Patents by Inventor Arne Staby

Arne Staby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES AND USE THEREOF
    Publication number: 20220064283
    Abstract: The present invention relates to specific antibodies and use thereof, such as for identifying and/or quantifying liraglutide fibrils and/or semaglutide fibrils.
    Type: Application
    Filed: November 19, 2021
    Publication date: March 3, 2022
    Inventors: Peter Matthew Tessier, Samuel D. Stimple, Arne Staby
  • Antibodies and use thereof
    Patent number: 11208477
    Abstract: The present invention relates to specific antibodies and use thereof, such as for identifying and/or quantifying liraglutide fibrils and/or semaglutide fibrils.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: December 28, 2021
    Assignee: Novo Nordisk A/S
    Inventors: Peter Matthew Tessier, Samuel D. Stimple, Arne Staby
  • SOLUBILITY OF GLP-1 PEPTIDE
    Publication number: 20210261642
    Abstract: The present inventions relates to methods involving incubation of undissolved and/or insoluble GLP-1 peptide in solutions or suspensions comprising one or more organic solvents.
    Type: Application
    Filed: December 19, 2017
    Publication date: August 26, 2021
    Inventors: Florian Dismer, Mattias Hansson, Arne Staby
  • ANTIBODIES AND USE THEREOF
    Publication number: 20200308274
    Abstract: The present invention relates to specific antibodies and use thereof, such as for identifying and/or quantifying liraglutide fibrils and/or semaglutide fibrils.
    Type: Application
    Filed: March 31, 2020
    Publication date: October 1, 2020
    Applicants: Novo Nordisk A/S, Regents of the University of Michigan, Regents of the University of Michigan
    Inventors: Peter Matthew Tessier, Samuel D. Stimple, Arne Staby
  • Methods of optimizing chromatographic separation of polypeptides
    Patent number: 9766217
    Abstract: Described are methods for determination of peptide specific parameter(s) of a mixture comprising a target peptide and a related impurity (or impurities) to be used in a simulation model of chromatographic separation using mathematical model(s). Also described are chromatographic simulation methods using above determined parameters, as well as computer systems and computer programs for performing one or more of the above method(s).
    Type: Grant
    Filed: September 8, 2007
    Date of Patent: September 19, 2017
    Assignee: Novo Nordisk A/S
    Inventors: Steffen Kidal, Thomas Budde Hansen, Arne Staby
  • Reduction of the content of protein contaminants in compositions comprising a vitamin K-dependent protein of interest
    Patent number: 9187549
    Abstract: The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.
    Type: Grant
    Filed: December 23, 2005
    Date of Patent: November 17, 2015
    Assignee: Novo Nordisk Healthcare A/G
    Inventors: Janus Krarup, Thomas Budde Hansen, Anne Charlotte Arentsen, Daniel E. Rasmussen, Are Bogsnes, Arne Staby, Haleh Ahmadian, Susanne Bang
  • Purification of proteins using preparative reverse phase chromatography (RPC)
    Patent number: 8921518
    Abstract: The present invention provides a method for industrial-scale protein separation by reverse phase chromatography by use of a buffer system and an additional salt.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: December 30, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Daniel E. Rasmussen, Arne Staby, John Strikart Nielsen, Ole Schou
  • Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins
    Patent number: 8710181
    Abstract: The present invention is directed to a method for reducing the onset or incidence of gelation/fibrillation/aggregation during the up- and down-stream processing and purification of peptides, polypeptides and proteins analogs and/or derivatives thereof, including Glucagon-Like Peptides (GLPs). More particularly, the present invention relates to methods of processing and purifying such peptides, polypeptides and proteins in the presence of tris(hydroxymethyl)aminomethane.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: April 29, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Ingun Christiansen, Arne Staby
  • Ion exchange chromatography of GLP-1, analogs and derivatives thereof
    Patent number: 8067554
    Abstract: The present invention relates to an ion exchange chromatography process for purifying GLP-1 or an analog or a derivative thereof from a mixture containing said GLP-1 and related impurities, and to an industrial method including such ion exchange chromatography process.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: November 29, 2011
    Assignee: Novo Nordisk A/S
    Inventor: Arne Staby
  • ANTIBODY PURIFICATION PROCESS
    Publication number: 20110105725
    Abstract: The invention concerns a method for the industrial production of antibodies.
    Type: Application
    Filed: May 15, 2009
    Publication date: May 5, 2011
    Inventors: Bjarne Rønfeldt Nielsen, Hanne Christensen, Daniel E. Rasmussen, Thomas Budde Hansen, John Strikart Nielsen, Erik Halkjaer, Rikke Christina Nielsen, Christina Jespersgaard, Arne Staby
  • Purification of Glucagon-Like Peptides
    Publication number: 20100184687
    Abstract: Method for purifying a glucagon-like peptide by reversed phase high performance liquid chromatography.
