Patents by Inventor Arthur O. Tzianabos
Arthur O. Tzianabos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220160728Abstract: Provided are methods for reducing the risk of occurrence and/or the severity of transaminitis in a subject that is receiving a gene therapy.Type: ApplicationFiled: November 5, 2021Publication date: May 26, 2022Inventors: Janet Nancy ILES-SOMARATNE, Gabriel M. Cohn, Steven Alan Glyman, Arthur O. Tzianabos
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Publication number: 20160160237Abstract: Preparations and methods of producing a concentrated mitochondrial preparation using inverted phase centrifugation are disclosed. The methods include centrifuging a closed-bottom tube containing a heavy phase including a mitochondrial suspension in the portion of the tube proximal to the axis of rotation and a light phase in the portion of the tube distal to the axis of rotation. The centrifugation causes the suspension to form a concentrated mitochondrial layer at the interface between the heavy layer and the light layer, and the fluid at this interface is collected to produce the concentrated mitochondrial preparation. The concentrated mitochondrial preparation can be used for various applications, including in vitro fertilization applications.Type: ApplicationFiled: December 4, 2015Publication date: June 9, 2016Inventors: Colleen M. BURGESS, Scott CHAPPEL, Arthur O. TZIANABOS
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Patent number: 9265790Abstract: Methods and products for treating and protecting against asthma and allergic conditions are provided. The methods and products are related to certain naturally occurring and synthetic zwitterionic polymers which are found to induce certain T regulatory (Treg) cells and to exert immunosuppressive effects in vitro and in vivo.Type: GrantFiled: October 2, 2013Date of Patent: February 23, 2016Assignee: The Brigham and Women's Hospital, Inc.Inventors: Arthur O. Tzianabos, Dennis L. Kasper
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Publication number: 20140099331Abstract: Methods and products for treating and protecting against asthma and allergic conditions are provided. The methods and products are related to certain naturally occurring and synthetic zwitterionic polymers which are found to induce certain T regulatory (Treg) cells and to exert immunosuppressive effects in vitro and in vivo.Type: ApplicationFiled: October 2, 2013Publication date: April 10, 2014Applicant: The Brigham and Women's Hospital, Inc.Inventors: Arthur O. Tzianabos, Dennis L. Kasper
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Publication number: 20120315264Abstract: Methods and products for treating and protecting against asthma and allergic conditions are provided. The methods and products are related to certain naturally occurring and synthetic zwitterionic polymers which are found to induce certain T regulatory (Treg) cells and to exert immunosuppressive effects in vitro and in vivo.Type: ApplicationFiled: December 12, 2011Publication date: December 13, 2012Applicant: The Brigham and Women's Hospital, Inc.Inventors: Arthur O. Tzianabos, Dennis L. Kasper
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Publication number: 20110059125Abstract: Methods and products for treating and protecting against asthma and allergic conditions are provided. The methods and products are related to certain naturally occurring and synthetic zwitterionic polymers which are found to induce certain T regulatory (Treg) cells and to exert immunosuppressive effects in vitro and in vivo.Type: ApplicationFiled: April 6, 2010Publication date: March 10, 2011Applicant: The Brigham and Women's Hospital, Inc.Inventors: Arthur O. Tzianabos, Dennis L. Kasper
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Publication number: 20100303861Abstract: The invention provides live attenuated avirulent strains of Francisella tularensis, as well as methods for their preparation and use in protecting a mammal against infection with F. tularensis and against tularemia.Type: ApplicationFiled: September 22, 2006Publication date: December 2, 2010Applicant: President and Fellows of Harvard CollegeInventors: Arthur O. Tzianabos, Dennis L. Kasper, Shite Sebastian, Eric Rubin, Simon T. Dillon
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Patent number: 7803602Abstract: The present invention is directed to methods for producing and selecting new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to new res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.Type: GrantFiled: August 20, 2007Date of Patent: September 28, 2010Assignee: The Brigham and Woman's Hospital, Inc.Inventors: Laurie E. Comstock, Katja G. Weinacht, Michael J. Coyne, Dennis L. Kasper, Arthur O. Tzianabos
