Patents by Inventor Arshad Quadri
Arshad Quadri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230014100Abstract: A replacement heart valve includes an expandable frame for engaging a native valve annulus and a valve body positioned within the expandable frame. The valve body has an upstream end and a downstream end, wherein a diameter at the downstream end is greater than a diameter at the upstream end. The replacement heart valve also includes an elongate upstream portion having an inflow diameter, a transition portion that flares outwardly, and a downstream portion configured to engage a native valve annulus.Type: ApplicationFiled: September 23, 2022Publication date: January 19, 2023Inventors: Arshad Quadri, J. Brent Ratz
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Publication number: 20220331102Abstract: Devices, systems and methods are described herein a prosthesis for implantation within a lumen or body cavity and delivery systems for delivering the prosthesis to a location for implantation. A delivery system can include a plurality of components, including a flexible nose cone, multi-layer sheath, and pre-compressed shaft, which can be moveable relative to each other.Type: ApplicationFiled: June 29, 2022Publication date: October 20, 2022Applicant: Edwards Lifesciences CardiAQ LLCInventors: Arshad Quadri, J. Brent Ratz, Yen Liao, Julio Cesar Sanchez, Alexander H. Cooper, Glen T. Rabito, Siddharth Vad, Luca Pesce, Kevin M. Stewart, David Robert Landon
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Publication number: 20220323207Abstract: A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.Type: ApplicationFiled: June 28, 2022Publication date: October 13, 2022Applicant: Edwards Lifesciences CardiAQ LLCInventors: Arshad Quadri, J. Brent Ratz
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Patent number: 11452597Abstract: A replacement heart valve can have an expandable frame configured to engage a native valve annulus. A valve body can be mounted onto the expandable frame to provide functionality similar to a natural valve. The valve body has an upstream end and a downstream end, and a diameter at the downstream end is greater than a diameter at the upstream end.Type: GrantFiled: March 19, 2020Date of Patent: September 27, 2022Assignee: Edwards Lifesciences CardiAQ LLCInventors: Arshad Quadri, J. Brent Ratz
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Patent number: 11432924Abstract: A prosthetic cardiac valve comprises an anchor having an atrial skirt, an annular region, and a ventricular skirt. The prosthetic valve also has a plurality of prosthetic valve leaflets each having a first end and a free end. The first end is coupled with the anchor and the free end is opposite the first end. The prosthetic cardiac valve has an open configuration in which the free ends of the prosthetic valve leaflets are disposed away from one another to allow antegrade blood flow therepast, and a closed configuration in which the free ends of the prosthetic valve leaflets engage one another and substantially prevent retrograde blood flow therepast. The anchor has a collapsed configuration for delivery to the heart and an expanded configuration for anchoring the prosthetic cardiac valve to a patient's heart.Type: GrantFiled: October 21, 2019Date of Patent: September 6, 2022Assignees: Neovasc Tiara Inc., Edwards Lifesciences CardiAQ LLCInventors: Randy Matthew Lane, Colin A. Nyuli, Jeremy Brent Ratz, Arshad Quadri
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Patent number: 11419720Abstract: A prosthetic cardiac valve comprises an anchor having an atrial skirt, an annular region, and a ventricular skirt. The prosthetic valve also has a plurality of prosthetic valve leaflets each having a first end and a free end. The first end is coupled with the anchor and the free end is opposite the first end. The prosthetic cardiac valve has an open configuration in which the free ends of the prosthetic valve leaflets are disposed away from one another to allow antegrade blood flow therepast, and a closed configuration in which the free ends of the prosthetic valve leaflets engage one another and substantially prevent retrograde blood flow therepast. The anchor has a collapsed configuration for delivery to the heart and an expanded configuration for anchoring the prosthetic cardiac valve to a patient's heart.Type: GrantFiled: September 3, 2019Date of Patent: August 23, 2022Assignees: Neovasc Tiara Inc., Edwards Lifesciences CardiAQ LLCInventors: Randy Matthew Lane, Colin A. Nyuli, Jeremy Brent Ratz, Arshad Quadri
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Publication number: 20220249225Abstract: A prosthesis can comprise an expandable frame, a plurality of distal anchors and a plurality of proximal anchors. The anchors can extend outwardly from the frame. The frame can be configured to radially expand and contract for deployment within a body cavity. The frame and anchors can have one of many different shapes and configurations. For example, when the frame is in an expanded configuration, the frame can have a larger cross-sectional dimension in a middle portion of the frame and a smaller cross-sectional dimension in a proximal portion and a distal portion of the frame, wherein the middle portion is between the proximal and distal portions. As another example, the anchors can have looped ends, the entire anchor may loop out from the frame.Type: ApplicationFiled: April 29, 2022Publication date: August 11, 2022Applicant: Edwards Lifesciences CardiAQ LLCInventors: J. Brent Ratz, Arshad Quadri, Luca Pesce
