Patents by Inventor Arthur Leo Kruckeberg
Arthur Leo Kruckeberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9909148Abstract: The invention relates to the fields of industrial microbiology and alcohol production. The invention also relates to the development of a microorganism capable of producing fermentation products via an engineered pathway, and uses of the microorganism. The invention also relates to the methods to improve cell viability and productivity and the use of recycling and acid washing to increase the yield of fermentation products.Type: GrantFiled: December 28, 2012Date of Patent: March 6, 2018Assignee: Butamax Advanced Biofuels LLCInventors: Bhaskar Bhadra, Ritu Bhalla, Arthur Leo Kruckeberg, Vasantha Nagarajan, Ranjan Patnaik, Wonchul Suh
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Patent number: 9790521Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.Type: GrantFiled: March 23, 2012Date of Patent: October 17, 2017Assignee: Butamax Advanced Biofuels LLCInventors: Larry Cameron Anthony, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica McElvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
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Patent number: 9422581Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.Type: GrantFiled: March 15, 2013Date of Patent: August 23, 2016Assignee: Butamax Advanced Biofuels LLCInventors: Larry Cameron Anthony, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica McElvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
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Patent number: 9422582Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.Type: GrantFiled: March 15, 2013Date of Patent: August 23, 2016Assignee: Butamax Advanced Biofuels LLCInventors: Larry Cameron Anthony, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica McElvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
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Patent number: 9181566Abstract: The invention relates to suitable screening strategies for evaluating various candidate promoters for differential gene expression during the propagation and production phases of a fermentation process. The invention also relates to recombinant host cells that comprise identified promoter nucleic acid sequences and methods for producing fermentation products employing the same.Type: GrantFiled: December 28, 2012Date of Patent: November 10, 2015Assignee: BUTAMAX ADVANCED BIOFUELS LLCInventors: Michael Dauner, Arthur Leo Kruckeberg, Robert A Larossa, Brian James Paul, Wonchul Suh, Joseph Frederich Tuminello
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Publication number: 20150037855Abstract: The invention relates to the fields of industrial microbiology and alcohol production. The invention also relates to the development of a microorganism capable of producing fermentation products via an engineered pathway, and uses of the microorganism. The invention also relates to the methods to improve cell viability and productivity and the use of recycling and acid washing to increase the yield of fermentation products.Type: ApplicationFiled: December 28, 2012Publication date: February 5, 2015Inventors: Bhaskar Bhadra, RITU Bhalla, Arthur Leo Kruckeberg, Vasantha Nagarajan, Ranjan Patnaik, Wonchul Suh
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Publication number: 20140256020Abstract: Disclosed herein are methods of producing alcohol esters during a fermentation by providing alcohol-producing microorganisms which further comprise an engineered polynucleotide encoding a polypeptide having lipase activity.Type: ApplicationFiled: May 12, 2014Publication date: September 11, 2014Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventors: Robert DICOSIMO, Arthur Leo Kruckeberg, Thomas Edwin Van Aken
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Publication number: 20140186911Abstract: Provided herein are recombinant yeast cells comprising a deletion or disruption in an endogenous gene encoding Amn1 and a heterologous gene encoding Amn1. Also provided are recombinant yeast cells comprising a heterologous gene encoding Amn1 and an engineered butanol biosynthetic pathway. Further provided are methods of producing isobutanol comprising providing the recombinant yeast cells described herein and culturing the recombinant yeast cells under conditions wherein isobutanol is produced.Type: ApplicationFiled: December 20, 2013Publication date: July 3, 2014Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventors: Arthur Leo Kruckeberg, Larry Cameron Anthony
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Patent number: 8765425Abstract: Disclosed herein are methods of producing alcohol esters during a fermentation by providing alcohol-producing microorganisms which further comprise an engineered polynucleotide encoding a polypeptide having lipase activity.Type: GrantFiled: March 23, 2012Date of Patent: July 1, 2014Assignee: Butamax Advanced Biofuels LLCInventors: Robert Dicosimo, Arthur Leo Kruckeberg, Thomas Edwin Van Aken
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Patent number: 8759044Abstract: Disclosed herein are methods of producing alcohol esters during a fermentation by providing alcohol-producing microorganisms which further comprise an engineered polynucleotide encoding a polypeptide having lipase activity.Type: GrantFiled: June 15, 2012Date of Patent: June 24, 2014Assignee: Butamax Advanced Biofuels LLCInventors: Robert DiCosimo, Arthur Leo Kruckeberg, Thomas Edwin Van Aken
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Publication number: 20140162344Abstract: Disclosed herein are methods of producing alcohol esters during a fermentation by providing alcohol-producing microorganisms which further comprise an engineered polynucleotide encoding a polypeptide having lipase activity.Type: ApplicationFiled: February 14, 2014Publication date: June 12, 2014Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventors: Robert DICOSIMO, Arthur Leo Kruckeberg, Thomas Edwin Van Aken