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Patent number: 7678558Abstract: The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.Type: GrantFiled: January 17, 2007Date of Patent: March 16, 2010Assignee: The Brigham and Women's Hospital, Inc.Inventors: Laurie E. Comstock, Katja G. Weinacht, Michael J. Coyne, Dennis L. Kasper, Arthur O. Tzianabos
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Patent number: 7456220Abstract: The invention relates to immunomodulatory compositions and related methods. The immunomodulatory compositions of a formula disclosed herein are useful for the prevention of sepsis and the treatment and prevention of diseases associated with inflammation and/or NOS.Type: GrantFiled: July 7, 2005Date of Patent: November 25, 2008Assignees: Genzyme Corporation, The Brigham and Women's Hospital, Inc.Inventors: Pericles Calias, Robert J. Miller, Andrew B. Onderdonk, Arthur O. Tzianabos
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Patent number: 7166455Abstract: The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.Type: GrantFiled: March 13, 2003Date of Patent: January 23, 2007Assignee: The Brigham and Women's Hospital, Inc.Inventors: Laurie E. Comstock, Michael J. Coyne, Dennis L. Kasper, Arthur O. Tzianabos, Katja G. Weinacht
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Patent number: 7083777Abstract: A pharmaceutical composition consisting of identical repeating units, each unit having a charge motif composed of a positively charged free amino moiety and a negatively charged moiety, wherein the positively charged free amino moiety and the negatively charged moiety of each charge motif are separated by at least one neutral amino acid, and wherein the positively charged free amino moiety of one of the charge motifs is separated by a distance of at least 8 amino acids from the positively charged amino moiety of another charge motif, and a pharmaceutically acceptable carrier. Said pharmaceutical composition is useful for inducing IL-2, activating T cells to produce a T helper 1 cytokine profile, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and/or protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation.Type: GrantFiled: March 31, 2000Date of Patent: August 1, 2006Assignee: The Brigham and Women's Hospital, Inc.Inventors: Arthur O. Tzianabos, Dennis L. Kasper, Andrew B. Onderdonk, Ying Wang
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Patent number: 7026285Abstract: Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.Type: GrantFiled: May 19, 2004Date of Patent: April 11, 2006Assignee: The Bingham and Women's Hospital, Inc.Inventors: Arthur O. Tzianabos, Dennis L. Kasper, Andrew B. Onderdonk, Julia Ying Wang
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Publication number: 20040219160Abstract: Methods and products for treating and protecting against asthma and allergic conditions are provided. The methods and products are related to certain naturally occurring and synthetic zwitterionic polymers which are found to induce certain T regulatory (Treg) cells and to exert immunosuppressive effects in vitro and in vivo.Type: ApplicationFiled: March 31, 2004Publication date: November 4, 2004Applicant: The Brigham and Women's Hospital, Inc.Inventors: Arthur O. Tzianabos, Dennis L. Kasper
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Publication number: 20030219413Abstract: The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to novel res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.Type: ApplicationFiled: March 13, 2003Publication date: November 27, 2003Applicant: The Brigham and Women's Hospital, Inc.Inventors: Laurie E. Comstock, Michael J. Coyne, Dennis L. Kasper, Arthur O. Tzianabos, Katja G. Weinacht
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Patent number: 5700787Abstract: Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto also are provided. The products useful in the invention are polysaccharides including a repeat unit having a positively charged free amino group and a negatively charged group. The preferred polysaccharide is B. fragilis capsular polysaccharide A.Type: GrantFiled: July 14, 1995Date of Patent: December 23, 1997Assignee: Brigham & Women's Hospital, Inc.Inventors: Arthur O. Tzianabos, Andrew B. Onderdonk, Dennis L. Kasper
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Patent number: 5679654Abstract: Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto also are provided. The products useful in the invention are polysaccharides including a repeat unit having a positively charged free amino group and a negatively charged group. The preferred polysaccharide is B. fragilis capsular polysaccharide A.Type: GrantFiled: September 2, 1994Date of Patent: October 21, 1997Assignee: Brigham & Women's Hospital, Inc.Inventors: Arthur O. Tzianabos, Andrew B. Onderdonk, Dennis L. Kasper