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Patent number: 11389292Abstract: Devices, systems and methods are described herein a prosthesis for implantation within a lumen or body cavity and delivery systems for delivering the prosthesis to a location for implantation. A delivery system can include a plurality of components, including a flexible nose cone, multi-layer sheath, and pre-compressed shaft, which can be moveable relative to each other.Type: GrantFiled: July 19, 2019Date of Patent: July 19, 2022Assignee: Edwards Lifesciences CardiAQ LLCInventors: Arshad Quadri, J. Brent Ratz, Yen Liao, Julio Cesar Sanchez, Alexander H. Cooper, Glen T. Rabito, Siddharth Vad, Luca Pesce, Kevin M. Stewart, David Robert Landon
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Patent number: 11376119Abstract: A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.Type: GrantFiled: October 14, 2019Date of Patent: July 5, 2022Assignee: Edwards Lifesciences CardiAQ LLCInventors: Arshad Quadri, J. Brent Ratz
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Publication number: 20220151782Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. A delivery component can have a plurality of slots that provide for desired bending of the delivery component, particularly compound bending of the delivery component that can facilitate steering of the delivery component in three dimensions.Type: ApplicationFiled: February 7, 2022Publication date: May 19, 2022Applicant: Edwards Lifesciences CardiAQ LLCInventors: Alexander H. Cooper, David Robert Landon, Julio Cesar Sanchez, Glen T. Rabito, J. Brent Ratz, Arshad Quadri, Kevin M. Stewart, Patrick Chow
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Patent number: 11324591Abstract: A prosthesis can comprise an expandable frame, a plurality of distal anchors and a plurality of proximal anchors. The anchors can extend outwardly from the frame. The frame can be configured to radially expand and contract for deployment within a body cavity. The frame and anchors can have one of many different shapes and configurations. For example, when the frame is in an expanded configuration, the frame can have a larger cross-sectional dimension in a middle portion of the frame and a smaller cross-sectional dimension in a proximal portion and a distal portion of the frame, wherein the middle portion is between the proximal and distal portions. As another example, the anchors can have looped ends, the entire anchor may loop out from the frame.Type: GrantFiled: February 6, 2020Date of Patent: May 10, 2022Assignee: Edwards Lifesciences CardiAQ LLCInventors: J. Brent Ratz, Arshad Quadri, Luca Pesce
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Patent number: 11324594Abstract: This disclosure relates generally to prosthetic valves and methods and systems for deploying, positioning, and recapturing the same. A prosthetic valve includes one or more support structures. At least one of the one or more support structures defines an elongate central passageway of the prosthetic valve. The prosthetic valve can also include a plurality of leaflet elements attached to at least one of the one or more support structures and disposed within the elongate central passageway for control of fluid flow through the elongate central passageway. At least one of the one or more support structures is configured to biodynamically fix the prosthetic valve within a native valve such as, for example, a native tricuspid valve of a heart.Type: GrantFiled: March 31, 2020Date of Patent: May 10, 2022Assignee: inQB8 Medical Technologies, LLCInventors: J. Brent Ratz, Arshad Quadri
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Publication number: 20220087816Abstract: Described herein are prosthetic heart valves and methods for improving the functionality of native heart valves. An exemplary prosthetic heart valve may include one or more support structures, in which at least one support structure defines an elongate central passageway having a longitudinal. The prosthetic heart valve may include a plurality of leaflet elements attached to the at least one support structure and disposed within the elongate central passageway for control of blood flow through the elongate central passageway. The at least one support structure may be configured to biodynamically fix the prosthetic heart valve to native leaflets of a native heart valve of a heart.Type: ApplicationFiled: August 27, 2021Publication date: March 24, 2022Applicant: inQB8 Medical Technologies, LLCInventors: J. Brent Ratz, Arshad Quadri, Christopher Stivers
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Patent number: 11253364Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. A delivery component can have a plurality of slots that provide for desired bending of the delivery component, particularly compound bending of the delivery component that can facilitate steering of the delivery component in three dimensions.Type: GrantFiled: June 20, 2019Date of Patent: February 22, 2022Assignee: Edwards Lifesciences CardiAQ LLCInventors: Alexander H. Cooper, David Robert Landon, Julio Cesar Sanchez, Glen T. Rabito, J. Brent Ratz, Arshad Quadri, Kevin M. Stewart, Patrick Chow
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Publication number: 20220023039Abstract: A two-part heart valve prosthesis comprising a self-expanding valve cage stent and a bi-leaflet tissue valve secured thereto. A method for delivering a heart valve prosthesis to a native valve annulus comprises expanding an expandable frame at the native valve annulus and positioning a replacement heart valve within the expandable frame. The expandable frame preferably includes a first anchoring portion that is positioned on a first side of the native valve annulus and a second anchoring portion that is positioned on a second side of the native valve annulus. The first anchoring portion engages tissue on the first side of the native valve annulus and the second anchoring portion engages tissue on the second side of the native valve annulus for securing the expandable frame to the native valve annulus. The replacement heart valve comprises a plurality of leaflets for replacing the function of the native valve.Type: ApplicationFiled: October 5, 2021Publication date: January 27, 2022Applicant: Edwards Lifesciences CardiAQ LLCInventor: Arshad Quadri
