Patents by Inventor Arne Agerlin Olsen
Arne Agerlin Olsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040175757Abstract: The present invention relates to a method of selecting a protein variant having reduced immunogenicity as compared with the parent protein.Type: ApplicationFiled: December 8, 2003Publication date: September 9, 2004Applicant: Novozymes A/SInventors: Arne Agerlin Olsen, Erwin Lugo Roggen, Steffen Ernst
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Patent number: 6686164Abstract: The present invention relates to a method of selecting a protein variant having reduced immunogenicity as compared with the parent protein.Type: GrantFiled: October 13, 1999Date of Patent: February 3, 2004Assignee: Novozymes A/SInventors: Arne Agerlin Olsen, Erwin Lugo Roggen, Steffen Ernst
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Patent number: 6638526Abstract: A polypeptide-polymer conjugate is prepared having one or more polymers covalently bound to a polypeptide. The polymer has the general formula; EOXPOY wherein EO is ethylene oxide, PO is propylene oxide, x=1−99%, y=1−99%, x+y=100%, and x and y are in a ratio range of 10:90 to 90:10, more preferably 40:60 to 60:40, or in a 50/50 ratio. The polymer, which can be a block polymer, typically has a molecular weight in a range of 100 to 100,000 daltons, and the polypeptide may contain 1 to 100 polymer molecules. Coupling the polypeptide, in particular enzymes, to the polymer reduces respiratory allergenicity of the polypeptide. Industrial compositions such as detergent compositions, personal care compositions, compositions for processing/treating textiles, and food and feed compositions containing the polypeptide-polymer conjugate have reduced respiratory allergenicity.Type: GrantFiled: June 23, 1999Date of Patent: October 28, 2003Assignee: Novozymes A/SInventors: Heinz-Josef Deussen, Arne Agerlin Olsen, Tine Muxoll Fatum, Erwin Ludo Roggen
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Patent number: 6623950Abstract: The present invention relates to polypeptide-polymer conjugates having added and/or removed one or more attachment groups for coupling polymeric molecules on the surface of the polypeptide structure, a method for preparing polypeptide-polymer conjugates of the invention, the use of said conjugates for reducing the immunogenicity and allergenicity and compositions comprising said conjugate.Type: GrantFiled: November 2, 2000Date of Patent: September 23, 2003Assignee: Novozymes A/SInventors: Claus von der Osten, Arne Agerlin Olsen, Erwin Ludo Roggen
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Publication number: 20030118572Abstract: The present invention relates to modified enzymes comprising an enzyme and at least one polyanionic domain, e.g. polyglutamic acid, polyaspartic acid or a polycarboxylic acid, wherein the enzyme comprises or is covalently attached to each said polyanionic domain. The present invention also relates to oral care compositions comprising such modified enzymes and use of the oral care compositions for preventing or treating dental disease, in particular for preventing or removing plaque. The modified enzymes are able to bind to hydroxylapatite in teeth.Type: ApplicationFiled: September 9, 2002Publication date: June 26, 2003Applicant: Novozymes A/SInventors: Heinz Josef Deussen, Claus Crone Fuglsang, Arne Agerlin Olsen
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Publication number: 20030087785Abstract: The present invention relates to polypeptides with reduced immune response including reduced allergenicity having one or more amino acid residues being substituted with other amino acid residues and/or having coupled one or more polymeric molecules in the vicinity of the polypeptides metal binding site, a method for preparing modified polypeptides of the invention, the use of the polypeptide for reducing the immunogenicity and allergenicity and compositions comprising the polypeptide.Type: ApplicationFiled: August 1, 2002Publication date: May 8, 2003Applicant: Novozymes A/SInventors: Arne Agerlin Olsen, Claus von der Osten, Kim Vilbour Andersen, Steffen Ernst, Erwin Ludo Roggen
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Publication number: 20030054534Abstract: An isolated nucleic acid constructs encoding cellulytic enzymes derived from a strain of Bacillus agaradherens, recombinant vectors and host cells comprising such constructs, and methods for obtaining cellulytic enzymes.Type: ApplicationFiled: July 11, 2001Publication date: March 20, 2003Applicant: Novozymes A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisgard-Frantzen, Martin Schulein, Per Linaa Jorgensen, Mads E. Bjoernvad