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Publication number: 20140141479Abstract: The invention relates to a recombinant host cell having (a) a modification in an endogenous polynucleotide encoding a polypeptide having dual-role hexokinase activity; (b) a heterologous polynucleotide encoding a polypeptide having hexose kinase activity; and optionally (c) a modification in an endogenous polynucleotide encoding a polypeptide having pyruvate decarboxylase activity. Additionally, the invention relates to methods of making and using such recombinant host cells including, for example, methods of increasing glucose consumption, methods of improving redox balance, and/or methods of increasing the production of a product of a pyruvate-utilizing pathway.Type: ApplicationFiled: January 24, 2014Publication date: May 22, 2014Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLCInventors: Larry Cameron Anthony, Arthur Leo Kruckeberg, Brian James Paul
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Patent number: 8637289Abstract: The invention relates to a recombinant host cell having (a) a modification in an endogenous polynucleotide encoding a polypeptide having dual-role hexokinase activity; (b) a heterologous polynucleotide encoding a polypeptide having hexose kinase activity; and optionally (c) a modification in an endogenous polynucleotide encoding a polypeptide having pyruvate decarboxylase activity. Additionally, the invention relates to methods of making and using such recombinant host cells including, for example, methods of increasing glucose consumption, methods of improving redox balance, and/or methods of increasing the production of a product of a pyruvate-utilizing pathway.Type: GrantFiled: December 29, 2010Date of Patent: January 28, 2014Assignee: Butamax(TM) Advanced Biofuels LLCInventors: Larry Cameron Anthony, Arthur Leo Kruckeberg
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Publication number: 20130157324Abstract: Disclosed herein are methods of producing alcohol esters during a fermentation by providing alcohol-producing microorganisms which further comprise an engineered polynucleotide encoding a polypeptide having lipase activity.Type: ApplicationFiled: June 15, 2012Publication date: June 20, 2013Applicant: BUTAMAX (TM) ADVANCED BIOFUELS LLCInventors: Robert DICOSIMO, Arthur Leo Kruckeberg, Thomas Edwin Van Aken
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Publication number: 20130071898Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.Type: ApplicationFiled: March 23, 2012Publication date: March 21, 2013Applicant: Butamax(TM) Advanced Biofuels LLCInventors: LARRY CAMERON ANTHONY, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica Mcelvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
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Publication number: 20130071891Abstract: Disclosed herein are methods of producing alcohol esters during a fermentation by providing alcohol-producing microorganisms which further comprise an engineered polynucleotide encoding a polypeptide having lipase activity.Type: ApplicationFiled: March 23, 2012Publication date: March 21, 2013Applicant: Butamax(TM) Advanced Biofuels LLCInventors: ROBERT DICOSIMO, Arthur Leo Kruckeberg, Thomas Edwin Van Aken
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Publication number: 20130035515Abstract: The invention relates generally to the field of industrial microbiology and butanol production from sources of 5-carbon sugars such as lignocellulosic hydrolysates. More specifically, the invention relates to the use of an xylulose or xylulose-5-phosphate-producing enzyme and micro-aerobic or anaerobic conditions to increase butanol production from such sugars and recovery of said butanol through ins situ product recovery methods.Type: ApplicationFiled: June 15, 2012Publication date: February 7, 2013Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLCInventors: Ian David Dobson, Arthur Leo Kruckeberg
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Publication number: 20120258873Abstract: The invention relates generally to the field of industrial microbiology and butanol production. More specifically, the invention relates methods of reducing 2,3-dihydroxy-2-methyl butyrate (DHMB) in butanol production. DHMB can be reduced by inhibiting the reduction of acetolactate to DHMB, for example, by knocking out enzymes that catalyze the reduction or by removing DHMB during or after fermentation. Yeast strains, compositions, and methods for reducing DHMB and increasing butanol yield are provided.Type: ApplicationFiled: June 6, 2011Publication date: October 11, 2012Applicant: Butamax(TM) Advanced Biofuels LLCInventors: KATHARINE J. GIBSON, Arthur Leo Kruckeberg, Lori Ann Maggio-Hall, Mark J. Nelson, Ranjan Patnaik
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Publication number: 20120015416Abstract: The invention relates to a recombinant host cell having (a) a modification in an endogenous polynucleotide encoding a polypeptide having dual-role hexokinase activity; (b) a heterologous polynucleotide encoding a polypeptide having hexose kinase activity; and optionally (c) a modification in an endogenous polynucleotide encoding a polypeptide having pyruvate decarboxylase activity. Additionally, the invention relates to methods of making and using such recombinant host cells including, for example, methods of increasing glucose consumption, methods of improving redox balance, and/or methods of increasing the production of a product of a pyruvate-utilizing pathway.Type: ApplicationFiled: December 29, 2010Publication date: January 19, 2012Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLCInventors: Larry Cameron Anthony, Arthur Leo Kruckeberg
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Patent number: 7960143Abstract: Described is the production of proteins in a host cell. Even more specifically, described are methods for improving expression of two or more proteins in a cells or host cell. The methods are suited for production of, for example, recombinant antibodies that can be used in pharmaceutical preparations or as diagnostic tools. In certain embodiments, provided are methods for obtaining a cell that expresses two or more proteins comprising providing the cell with two or more protein expression units encoding two or more proteins, characterized in that at least two of the protein expression units comprise at least one STAR sequence.Type: GrantFiled: October 26, 2007Date of Patent: June 14, 2011Assignee: Chromagenics B.V.Inventors: Arie Pieter Otte, Arthur Leo Kruckeberg, Richard George Antonius Bernardus Sewalt