Patents by Inventor Arpad Grein

Arpad Grein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biosynthetic anthracyclines related to daunorubicin
    Patent number: 4942155
    Abstract: The novel compounds are provided with good antibacterial and antitumour activity.
    Type: Grant
    Filed: March 9, 1987
    Date of Patent: July 17, 1990
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Giuseppe Cassinelli, Arpad Grein, Sergio Merli, Giovanni Rivola
  • Antitumor antibiotics
    Patent number: 4421851
    Abstract: Anthracycline glycosides W, X, Y and Z which are prepared by the fermentation of mutant F.I. 416 of Streptomyces peucetius var. caesius. The new compounds are useful against both gram positive and gram negative bacteria and as antitumor agents.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: December 20, 1983
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Giuseppe Cassinelli, Arpad Grein, Sergio Merli, Giovanni Rivola
  • Preparation of II-deoxy anthracycline antibiotics
    Patent number: 4411834
    Abstract: Anthracycline antibiotics of the formula: ##STR1## wherein R is --CO--CH.sub.2 OH, --CHOH--CH.sub.3, --CO--CH.sub.3 or --CH.sub.2 --CH.sub.3 having antitumor and antibacterial activity are prepared by culturing a new mutant strain of microorganism designated as Micromonospora peucetica sp. nova and which has been deposited with the American Type Culture Collection under number No. 31366 ATCC.
    Type: Grant
    Filed: September 2, 1981
    Date of Patent: October 25, 1983
    Assignee: Farmitalia Carlo Erba, S.p.A.
    Inventors: Giuseppe Cassinelli, Arpad Grein, Sergio Merli, Giovanni Rivola
  • 11-Deoxy-carminomycin compounds
    Patent number: 4370474
    Abstract: Anthracycline glycosides W, X, Y and Z which are prepared by the fermentation of mutant F.I. 416 of Streptomyces peucetius var. caesius. The new compounds are useful against both gram positive and gram negative bacteria and as antitumor agents.
    Type: Grant
    Filed: November 15, 1979
    Date of Patent: January 25, 1983
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Giuseppe Cassinelli, Arpad Grein, Sergio Merli, Giovanni Rivola
  • Preparation of 11-deoxy anthracycline antibiotics
    Patent number: 4309503
    Abstract: Anthracycling antibiotics of the formula: ##STR1## wherein R is --CO--CH.sub.2 OH, --CHOH--CH.sub.3, --CO--CH.sub.3 or --CH.sub.2 --CH.sub.3 having antitumor and antibacterial activity are prepared by culturing a new mutant strain of microorganism designated as Macromonospora peucetica sp. nova and which has been deposited with the American Type Culture Collection under numbr No. 31366 ATCC.
    Type: Grant
    Filed: October 5, 1979
    Date of Patent: January 5, 1982
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Giuseppe Cassinelli, Arpad Grein, Sergio Merli, Giovanni Rivola
  • 11-Deoxy anthracycline antibiotics, their preparation and use
    Patent number: 4247545
    Abstract: Anthracycline antibiotics of the formula: ##STR1## wherein R is --CO--CH.sub.2 OH, --CHOH--CH.sub.3, --CO--CH.sub.3 or --CH.sub.2 --CH.sub.3 having antitumor and antibacterial activity are prepared by culturing a new mutant strain of microorganism designated as Micromonospora peucetica sp. nova and which has been deposited with the American Type Culture Collection under number No. 31366 ATCC.
    Type: Grant
    Filed: February 5, 1979
    Date of Patent: January 27, 1981
    Inventors: Giuseppe Cassinelli, Arpad Grein, Sergio Merli, Giovanni Rivola
  • Process of preparation of antibiotic F.I. 1762 derivatives
    Patent number: 4012284
    Abstract: 1. A process for the preparation of a new antibiotic F.I. 1762, which comprises cultivating the Streptomyces 1762 under aerobic conditions in a liquid nutrient medium containing a carbon source, a nitrogen source and mineral salts, at a temperature between 25.degree. and 37.degree. C, over a period of time from 3 to 7 days, and extracting the formed antibiotic from the fermentation broth at a pH between 8 and 9 by means of a water-immiscible solvent, isolating and purifying the antibiotic F.I. 1762.
    Type: Grant
    Filed: October 6, 1964
    Date of Patent: March 15, 1977
    Assignee: Societa' Farmaceutici Italia, S.p.A.
    Inventors: Aurelio Di Marco, Graziana Canevazzi, Arpad Grein, Piergiuseppe Orezzi, Marcello Gaetani