Abstract: The present invention relates to compositions devices and methods for treating bone and/or cartilage defects, and a method for manufacturing such a composition or device. In a certain embodiment, the invention provides a device and/or composition for treating bone and/or cartilage defects, having at least one collagen, for example of animal origin, and further containing at least one substance having an osteo-inductive or chondro-inductive activity, at least one differentiation and/or growth factor having osteo-stimulative and/or chondro-stimulative effect, and at least one filling material, in which the composition is in the form of a lyophil.

Abstract: The present invention relates to a method and system to regulate pressure in an object, and is especially suitable for regulating intracranial pressure in people suffering from hydrocephalus. The system includes the measurement of physical parameters other than the pressure to be regulated, especially the present position of the object, such as the inclination.

Abstract: A micro fluidic system comprising at least one tube (1), a membrane (3) and at least one fitting member (4). The fitting member (4) is positioned around the membrane (3) and an end part (2) of the tube(s) (1), thereby fitting the membrane (3) to the end part(s) (2). The fitting member(s) (4) is/are made from a shrinkable material, and it/they is/are fitted tightly around the membrane (3) end part(s) (2). This is obtained by causing the shrinkable material to shrink, e.g. by heating the material, while the fitting member (4) is positioned around the membrane (3) and the end part(s) (2). It is an advantage that the fitting member (4) is made from a shrinkable material because this provides the possibility of fitting the membrane (3) tightly to the end part(s) (2) in an easy and cost effective manner. The micro fluidic system is very suitable for use in a probe, such as a dialysis probe. Also claimed is a method of manufacturing the micro fluidic system.

Abstract: The present invention relates to compositions devices and methods for treating bone and/or cartilage defects, and a method for manufacturing such a composition or device. In a certain embodiment, the invention provides a device and/or composition for treating bone and/or cartilage defects, having at least one collagen, for example of animal origin, and further containing at least one substance having an osteo-inductive or chondro-inductive activity, at least one differentiation and/or growth factor having osteo-stimulative and/or chondro-stimulative effect, and at least one filling material, in which the composition is in the form of a lyophil.

Abstract: The invention relates to a device for preventing incontinence, having a tube-shaped body (3; 129; 203) comprising a first longitudinal guide element (7; 143; 207) in the interior thereof. A hose-like retaining element connects to the tube-shaped body (3), comprising a second longitudinal guide element (13; 113; 213) in the interior thereof. Said second guide element (13; 113; 213) opens in the axial direction into a termination on the side thereof opposite the tube-shaped body (3). The hose-like retaining element is implemented as a reversible stretchable and collapsible metal mesh (23) comprising a polymer coating (25).

Abstract: A tubular implant having an axial end to which is attached a ring of spoons of a material different from that of the implant. In another aspect, the invention provides a method of attaching elements to an axial end of a tubular implant comprising the steps of providing said elements on one end of a support tube having a radius substantially that of the implant in its unexpanded configuration, abutting the implant and elements end-to-end, fixing the elements to the implant, and parting the elements from the support tube. In a third aspect, the invention provides an implant carrying an element of another material, the element and implant having complementary tapered mating surfaces for achieving a taper form-fit of the element onto the implant.

Abstract: The present invention relates to compositions devices and methods for treating bone and/or cartilage defects, and a method for manufacturing such a composition or device. In a certain embodiment, the invention provides a device and/or composition for treating bone and/or cartilage defects, having at least one collagen, for example of animal origin, and further containing at least one substance having an osteo-inductive or chondro-inductive activity, at least one differentiation and/or growth factor having osteo-stimulative and/or chondro-stimulative effect, and at least one filling material, in which the composition is in the form of a lyophil.

Abstract: A tubular implant having an axial end to which is attached a ring of spoons of a material different from that of the implant. In another aspect, the invention provides a method of attaching elements to an axial end of a tubular implant comprising the steps of providing said elements on one end of a support tube having a radius substantially that of the implant in its unexpanded configuration, abutting the implant and elements end-to-end, fixing the elements to the implant; and parting the elements from the support tube. In a third aspect, the invention provides an implant carrying an element of another material, the element and implant having complementary tapered mating surfaces for achieving a taper form fit of the element onto the implant.

