Abstract: A caulking gun and cartridge combination is provided with afterflow prevention. The cartridge has a tubular body, a forward dispensing opening at a forward end of the tubular body, and a backwall movably disposed within the tubular body. The caulking gun has a trough for receiving the cartridge, and a piston movable parallel to the trough. A trigger handle is used for pushing the backwall forward within the tubular body and causing a reduction of volume within the chamber in the cartridge. The backwall slides substantially in a contact-less manner within the tubular body, preferably by way of a reduced diameter of the backwall relative the inner diameter of the tubular body, so that it is pushed backwardly when the body retracts radially after actuation. Alternatively, the cartridge body may be prevented from expanding or may even be actively squeezed so that afterflow caused by the volume reduction of the relaxing tube body is safely prevented.

Abstract: Disclosed is the method of determining the effectiveness of an agent for the prevention of pain in a person's joints, comprising the steps ofa) administering to a susceptible subject a quantity of a trigger substance reproducibly effective in producing within a period of not more than ten hours the occurrence of pain in a joint of said subject lasting for at least one week in the absence of treatment,b) administering to said subject having received said quantity of trigger substance a predetermined quantity of the agent whose effectiveness is to be determined,c) measuring the time required for relief of pain in a joint of the subject upon administering said agent, andd) comparing the time required for relief of said pain with and without the administration of said agent. Also disclosed are effective quantities of certain nutrient substances which can reproducibly relieve pain in a joint produced in a susceptible subject by the administration of a trigger substance.

Abstract: Disclosed is the method of determining the effectiveness of an agent for relieving symptoms of the common cold, comprising the steps ofa) exposing a susceptible subject to vapors of a trigger substance reproducibly effective in producing within a period of 30 minutes a running nose lasting for at least 6 hours in the absence of treatment,b) administering to said subject having been exposed to a trigger substance a predetermined quantity of the agent whose effectiveness is to be determined,c) measuring the time required for the running nose to be abated, andd) comparing the time required for the running nose to be abated with and without the administration of said agent.Also disclosed are effective quantities of certain nutrient substances which can reproducibly relieve symptoms of the common cold produced in a susceptible subject by the administration of a trigger substance.

Abstract: Disclosed is the method of determining the effectiveness of an agent for the prevention of facial pimples or acne, comprising the steps ofa) administering to a susceptible subject a quantity of a trigger substance reproducibly effective in producing within a period of four hours the appearance of at least two pimples on the face of the subject lasting for at least eight hours in the absence of treatment,b) administering to said subject having received said quantity of trigger substance a predetermined quantity of the agent whose effectiveness is to be determined,c) measuring the number of pimples on the face of the subject upon administering said agent, andd) comparing the number of pimples with and without the administration of said agent.Also disclosed are effective quantities of certain nutrient substances which can reproducibly relieve pimples produced in a susceptible subject by the administration of a trigger substance.

Abstract: A caulking gun and cartridge combination is provided with afterflow prevention. The cartridge has a tubular body, a forward dispensing opening at a forward end of the tubular body, and a backwall movably disposed within the tubular body. The caulking gun has a trough for receiving the cartridge, and a piston movable parallel to the trough. A trigger handle is used for pushing the backwall forward within the tubular body and causing a reduction of volume within the chamber in the cartridge. The backwall slides substantially in a contact-less manner within the tubular body, preferably by way of a reduced diameter of the backwall relative the inner diameter of the tubular body, so that it is pushed backwardly when the body retracts radially after actuation. Alternatively, the cartridge body may be prevented from expanding or may even be actively squeezed so that afterflow caused by the volume reduction of the relaxing tube body is safely prevented.