Patents by Inventor Arnold H. Horwitz
Arnold H. Horwitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9206252Abstract: An IL-1? binding antibody or IL-1? binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1? binding polypeptide. IL-1? binding antibodies or IL-1? binding fragments thereof are provided which have desirable affinity and potency.Type: GrantFiled: January 11, 2013Date of Patent: December 8, 2015Assignee: XOMA (US) LLCInventors: Linda Masat, Mary Haak-Frendscho, Arnold H. Horwitz, Gang Chen, Marina Roell
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Patent number: 8318162Abstract: The present disclosure relates to anti-high molecular weight melanoma associated antigen (HMW-MAA) antibodies which bind to human HMW-MAA. Such antibodies may be used to treat diseases or disorders characterized by expression of HMW-MAA including cancer, for example, melanoma, basal cell carcinoma, ALL or AML.Type: GrantFiled: July 16, 2010Date of Patent: November 27, 2012Assignee: Xoma Technology Ltd.Inventor: Arnold H. Horwitz
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Publication number: 20120178126Abstract: The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription unit encoding a polypeptide of interest separated by at least one selective marker gene and methods for sequentially transforming or transfecting host cells with expression vectors to increase transcription unit dosage and expression.Type: ApplicationFiled: August 8, 2011Publication date: July 12, 2012Applicant: XOMA TECHNOLOGY LTD.Inventor: Arnold H. Horwitz
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Publication number: 20120171226Abstract: The present disclosure relates to anti-high molecular weight melanoma associated antigen (HMW-MAA) antibodies which bind to human HMW-MAA. Such antibodies may be used to treat diseases or disorders characterized by expression of HMW-MAA including cancer, for example, melanoma, basal cell carcinoma, ALL or AML.Type: ApplicationFiled: July 16, 2010Publication date: July 5, 2012Applicant: XOMA Technology Ltd.Inventor: Arnold H. Horwitz
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Patent number: 7988968Abstract: An IL-1? binding antibody or IL-1? binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1? binding polypeptide. IL-1? binding antibodies or IL-1? binding fragments thereof are provided which have desirable affinity and potency.Type: GrantFiled: May 12, 2009Date of Patent: August 2, 2011Assignee: Xoma Technology Ltd.Inventors: Linda Masat, Mary Haak-Frendscho, Arnold H. Horwitz, Gang Chen, Marina Roell
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Patent number: 7943121Abstract: An IL-1? binding antibody or IL-1? binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1? binding polypeptide. IL-1? binding antibodies or IL-1? binding fragments thereof are provided which have desirable affinity and potency.Type: GrantFiled: May 12, 2009Date of Patent: May 17, 2011Assignee: XOMA Technology Ltd.Inventors: Linda Masat, Mary Haak-Frendscho, Arnold H. Horwitz, Gang Chen, Marina Roell
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Patent number: 7829094Abstract: Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1? binding antibody or IL-1? binding fragment thereof. An IL-1? binding antibody or IL-1? binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO: 15 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1? binding polypeptide. IL-1? binding antibodies or IL-1? binding fragments thereof are provided which have desirable affinity and potency.Type: GrantFiled: May 11, 2009Date of Patent: November 9, 2010Assignee: Xoma Technology Ltd.Inventors: Linda Masat, Mary Haak-Frendscho, Arnold H. Horwitz, Gang Chen, Marina Roell
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Patent number: 7829093Abstract: Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1? binding antibody or IL-1? binding fragment thereof. An IL-1? binding antibody or IL-1? binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO: 15 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1? binding polypeptide. IL-1? binding antibodies or IL-1? binding fragments thereof are provided which have desirable affinity and potency.Type: GrantFiled: May 11, 2009Date of Patent: November 9, 2010Assignee: Xoma Technology Ltd.Inventors: Linda Masat, Mary Haak-Frendscho, Arnold H. Horwitz, Gang Chen, Marina Roell
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Patent number: 7794976Abstract: Recombinant expression vectors are provided comprising a 3?UTR of a light chain and an Epstein-Barr virus origin of replication. Also provided are host cells comprising such vectors and methods of producing recombinant protein with such vectors. Additional methods of producing a recombinant protein involve contacting cells with a first and second vector, each of which encode a different polypeptide chain, and wherein the second vector is present in an amount which is about 1.5 to 2.5 times as much as that of the first vector. Cells also can be transfected with a recombinant transient expression vector encoding a protein and are cultured in a medium in a membrane-enhanced culturing vessel to produce recombinant protein.Type: GrantFiled: July 31, 2007Date of Patent: September 14, 2010Assignee: XOMA Technology Ltd.Inventors: Masahisa Handa, Arnold H. Horwitz, Robyn Cotter, Eddie Batista
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Patent number: 7744865Abstract: An IL-1? binding antibody or IL-1? binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 8 and SEQ ID NO: 9, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease. IL-1? binding antibodies or IL-1? binding fragments thereof are provided which have desirable affinity and potency.Type: GrantFiled: May 11, 2009Date of Patent: June 29, 2010Assignee: Xoma Technology Ltd.Inventors: Linda Masat, Mary Haak-Frendscho, Arnold H. Horwitz, Gang Chen, Marina Roell
