Abstract: Systems and methods for improving or incentivizing patient compliance with a medical schedule are disclosed. A system can include a medication module and a sensing system. The medication module can be communicatively coupleable to a portable device and can include at least one compartment for storing and dispensing one or more doses of a medication in accordance with a medication program. The sensing mechanism can be associated with the medication module and can be configured to detect a medication dispensing activity from the compartment. The system can further include a portable device including an electronic communication module, which is configured to receive and provide to a user and at least one third party dosage or compliance information about the medication program, and a user-interface, which is configured to display the dosage or compliance information about the medication program to the user and receive data input from the user.