]DECAN-4-ONE
    Publication number: 20080176882
    Abstract: The present invention is directed to salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by NOP, for example depression, anxiety, alcohol abuse, etc. The present invention is further directed to process(es) for the preparation of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one and its corresponding salts.
    Type: Application
    Filed: November 14, 2007
    Publication date: July 24, 2008
    Inventors: Steven J. MEHRMAN, Armin Roessler, Roger Faessler, Frank J. Villani, Jean Francois Alexandre Lucas Hegyi
  • One-Pot Condensation-Reduction Methods for Preparing Substituted Allylic Alcohols
    Publication number: 20080009628
    Abstract: One-pot condensation-reduction methods for preparing substituted allylic alcohols as well as highly selective extractive methods to separate isomeric alcohols produced in the one-pot condensation-reduction processes are provided for preparing, for example, a quinolone.
    Type: Application
    Filed: June 13, 2007
    Publication date: January 10, 2008
    Inventors: Michael Reuman, Roger Faessler, Armin Roessler, Kirk Sorgi, Xun Li, Jeffrey S. Grimm
  • NOVEL PROCESS FOR THE PRODUCTION OF [2-(4-FLUORO-BENZYL)-PHENYL]-ACETIC ACID
    Publication number: 20070213556
    Abstract: The present invention relates to a novel process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid, a compound obtainable from phthalic anhydride. The process comprises the subsequent steps a) through e): a) reacting phthalic anhydride with fluorobenzene or a derivative thereof in appropriate reaction conditions; b) over reducing the product obtained in step a) at the ketone moiety; c) reducing the product obtained in step b) with sodium dihydro-bis(2-methoxyethoxy)aluminate (Red-Al) to the corresponding alcohol; d) chlorinating the alcohol obtained in step c); e) inserting CO into the product obtained in step d) through an appropriate Pd-containing catalytic system. In an alternative embodiment, the step e) is replaced by the steps f1) and f2): f1) reacting the product obtained in step d) with sodium cyanide; f2) hydrolysing the product obtained in step f1).
    Type: Application
    Filed: August 26, 2005
    Publication date: September 13, 2007
    Inventors: Michel Joseph Guillaume, Yolande Lang, Armin Roessler, Lars Ulmer, Stefan Leurs, Dirk De Smaele
  • Process for preparing peptidyl heterocyclic ketone derivatives
    Patent number: 7205384
    Abstract: The present invention relates to novel processes for the preparation of peptidyl heterocyclic ketones of the general formula (I) wherein all variables are as herein defined. The present invention further relates to novel pharmaceutical salts and processes for their preparation. The peptidyl heterocyclic ketones of formula (I) are potent and selective inhibitors of tryptase, useful for the treatment and prevention of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: April 17, 2007
    Assignee: Ortho-McNeil Pharmaceutical Inc.
    Inventors: Michael Breslav, Bruce Harris, Birdella Kenney, Thomas Maier, Armin Roessler, Frank Villani, Ulrich Weigl, Fan Zhang-Plasket, Hua Zhong
  • Process for preparing peptidyl heterocyclic ketone derivatives
    Publication number: 20050059607
    Abstract: The present invention relates to novel processes for the preparation of peptidyl heterocyclic ketones of the general formula (I) wherein all variables are as herein defined. The present invention further relates to novel pharmaceutical salts and processes for their preparation. The peptidyl heterocyclic ketones of formula (I) are potent and selective inhibitors of tryptase, useful for the treatment and prevention of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.
    Type: Application
    Filed: July 29, 2004
    Publication date: March 17, 2005
    Inventors: Michael Breslav, Bruce Harris, Birdella Kenney, Thomas Maier, Armin Roessler, Frank Villani, Ulrich Weigl, Fan Zhang-Plasket, Hua Zhong
  • Process for preparing [S-(R*,S*)]-&bgr;-[[[1-[1-oxo-3(4-piperidinyl)propyl]-3-piperidinyl]carbonyl]amino]-3-pyridinepropanoic acid and derivatives
    Patent number: 6515130
    Abstract: A process for preparing a compound of formula I wherein R1 and R2 are independently selected from the group consisting of hydrogen, lower alkyl and halogen
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: February 4, 2003
    Inventors: Judith H. Cohen, Michael Justus, Cynthia A. Maryanoff, Armin Rössler, Fridtjof Schröder, Kirk L. Sorgi, Frank J. Villani, Jr., Christian Weh