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Patent number: 6461849Abstract: The present invention relates to polypeptides with reduced immune response including reduced allergenicity having one or more amino acid residues being substituted with other amino acid residues and/or having coupled one or more polymeric molecules in the vicinity of the polypeptides metal binding site, a method for preparing modified polypeptides of the invention, the use of the polypeptide for reducing the immunogenicity and allergenicity and compositions comprising the polypeptide.Type: GrantFiled: October 13, 1999Date of Patent: October 8, 2002Assignee: Novozymes, A/SInventors: Arne Agerlin Olsen, Claus von der Osten, Kim Vilbour Andersen, Steffen Ernst, Erwin Ludo Roggen
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Patent number: 6416756Abstract: Modified enzymes are prepared for use in skin care products by covalently coupling to the enzymes from 4 to 70 polymeric molecules with or without a linker such as a triazine ring. Molecular weight of the polymeric molecules may be from 1 to 35 kDa and of the enzymes from 15 to 100 kDa. The number and weight of polymeric molecules coupled is balanced with the weight and/or surface area of the enzymes. Enzymes include proteases such as subtilisins, lipases and oxidoreductases such as laccases and superoxide dismutase, and polymeric molecules include polysaccharides such as dextran or pullulan and polyalkylene oxides such as polyethylene glycol. The polymeric molecules may be coupled to the enzymes at the N-terminal amino group and/or lysine residues, and preferably at a position more than 5 Å from the active site of the enzymes. A preferred modified enzyme is a protease having from 5 to 13 coupled polymeric molecules.Type: GrantFiled: February 5, 1998Date of Patent: July 9, 2002Assignee: Novozymes A/SInventors: Arne Agerlin Olsen, Annette Prento
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Patent number: 6303752Abstract: The present invention relates to modified polypeptides with reduced respiratory allergenicity having polymeric molecules with a molecular weight from 100 up to 750 Da, coupled covalently to the parent polypeptide having a molecular weight from 5 to 100 kDa. The present invention also relates to industrial compositions comprising modified polypeptide with reduced respiratory allergenicity, skin care products, the use of modified polypeptides for reducing the allergenicity of industrial composition and products and finally a method for reducing the allergenicity of polypeptides.Type: GrantFiled: June 25, 1998Date of Patent: October 16, 2001Assignee: Novozymes A/SInventors: Arne Agerlin Olsen, Tine Muxoll Fatum, Heinz Josef Deussen, Erwin Ludo Roggen
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Patent number: 6280984Abstract: An isolated nucleic acid constructs encoding cellulytic enzymes derived from a strain of Bacillus agaradherens, recombinant vectors and host cells comprising such constructs, and methods for obtaining cellulytic enzymes.Type: GrantFiled: January 7, 1999Date of Patent: August 28, 2001Assignee: Novozymes A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisgård-Frantzen, Martin Schülein, Per Linaa Jorgensen, Mads E. Bjoernvad
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Patent number: 6245901Abstract: The present invention relates to polypeptide-polymer conjugates having added and/or removed one or more attachment groups for coupling polymeric molecules on the surface of the polypeptide structure, a method for preparing polypeptide-polymer conjugates of the invention, the use of said conjugated for reducing the immunogenicity and allergenicity and compositions comprising said conjugate.Type: GrantFiled: February 17, 1998Date of Patent: June 12, 2001Assignee: Novo Nordisk A/SInventors: Claus von der Osten, Arne Agerlin Olsen, Erwin Ludo Roggen
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Patent number: 6201110Abstract: The invention relates to modified polypeptides with reduced respiratory allergenicity comprising a parent polypeptide with a molecular weight from between 10 kDa and 100 kDa conjugated to a polymer with a molecular weight (Mr) in the range of 1 kDa and 60 kDa. The modified polypeptide are produced using a process including the step of conjugating from 1 to 30 polymer molecules with the parent polypeptide. Further the invention relates to compositions comprising said polypeptides and further ingredients normally used in e.g. detergents, including dishwashing detergents and soap bars, household article, agrochemicals, personal care products, cosmetics, toiletries, oral and dermal pharmaceuticals, composition for treating textiles, and compositions used for manufacturing food and feed. Finally the invention is directed to uses of polypeptides with reduced allergenicity or compositions thereof for reducing the allergenicity of products for a vast number of industrial applications.Type: GrantFiled: July 6, 2000Date of Patent: March 13, 2001Assignee: Novo Nordisk A/SInventors: Arne Agerlin Olsen, Lars Bo Hansen, Thomas Christian Beck
