Patents by Inventor Arne Gehlen

Arne Gehlen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8651284
    Abstract: A hydrophilic semipermeable hollow-fiber membrane for blood treatment, with an integrally asymmetric structure based on a synthetic polymer. The hollow-fiber membrane possesses on its inner surface a separating layer and an adjoining open-pored supporting layer, and has an ultrafiltration rate in albumin solution of 5 to 25 ml/(h·m2·mmHg). The hollow-fiber membrane is free from pore-stabilizing additives and has a maximum sieving coefficient for albumin of 0.005 and a sieving coefficient for cytochrome c that satisfies the equation SCCC?5·10?5·UFRAlb3?0.004·UFRAlb2+1.081·UFRAlb?0.25.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: February 18, 2014
    Assignee: Membrana GmbH
    Inventors: Friedbert Wechs, Arne Gehlen, Bodo von Harten, Richard Kruger, Oliver Schuster
  • Patent number: 8302781
    Abstract: A hydrophilic, semipermeable hollow-fiber membrane for blood treatment, with an integrally asymmetric structure based on a synthetic polymer. The hollow-fiber membrane possesses on its inner surface a porous separating layer and an open-pored supporting layer adjoining the separating layer, and has an ultrafiltration rate in albumin solution of 25 to 60 ml/(h·m2·mmHg). The hollow-fiber membrane is free from pore-stabilizing additives, and has a minimum sieving coefficient for cytochrome c of 0.8 and maximum sieving coefficient for albumin of 0.005.
    Type: Grant
    Filed: February 15, 2005
    Date of Patent: November 6, 2012
    Assignee: Membrana GmbH
    Inventors: Friedbert Wechs, Arne Gehlen, Bodo Von Harten, Richard Kruger, Oliver Schuster
  • Patent number: 7811507
    Abstract: A hydrophilic semipermeable hollow-fibre membrane for blood treatment, with an integrally asymmetric structure based on a synthetic polymer. The hollow-fiber membrane possess on its inner surface a separating layer and an adjoining open-pored supporting layer, and has an ultrafiltration rate in albumin solution of 5 to ?25 ml/(h·m2·mmHg). The hollow fiber membrane is free from pore-stabilizing additives and has a maximum sieving coefficient for albumin of 0.005 and a sieving coefficient of cytochrome c that satisfies the equation SCcc?5·10?5·UFRAlb3?0.004·UFRAlb2+0.1081·UFRAlb?0.25.
    Type: Grant
    Filed: February 15, 2005
    Date of Patent: October 12, 2010
    Assignee: Membrana GmbH
    Inventors: Friedbert Wechs, Arne Gehlen, Bodo Von Harten, Richard Kruger, Oliver Schuster
  • Publication number: 20100089820
    Abstract: A hydrophilic semipermeable hollow-fibre membrane for blood treatment, with an integrally asymmetric structure based on a synthetic polymer. The hollow-fibre membrane possesses on its inner surface a separating layer and an adjoining open-pored supporting layer, and has an ultrafiltration rate in albumin solution of 5 to 25 ml/(h·m2·mmHg). The hollow-fibre membrane is free from pore-stabilising additives and has a maximum sieving coefficient for albumin of 0.005 and a sieving coefficient for cytochrome c that satisfies the equation SCCC?5·10?5·UFRAlb3?0.004·UFRAlb2+1.081·UFRAlb?0.
    Type: Application
    Filed: December 14, 2009
    Publication date: April 15, 2010
    Inventors: Friedbert Wechs, Arne Gehlen, Bodo von Harten, Richard Kruger, Oliver Schuster
  • Publication number: 20080000828
    Abstract: A hydrophilic, semipermeable hollow-fibre membrane for blood treatment, with an integrally asymmetric structure based on a synthetic polymer. The hollow-fibre membrane possesses on its inner surface a porous separating layer and an open-pored supporting layer adjoining the separating layer, and has an ultrafiltration rate in albumin solution of 25 to 60 ml/(h·m2·mmHg). The hollow-fibre membrane is free from pore-stabilising additives, and has a minimum sieving coefficient for cytochrome c of 0.8 and maximum sieving coefficient for albumin of 0.005.
