Abstract: Articles (e.g., lateral flow assays) and methods for the detection of an analyte are generally described. The assays may involve the use of a network which blocks or restricts flow in the assay, e.g., due to formation of an interconnect network or lattice.

Abstract: Articles (e.g., lateral flow assays) and methods for the detection of an analyte are generally described. The assays may involve the use of a network which blocks or restricts flow in the assay, e.g., due to formation of an interconnect network or lattice.

Abstract: Disclosed are methods and systems for analyte detection in a sample and more particularly, a biological sample. Methods and systems particularly relate to differentiating and/or identifying cell types in biological samples, such as blood samples, by adding antibodies specific to predetermined CD antigens. Other methods and systems relate to controlling the dynamic range of an assay for analyte detection.

Abstract: A microfluidic valve assembly and a microfluidic sensing platform are provided. The valve assembly has particular utility for separating test fluids from being in contact with a soft substrate, for example, a PDMS substrate. The valve member includes a stretchable membrane positioned to seal a fluid channel. The microfluidic sensing platform is particularly suited for detecting and/or quantifying the presence of one or more target agents in a fluid sample. This system includes a microfluidic chip configured to receive a capture agent and detection agent; a controller configured to control flow of a capture agent and a detection agent; and a sensor configured to detect results of the interaction between the target agents and the mixture of the capture agent and the detection agent.

Abstract: A linker molecule and method for treating a substrate surface is provided, which includes a linker molecule with a plurality of moieties capable of resisting non-specific binding of proteins whilst permitting specific binding of a target biomolecule or a biomolecule of interest, including antibodies.

Abstract: Disclosed are methods and systems for analyte detection in a sample and more particularly, a biological sample. Methods and systems particularly relate to differentiating and/or identifying cell types in biological samples, such as blood samples, by adding antibodies specific to predetermined CD antigens. Other methods and systems relate to controlling the dynamic range of an assay for analyte detection.

Abstract: A linker molecule and method for treating a substrate surface is provided, which includes a linker molecule with a plurality of moieties capable of resisting non-specific binding of proteins whilst permitting specific binding of a target biomolecule or a biomolecule of interest, including antibodies.

Abstract: A microfluidic valve assembly and a microfluidic sensing platform are provided. The valve assembly has particular utility for separating test fluids from being in contact with a soft substrate, for example, a PDMS substrate. The valve member includes a stretchable membrane positioned to seal a fluid channel. The microfluidic sensing platform is particularly suited for detecting and/or quantifying the presence of one or more target agents in a fluid sample. This system includes a microfluidic chip configured to receive a capture agent and detection agent; a controller configured to control flow of a capture agent and a detection agent; and a sensor configured to detect results of the interaction between the target agents and the mixture of the capture agent and the detection agent.

Abstract: Disclosed are methods and systems for analyte detection in a sample and more particularly, a biological sample. Methods and systems particularly relate to differentiating and/or identifying cell types in biological samples, such as blood samples, by adding antibodies specific to predetermined CD antigens. Other methods and systems relate to controlling the dynamic range of an assay for analyte detection.