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Publication number: 20210378822Abstract: This disclosure relates generally to prosthetic valves and methods and systems for deploying, positioning, and recapturing the same. A prosthetic valve includes one or more support structures. At least one of the one or more support structures defines an elongate central passageway of the prosthetic valve. The prosthetic valve can also include a plurality of leaflet elements attached to at least one of the one or more support structures and disposed within the elongate central passageway for control of fluid flow through the elongate central passageway. At least one of the one or more support structures is configured to biodynamically fix the prosthetic valve within a native valve such as, for example, a native tricuspid valve of a heart.Type: ApplicationFiled: June 11, 2021Publication date: December 9, 2021Applicant: inQB8 Medical Technologies, LLCInventors: J. Brent Ratz, Arshad Quadri
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Patent number: 11141265Abstract: A method for delivering a heart valve prosthesis to a native valve annulus comprises expanding an expandable frame at the native valve annulus and positioning a replacement heart valve within the expandable frame. The expandable frame preferably includes a first anchoring portion that is positioned on a first side of the native valve annulus and a second anchoring portion that is positioned on a second side of the native valve annulus. The first anchoring portion engages tissue on the first side of the native valve annulus and the second anchoring portion engages tissue on the second side of the native valve annulus for securing the expandable frame to the native valve annulus. The replacement heart valve comprises a plurality of leaflets for replacing the function of the native valve.Type: GrantFiled: July 3, 2019Date of Patent: October 12, 2021Assignee: Edwards Lifesciences CardiAQ LLCInventor: Arshad Quadri
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Publication number: 20210307894Abstract: A system for treating aortic dissection including an aortic dissection implant comprising an expandable anchoring structure and an elongate tubular structure. The expandable anchoring structure can be configured to apply radial force to the sinuses of the aortic root and/or the sinotubular junction when expanded. The elongate tubular structure can comprise an expandable support frame and one or more layers. The expandable support frame can be configured to extend from the descending aorta to the ascending aorta and curve along with a curvature of the aortic arch when expanded within the aorta. The one or more layers can comprise a first porous layer comprising an atraumatic outer surface positioned over the expandable support frame and a second non-porous layer positioned over a portion of the first porous layer. The second non-porous layer may be configured to be positioned on opposite sides of the aortic dissection and to be inflatable via blood flow to seal against the dissection.Type: ApplicationFiled: January 8, 2021Publication date: October 7, 2021Inventors: Arshad QUADRI, J. Brent RATZ, Christopher William Stivers
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Publication number: 20210299430Abstract: A system for treating atrial dysfunction, including heart failure and/or atrial fibrillation, that includes one or more pressurizing elements and control circuitry. The one or more pressurizing elements can comprise one or more balloons and can be configured to be positioned in the left atrium, and optionally the pulmonary artery, of a patient's heart. The one or more pressurizing elements can be coupled to one or more positioning structures that can be configured to position the one or more pressurizing elements in the left atrium, and optionally the pulmonary artery. The control circuitry can be configured to operate the one or more pressurizing elements to decrease or increase pressure and/or volume in the left atrium, and optionally the pulmonary artery, in accordance with different phases of the cardiac cycle.Type: ApplicationFiled: January 8, 2021Publication date: September 30, 2021Inventors: J. Brent Ratz, Arshad Quadri
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Publication number: 20210298902Abstract: This disclosure relates generally to prosthetic valves and methods and systems for deploying, positioning, and recapturing the same. A prosthetic valve includes one or more support structures. At least one of the one or more support structures defines an elongate central passageway of the prosthetic valve. The prosthetic valve can also include a plurality of leaflet elements attached to at least one of the one or more support structures and disposed within the elongate central passageway for control of fluid flow through the elongate central passageway. At least one of the one or more support structures is configured to biodynamically fix the prosthetic valve within a native valve such as, for example, a native tricuspid valve of a heart.Type: ApplicationFiled: June 14, 2021Publication date: September 30, 2021Applicant: inQB8 Medical Technologies, LLCInventors: J. Brent Ratz, Arshad Quadri