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Patent number: 6114509Abstract: The invention relates to modified polypeptides with reduced allergenicity comprising a parent polypeptide with a molecular weight from between 10 kDa and 100 kDa conjugated to a polymer with a molecular weight (M.sub.r) in the range of 1 kDa and 60 kDa. The modified polypeptide are produced using a process including the step of conjugating from 1 to 30 polymer molecules with the parent polypeptide. Further the invention relates to compositions comprising said polypeptides and further ingredients normally used in e.g. detergents, including dishwashing detergents and soap bars, household article, agrochemicals, personal care products, cosmetics, toiletries, oral and dermal pharmaceuticals, composition for treating textiles, and compositions used for manufacturing food and feed. Finally the invention is directed to uses of polypeptides with reduced allergenicity or compositions thereof for reducing the allergenicity of products for a vast number of industrial applications.Type: GrantFiled: September 20, 1999Date of Patent: September 5, 2000Assignee: Novo Nordisk A/SInventors: Arne Agerlin Olsen, Lars Bo Hansen, Thomas Christian Beck
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Patent number: 6106828Abstract: The present invention provides polypeptide conjugates with reduced allergenicity comprising a polymeric carrier molecule having two or more polypeptide molecules coupled thereto. The invention also provides methods for producing the conjugates, compositions comprising the conjugates, and the use of the conjugates in industrial applications, including personal care products and detergent compositions.Type: GrantFiled: July 28, 1998Date of Patent: August 22, 2000Assignee: Novo Nordisk A/SInventors: Henrik Bisgard-Frantzen, Arne Agerlin Olsen, Annette Prento
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Patent number: 6017749Abstract: This invention relates to Alkalophilic Bacillus sp. AC13 microorganisms and cultures, and mutants and variants thereof, and to enzymes obtainable from the microorganism.Type: GrantFiled: February 10, 1998Date of Patent: January 25, 2000Assignee: Novo Nordisk A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisg.ang.rd-Frantzen, Martin Schulein
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Patent number: 5981718Abstract: The invention relates to modified polypeptides with reduced allergenicity comprising a parent polypeptide with a molecular weight from between 10 kDa and 100 kDa conjugated to a polymer with a molecular weight (M.sub.r) in the range of 1 kDa and 60 kDa. The modified polypeptide are produced using a process including the step of conjugating from 1 to 30 polymer molecules with the parent polypeptide. Further the invention relates to compositions comprising said polypeptides and fruther ingredients normally used in e.g. detergents, including dishwashing detergents and soap bars, household article, agrochemicals, personal care products, cosmetics, toiletries, oral and dermal pharmaceuticals, composition for treating textiles, and compositions used for manufacturing food and feed. Finally the invention is directed to uses of polypeptides with reduced allergenicity or compositions thereof for reducing the allergenicity of products for a vast number of industrial applications.Type: GrantFiled: September 10, 1998Date of Patent: November 9, 1999Assignee: Novo Nordisk A/SInventors: Arne Agerlin Olsen, Lars Bo Hansen, Thomas Christian Beck
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Patent number: 5981253Abstract: The present invention relates to novel microorganisms, novel enzymes obtainable herefrom, and to a method of producing the novel enzymes. More specifically, the invention relates to novel enzymes obtainable from strains of the novel alkalophilic species Bacillus sp. AC13. Moreover, the invention relates to a method for producing the enzymes of the invention, and to the use of the enzymes in detergents or in the paper pulp industry.Type: GrantFiled: June 6, 1995Date of Patent: November 9, 1999Assignee: Novo Nordisk A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisg.ang.rd-Frantzen, Martin Schulein
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Patent number: 5945327Abstract: An isolated nucleic acid constructs encoding cellulytic enzymes derived from a strain of Bacillus agaradherens, recombinant vectors and host cells comprising such constructs, and methods for obtaining cellulytic enzymes.Type: GrantFiled: June 6, 1997Date of Patent: August 31, 1999Assignee: Novo Nordisk A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisg.ang.rd-Frantzen, Martin Schulein, Per Linaa Jorgensen, Mads E. Bjoernvad
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Patent number: 5922586Abstract: An isolated nucleic acid constructs encoding cellulytic enzymes derived from a strain of Bacillus agaradherens, recombinant vectors and host cells comprising such constructs, and methods for obtaining cellulytic enzymes.Type: GrantFiled: September 13, 1996Date of Patent: July 13, 1999Assignee: Novo Nordisk A/SInventors: Helle Outtrup, Claus Dambmann, Arne Agerlin Olsen, Henrik Bisg.ang.rd-Frantzen, Martin Schulein, Per Linaa Jorgensen, Mads E. Bjoernvad