    Type: Application
    Filed: February 15, 2005
    Publication date: January 3, 2008
    Inventors: Friedbert Wechs, Arne Gehlen, Bodo Harten, Richard Kruger, Oliver Schuster
  • Publication number: 20070163949
    Abstract: A hydrophilic semipermeable hollow-fibre membrane for blood treatment, with an integrally asymmetric structure based on a synthetic polymer. The hollow-fibre membrane possesses on its inner surface a separating layer and an adjoining open-pored supporting layer, and has an ultrafiltration rate in albumin solution of 5 to 25 ml/(h·m2·mmHg). The hollow-fibre membrane is free from pore-stabilizing additives and has a maximum sieving coefficient for albumin of 0.005 and a sieving coefficient for cytochrome c that satisfies the equation SCCC?5·10?5·UFRAlb3?0.004·UFRAlb2+1.081·UFRAlb?0.
    Type: Application
    Filed: February 15, 2005
    Publication date: July 19, 2007
    Inventors: Friedbert Wechs, Arne Gehlen, Bodo Harten, Kruger Richard, Schuster Oliver
  • Patent number: 6946527
    Abstract: AGE precursors can be removed from blood, plasma or PBS buffer using a modified polymeric shaped body that can be produced by reaction of diaminoguanidine and/or triaminoguannidine with a staring polymeric shaped body carrying R—X residues, where R is an alkylene group that may or may not be substituted with a hydroxyl group and contains from 1 to 3 carbon atom, and X is a group that is substituted during the reaction by carrying residues Y, on to with diaminoguanidine, or with a starting polymeric shaped body during the reaction which diaminoguanidine and/or triaminoguannidine are added during the reaction.
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: September 20, 2005
    Assignee: Membrana GmbH
    Inventors: Horst Dieter Lemke, Arne Gehlen
  • Publication number: 20050170183
    Abstract: A molded body containing a polyarylether, at the surface of which substituents of formula —(R1—C—R2)—X are bound, where R1?H or an alkyl residue with 1 to 4 C atoms, R2?H or an alkyl residue with 1 to 4 C atoms, and X is a residue of formula NH—(O?C)—CH2-A, where A=F, Cl, Br or I or (CH2)pCHNH2—COOH with p=1 or 2, or a residue of formula NH—(CH2)n—CH2—Y, where Y?H or NH2 and n is an integer between 0 and 6, or a residue of formula O—(CH2)mCH2-Z, where Z=H, OH, COOH, NH2, N-pyrrolidone or N-pyrrolidine and m is an integer between 1 and 5, or a residue of formula NH—NH—(C?NH)—NH2, or a residue of formula NH—(O?C)—CR3?CH2 where R3?H or CH3, or a residue of formula O—(O?C)—(CH2)k-L, where L=COOH or NH2 and k is an integer between 1 and 10, or a residue of formula NH—(O?C)-Ph, where Ph is an unsubstituted or pentahalogenated phenyl residue, or a residue of formula O-G, where G is a glucose residue or glucosamine residue. Also the method for producing such a molded body.
    Type: Application
    Filed: April 16, 2003
    Publication date: August 4, 2005
    Applicant: MEMBRANA GMBH
    Inventor: Arne Gehlen
  • Publication number: 20030171502
    Abstract: AGE precursors can be removed from blood, plasma or PBS buffer using a modified polymeric shaped body that can be produced by reaction of diaminoguanidine and/or triaminoguanidine with a starting polymeric shaped body carrying R—X residues, where R is an alkylene group that may or may not be substituted with a hydroxyl group and contains from 1 to 3 carbon atoms, and X is a group that is substituted during the reaction by diaminoguanidine and/or triaminoguanidine, or with a starting polymeric shaped body carrying residues Y, on to which diaminoguanidine and/or triaminoguanidine are added during the reaction.
    Type: Application
    Filed: January 24, 2003
    Publication date: September 11, 2003
    Inventors: Horst Dieter Lemke, Arne Gehlen