Patents by Inventor Artak Tovmasyan

Artak Tovmasyan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluoro substituted porphyrin compounds, pharmaceutical compositions comprising the same, and methods of preparing and using the same
    Patent number: 11344574
    Abstract: Provided herein are fluoro-substituted porphyrin compounds, such as those having a structure represented by Formula (I), wherein R1 is a C1-C8 alkyl that is substituted with at least 1 fluorine (e.g., a C1-C8 alkyl substituted with 1-17 fluorine atoms); and X is an anion (e.g. a halogen ion (e.g., chloride, etc.), PF6, tosylate, besylate, and/or mesylate). Also provided herein are methods of making the fluoro-substituted porphyrin compounds, pharmaceutical formulations containing the same, and methods of use thereof.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: May 31, 2022
    Assignee: Duke University
    Inventors: Ines Batinic-Haberle, Artak Tovmasyan, Ivan Spasojevic
  • FLUORO SUBSTITUTED PORPHYRIN COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME
    Publication number: 20210361702
    Abstract: Provided herein are fluoro-substituted porphyrin compounds, such as those having a structure represented by Formula (I), wherein R1 is a C1-C8 alkyl that is substituted with at least 1 fluorine (e.g., a C1-C8 alkyl substituted with 1-17 fluorine atoms); and X is an anion (e.g. a halogen ion (e.g., chloride, etc.), PF6, tosylate, besylate, and/or mesylate). Also provided herein are methods of making the fluoro-substituted porphyrin compounds, pharmaceutical formulations containing the same, and methods of use thereof.
    Type: Application
    Filed: September 26, 2018
    Publication date: November 25, 2021
    Inventors: Ines Batinic-Haberle, Artak Tovmasyan, Ivan Spasojevic
  • METHODS OF MAKING SUBSTITUTED PORPHYRIN PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS
    Publication number: 20190330220
    Abstract: Described herein are methods and intermediates useful for making substituted porphyrins, including Mn(III) orthoN-butoxyethylpyridylporphyrin, and compositions comprising the same. In some embodiments, a method of the present invention provides a composition having a certain percentage or yield (e.g., at least 80%, 85%, 90%, or 95% by weight) of a compound of the present invention.
    Type: Application
    Filed: December 19, 2017
    Publication date: October 31, 2019
    Inventors: Ines Batinic-Haberle, Artak Tovmasyan, Zrinka Rajic Dzolic, Ivan Spasojevic, Christopher Allen Lee
  • Method for fluorescent staining of cellular and intracellular membranes
    Patent number: 9034596
    Abstract: The method for fluorescent staining of cellular and intracellular membranes includes contacting a cell sample, such as a cell culture, with a fluorescent probe including Zn(II) meso-tetrakis(N-n-hexylpyridinium-4-yl)porphyrin tetrachloride (ZnTnHex-4-PyPCl4). The fluorescent probe is an amphiphilic, water-soluble compound. The fluorescent probe does not interfere with cell culture media components or other staining products. The fluorescent probe is not harmful to cells.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: May 19, 2015
    Assignee: KUWAIT UNIVERSITY
    Inventors: Ludmil Tzvetanov Benov, Rima Abdul Ghani Ezzeddine, Anwar Gh. A. Gh. Albanaw, Ines Batinic-Haberle, James D. Craik, Artak Tovmasyan