Abstract: The present invention relates to a method and system to regulate pressure in an object, and is especially suitable for regulating intracranial pressure in people suffering from hydrocephalus. The system includes the measurement of physical parameters other than the pressure to be regulated, especially the present position of the object, such as the inclination.

Abstract: The present invention relates to compositions devices and methods for treating bone and/or cartilage defects, and a method for manufacturing such a composition or device. In a certain embodiment, the invention provides a device and/or composition for treating bone and/or cartilage defects, having at least one collagen, for example of animal origin, and further containing at least one substance having an osteo-inductive or chondro-inductive activity, at least one differentiation and/or growth factor having osteo-stimulative and/or chondro-stimulative effect, and at least one filling material, in which the composition is in the form of a lyophil.

Abstract: A method for at least partial differentiating stem cells and/or progenitor cells to at least one tissue type includes treating the stem cells and/or the progenitor cells with extracts which include active substances and/or components for differentiating stem cells and/or progenitor cells, and cultivating and differentiating the stem cells and/or the progenitor cells.

Abstract: A micro fluidic system comprising at least one tube (1), a membrane (3) and at least one fitting member (4). The fitting member (4) is positioned around the membrane (3) and an end part (2) of the tube(s) (1), thereby fitting the membrane (3) to the end part(s) (2). The fitting member(s) (4) is/are made from a shrinkable material, and it/they is/are fitted tightly around the membrane (3) end part(s) (2). This is obtained by causing the shrinkable material to shrink, e.g. by heating the material, while the fitting member (4) is positioned around the membrane (3) and the end part(s) (2). It is an advantage that the fitting member (4) is made from a shrinkable material because this provides the possibility of fitting the membrane (3) tightly to the end parts) (2) in an easy and cost effective manner. The micro fluidic system is very suitable for use in a probe, such as a dialysis probe. Also claimed is a method of manufacturing the micro fluidic system.

Abstract: A bioresorbable and mineralized material for filling osseous defects includes a native and/or renatured collagen matrix of congregated collagen chains, in which essentially only a surface of the congregated collagen chains is mineralized. A shaped article for filling osseous defects includes such a material. A method for producing a shaped article for filling osseous defects from a liquid medium, includes the steps of deposition of a mineral substance, preferably from its dissolved ionogenic components, on a collagen matrix, precipitation of the mineralized collagen matrix, separation of the mineralized collagen matrix, transfer of the mineralized collagen matrix to a suspension, transfer of the suspension to a mold defining the shaped article, and freeze-drying of the suspension in the mold.

Abstract: A porous and biocompatible carrier material for treating bone and/or cartilage defects, including a collagen of animal origin that has an active substance complex.

Abstract: Disclosed is a goal gel-type material for filling bone and/or cartilage defects. Said gel-type material comprises at least one gelatinizing component and collagen in at least one liquid dispersing agent. The collagen contains an active substance complex. Preferably, the inventive material is provided with osteoconductive and osteoinductive properties.

Abstract: An implantable body for intersomatic fusion (spinal fusion) is disclosed, made from a bioresorbable, metallic material. Said metallic material preferably contains magnesium or iron as main component. The material is particularly a magnesium alloy or an iron alloy.

Abstract: Disclosed is an application aid (1) for introducing a material (12) used for the treatment of bone defects into a natural bone or a natural bone structure. Said application aid (1) comprises a largely flexible, tubular or sleeve-shaped outer part (2) that is composed of at least two components (3, 4) which can be coaxially moved into each other, a largely flexible, preferably tubular or sleeve-shaped inner part (7), and a discharge port (11) for the material, preferably on the outer part (2). The inventive application aid is preferably embodied such that at least one element which can be moved radially outward at least in part is provided in the interior. Said element represents particularly a balloon.

Abstract: A tubular implant having an axial end to which is attached a ring of spoons of a material different from that of the implant. In another aspect, the invention provides a method of attaching elements to an axial end of a tubular implant comprising the steps of providing said elements on one end of a support tube having a radius substantially that of the implant in its unexpanded configuration, abutting the implant and elements end-to-end, fixing the elements to the implant; and parting the elements from the support tube. In a third aspect, the invention provides an implant carrying an element of another material, the element and implant having complementary tapered mating surfaces for achieving a taper form fit of the element onto the implant.