    Type: Application
    Filed: March 17, 2010
    Publication date: July 22, 2010
    Applicant: Novo Nordisk A/S
    Inventors: Arne Staby, Camilla Kornbeck, Dorte Lunøe Dünweber, Hanne Christensen, Ole Schou
  • Methods of Optimizing Chromatographic Separation of Polypeptides
    Publication number: 20100004907
    Abstract: Described are methods for determination of peptide specific parameter(s) of a mixture comprising a target peptide and a related impurity (or impurities) to be used in a simulation model of chromatographic separation using mathematical model(s). Also described are chromatographic simulation methods using above determined parameters, as well as computer systems and computer programs for performing one or more of the above method(s).
    Type: Application
    Filed: September 8, 2007
    Publication date: January 7, 2010
    Applicant: NOVO NORDISK A/S
    Inventors: Steffen Kidal, Thomas Budde Hansen, Arne Staby
  • PURIFICATION OF PROTEINS USING PREPARATIVE REVERSE PHASE CHROMATOGRAPHY (RPC)
    Publication number: 20090036652
    Abstract: The present invention provides a method for industrial-scale protein separation by reverse phase chromatography by use of a buffer system and an additional salt.
    Type: Application
    Filed: December 21, 2006
    Publication date: February 5, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Daniel E. Rasmussen, Arne Staby, John Strikart Nielsen, Ole Schou
  • Ion exchange chromatography of GLP-1, analogs and derivatives thereof
    Publication number: 20080281078
    Abstract: The present invention relates to an ion exchange chromatography process for purifying GLP-1 or an analog or a derivative thereof from a mixture containing said GLP-1 and related impurities, and to an industrial method including such ion exchange chromatography process.
    Type: Application
    Filed: May 29, 2007
    Publication date: November 13, 2008
    Applicant: Novo Nordisk A/S
    Inventor: Arne Staby
  • Reduction of the Content of Protein Contaminents in Compositions Comprising a Vitamin K-Dependent Protein of Interest
    Publication number: 20080207880
    Abstract: The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.
    Type: Application
    Filed: December 23, 2005
    Publication date: August 28, 2008
    Applicant: Novo Nordisk HealthCare A/G
    Inventors: Janus Krarup, Thomas Budde Hansen, Anne Charlotte Arentsen, Daniel E. Rasmussen, Are Bognes, Arne Staby, Haleh Ahmadian, Susanne Bang
  • Use of Tris(Hydroxymethyl) Aminomethane For the Stabilization of Peptides, Polypeptides and Proteins
    Publication number: 20080171848
    Abstract: The present invention is directed to a method for reducing the onset or incidence of gelation/fibrillation/aggregation during the up- and down-stream processing and purification of peptides, polypeptides and proteins analogs and/or derivatives thereof, including Glucagon-Like Peptides (GLPs). More particularly, the present invention relates to methods of processing and purifying such peptides, polypeptides and proteins in the presence of tris(hydroxymethyl)aminomethane.
    Type: Application
    Filed: August 26, 2005
    Publication date: July 17, 2008
    Applicant: Novo Nordisk A/S
    Inventors: Ingun Christiansen, Arne Staby
  • Ion exchange chromatography of proteins and peptides
    Patent number: 7276590
    Abstract: The present invention relates to an ion exchange chromatography process for purifying a peptide from a mixture containing the peptide and related impurities, and to an industrial method including such ion exchange chromatography process.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: October 2, 2007
    Assignee: Novo Nordisk A/S
    Inventor: Arne Staby
  • Method for treatment of protein precipitates
    Publication number: 20070208163
    Abstract: The present invention relates to a method of washing and concentrating of protein precipitates by use of centrifugal forces. The proteins may be insulin, insulin analogues or insulin derivatives or GLP-1 or GLP-2 and analogues and derivates thereof such as acylated proteins.
    Type: Application
    Filed: January 9, 2006
    Publication date: September 6, 2007
    Applicant: Novo Nordisk A/S
    Inventors: Ole Jensen, Are Bognes, Martijn Wiertz, Arne Staby, Marc Bisschops, Tiemens Reijns
  • Purification of glucagon-like peptides
    Publication number: 20060211616
    Abstract: Method for purifying a glucagon-like peptide by reversed phase high performance liquid chromatography
    Type: Application
    Filed: February 21, 2006
    Publication date: September 21, 2006
    Applicant: Novo Nordisk A/S
    Inventors: Arne Staby, Camilia Kornbeck, Dorte Dunweber, Hanne Christensen, Ole Schou
  • Ion exchange chromatography of GLP-1, analogs and derivatives thereof
    Publication number: 20030027996
    Abstract: The present invention relates to an ion exchange chromatography process for purifying GLP-1 or an analog or a derivative thereof from a mixture containing said GLP-1 and related impurities, and to an industrial method including such ion exchange chromatography process.
    Type: Application
    Filed: June 18, 2002
    Publication date: February 6, 2003
    Inventor: Arne Staby