Abstract: Methods for improving patient recovery after cerebral ischaemia are described. The methods include administering an electrical stimulus to a nerve of the patient innervating opposed leg muscles sufficient to cause isometric contraction of said muscles. The isometric contraction may result in improved or increased cerebral blood flow, and in some embodiments said electrical stimulation may be sufficient to alter electrical activity in the brain.

Abstract: Methods and devices are described for preventing diastolic flow reversal and/or reducing peripheral vascular resistance in a patient. Also described are methods of cosmetic treatment, and methods of promoting delivery of therapeutic agents or contrast agents to bones and related tissues.

Abstract: The invention relates to a method and device for neuromuscular stimulation of one or more muscles, or muscle groups, with one or more beneficial effects selected from increasing arterial, venous and capillary blood flow, increasing flux of interstitial fluid and lymphatic drainage, increasing tissue oxygenation, enhancing heat distribution, enhancing the distribution of pharmaceutical products, and enhancing performance and recovery from exertion in horses.

Abstract: Methods and devices are described for preventing diastolic flow reversal and/or reducing peripheral vascular resistance in a patient. Also described are methods of cosmetic treatment, and methods of promoting delivery of therapeutic agents or contrast agents to bones and related tissues.

Abstract: Methods and devices are described for preventing diastolic flow reversal and/or reducing peripheral vascular resistance in a patient. Also described are methods of cosmetic treatment, and methods of promoting delivery of therapeutic agents or contrast agents to bones and related tissues.

Abstract: Methods and devices are described for preventing diastolic flow reversal and/or reducing peripheral vascular resistance in a patient. Also described are methods of cosmetic treatment, and methods of promoting delivery of therapeutic agents or contrast agents to bones and related tissues.

Abstract: A system and method for securely joining a high melting temperature material and a backing substrate using a mechanical connection includes a backing substrate integrally formed with a material positioned inside a dovetail recess in the high melting temperature material, mechanically fixing the backing substrate to the high melting temperature material without fusion or bonding of the microstructure.

Abstract: Methods and devices are described for preventing diastolic flow reversal and/or reducing peripheral vascular resistance in a patient. Also described are methods of cosmetic treatment, and methods of promoting delivery of therapeutic agents or contrast agents to bones and related tissues.

Abstract: The invention relates to a method and device for neuromuscular stimulation of one or more muscles, or muscle groups, with one or more beneficial effects selected from increasing arterial, venous and capillary blood flow, increasing flux of interstitial fluid and lymphatic drainage, increasing tissue oxygenation, enhancing heat distribution, enhancing the distribution of pharmaceutical products, and enhancing performance and recovery from exertion in horses.

Abstract: A device for identifying appropriate nerve stimulation points on a patient is described, for use with an electrical stimulation device. In a first embodiment, the device includes electrodes located on a flexible substrate, a conductive gel layer overlying the electrodes, and a partially conductive removable cover overlying the gel layer. The device may be operated initially with the cover in place to allow reduced stimulation to identify a suitable nerve stimulation point. The cover may then be removed, and the device operated at the identified point. The cover may include perforations allowing the gel to contact the patient; or may be a sacrificial gel layer.

Abstract: A method and device for increasing microcirculation in the lower limb are described. The device includes a means for immobilising the limb, for example a plaster cast, and an electrical stimulation device, which applies electrical stimulation to opposed leg muscles such that antagonistic and agonistic muscle groups contract near simultaneously, resulting in near isometric contraction. The combination of this contraction and the leg restraint have been found to markedly increase blood circulation and in particular microcirculation in the limb.

Abstract: A device for identifying appropriate nerve stimulation points on a patient is described, for use with an electrical stimulation device. In a first embodiment, the device includes electrodes located on a flexible substrate, a conductive gel layer overlying the electrodes, and a partially conductive removable cover overlying the gel layer. The device may be operated initially with the cover in place to allow reduced stimulation to identify a suitable nerve stimulation point. The cover may then be removed, and the device operated at the identified point. The cover may include perforations allowing the gel to contact the patient; or may be a sacrificial gel layer.

Abstract: Methods and devices are described for preventing diastolic flow reversal and/or reducing peripheral vascular resistance in a patient. Also described are methods of cosmetic treatment, and methods of promoting delivery of therapeutic agents or contrast agents to bones and related tissues.

Abstract: The use of acidified nitrate as an agent to produce local production of nitrate oxide at the skin surface is described in the treatment of peripheral ischaemia and associated conditions. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. A barrier consisting of a membrane allows diffusions of the nitrate ions while preventing direct contact of the skin and acidifying agent. Amongst the many potential applications for the invention is the management of chronic skin wounds, peripheral ischaemia conditions such as Raynaud's phenomenon. Compositions and methods of use for these applications are described.

Abstract: A pharmaceutical dispenser, comprising a liquid formulation comprising nitric oxide, and means for forming a nebulised mist of the liquid formulation. The nebulised mist of the liquid formulation is used primarily in the treatment of respiratory diseases.