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Patent number: 7744866Abstract: An IL-1? binding antibody or IL-1? binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 26 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease. IL-1? binding antibodies or IL-1? binding fragments thereof are provided which have desirable affinity and potency.Type: GrantFiled: May 11, 2009Date of Patent: June 29, 2010Assignee: XOMA Technology Ltd.Inventors: Linda Masat, Mary Haak-Frendscho, Arnold H. Horwitz, Gang Chen, Marina Roell
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Publication number: 20100061998Abstract: An IL-1? binding antibody or IL-1? binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1? binding polypeptide. IL-1? binding antibodies or IL-1? binding fragments thereof are provided which have desirable affinity and potency.Type: ApplicationFiled: May 12, 2009Publication date: March 11, 2010Applicant: XOMA TECHNOLOGY LTD.Inventors: Linda Masat, Mary Haak-Frendscho, Gang Chen, Arnold H. Horwitz, Marina Roell
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Publication number: 20080241126Abstract: Human engineered anti-Ep-CAM antibodies and various uses therefore are disclosed. These human engineered anti-Ep-CAM antibodies have high affinity binding to Ep-CAM with low immunogenicity.Type: ApplicationFiled: November 2, 2007Publication date: October 2, 2008Applicant: XOMA TECHNOLOGY LTD.Inventors: Marc D. Better, Arnold H. Horwitz
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Publication number: 20080145895Abstract: The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription unit encoding a polypeptide of interest separated by at least one selective marker gene and methods for sequentially transforming or transfecting host cells with expression vectors to increase transcription unit dosage and expression.Type: ApplicationFiled: August 7, 2007Publication date: June 19, 2008Applicant: XOMA TECHNOLOGY LTD.Inventor: Arnold H. Horwitz
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Patent number: 7192737Abstract: The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription unit encoding a polypeptide of interest separated by at least one selective marker gene and methods for sequentially transforming or transfecting host cells with expression vectors to increase transcription unit dosage and expression.Type: GrantFiled: March 31, 2003Date of Patent: March 20, 2007Assignee: XOMA Technology Ltd.Inventor: Arnold H. Horwitz
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Publication number: 20030203447Abstract: The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription unit encoding a polypeptide of interest separated by at least one selective marker gene and methods for sequentially transforming or transfecting host cells with expression vectors to increase transcription unit dosage and expression.Type: ApplicationFiled: March 31, 2003Publication date: October 30, 2003Inventor: Arnold H. Horwitz
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Publication number: 20030096343Abstract: The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts transformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant region modules and non-human variable region modules, or for class switching antibody molecules and/or chains.Type: ApplicationFiled: January 9, 2002Publication date: May 22, 2003Applicant: XOMA Technology Ltd.Inventors: Randy R. Robinson, Alvin Y. Liu, Arnold H. Horwitz, Marc Better, Randolph Wall, Shau-Ping Lei, Gary L. Wilcox
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Patent number: 6461824Abstract: The invention is directed to chimeric immunoglobulins that recognize a human tumor antigen bound by antibody, ING-2, ING-3, ING-4 or KM10, the production of such chimeric immunoglobulins, and their use.Type: GrantFiled: June 6, 1995Date of Patent: October 8, 2002Assignee: Xoma Technology Ltd.Inventors: Marc D. Better, Arnold H. Horwitz, Randy R. Robinson, Shau-Ping Lei, Changtung Paul Chang
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Patent number: 6204023Abstract: The invention relates to cDNA genetic sequences, vehicles containing same as well as hosts tansformed therewith, for the production of chimeric immunoglobulin molecules, functional fragments thereof and immunoglobulin derivatives exhibiting novel functional properties comprising human constant region modules and non-human variable region modules, or for class switching antibody molecules and/or chains. The invention also relates to DNA coding for pectate lyase signal peptide has been cloned on a plasmid to create a secretion vector which is capable of producing a chosen protein which is transported across the bacterial membrane. The secretion vector has been used to secrete extracellular thaumatin and extracellular chimeric antibody fragments. The proteins produced by this vector have biological activity. The thaumatin is properly folded and the antibody fragments are capable of binding antigens on target cancer cells.Type: GrantFiled: June 6, 1995Date of Patent: March 20, 2001Assignee: XOMA Ltd.Inventors: Randy R. Robinson, Alvin Y. Liu, Arnold H. Horwitz, Marc Better, Randolph Wall, Shau-Ping Lei, Gary L. Wilcox
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Patent number: 5843685Abstract: The invention is directed to a chimeric immunoglobulin that recognizes the human tumor antigen bound by antibody ING-1, its production, and use.Type: GrantFiled: June 6, 1995Date of Patent: December 1, 1998Assignee: Xoma CorporationInventors: Marc D. Better, Arnold H. Horwitz, Randy R. Robinson, Shau-Ping Lei, Changtung Paul Chang