Abstract: Embodiments of the invention provide a chamber for a bioreactor, the chamber having a fluid inlet aperture and a fluid outlet aperture disposed at respective different locations of a wall of the chamber, with respect to a normal upright orientation of the chamber the chamber being provided with an upper wall portion defining an upper boundary of the chamber. The upper wall portion has an internal surface having a first portion that is vertically displaced with respect to a second portion. The internal surface of the upper wall portion is arranged to promote expulsion of trapped gas bubbles through the outlet aperture, the first and second portions of the upper wall portion each comprising a sloped portion.

Abstract: Embodiments of the invention provide a bioreactor chamber assembly comprising: a bioreactor chamber comprising first and second portions arranged to be coupled to one another thereby to provide a liquid-tight seal therebetween; a pair of clamp members; and a pair of resilient loop elements, wherein the clamp members are arranged to sandwich the chamber between the clamp members and the loop elements are arranged to apply a force between the clamp members to urge the first and second portions together.

Abstract: A bioreactor (1) for subjecting a cell culture (3) to a hydrodynamic pressure stimulus is described. This hydrodynamic pressure is generated inside at least one culture chamber (2) by means of variation of the mean distance, with a controlled speed, of a surface relative to the surface on which the culture (3) is positioned and between which the culture medium (5) is free to flow.

Abstract: Embodiments of the invention provide a bioreactor chamber assembly comprising: a bioreactor chamber comprising first and second portions arranged to be coupled to one another thereby to provide a liquid-tight seal therebetween; a pair of clamp members; and a pair of resilient loop elements, wherein the clamp members are arranged to sandwich the chamber between the clamp members and the loop elements are arranged to apply a force between the clamp members to urge the first and second portions together.

Abstract: Embodiments of the invention provide a chamber for a bioreactor, the chamber having a fluid inlet aperture and a fluid outlet aperture disposed at respective different locations of a wall of the chamber, with respect to a normal upright orientation of the chamber the chamber being provided with an upper wall portion defining an upper boundary of the chamber. The upper wall portion has an internal surface having a first portion that is vertically displaced with respect to a second portion. The internal surface of the upper wall portion is arranged to promote expulsion of trapped gas bubbles through the outlet aperture, the first and second portions of the upper wall portion each comprising a sloped portion.

Abstract: A bioreactor device for studying the effects of physical, chemical, mechanical and electromagnetic stimuli on the cellular activity. In particular, the device uses a sensorized premixing chamber (1), a culture chamber (2) for observing the development of the cells by a microscope (40). Output signals are transmitted to a control unit for amplifying and filtering the signals (50), which transmits the treated signals to a computer (52). To another control unit (51) actuating electrovalves (20), (21) and (22) are connected that adjust the introduction of gas in the premixing chamber. The culture medium is drawn from the premixing chamber (1) through a duct (4) and its flow is adjusted by a peristaltic pump (30). The culture medium crosses then the culture chamber (2) and continues its path in a duct (3), returning again in the premixing chamber (1). At the outlet of the culture chamber (2) the duct has a sample point (23) for picking up an amount of culture medium to analyze.

Abstract: A bioreactor device for studying the effects of physical, chemical, mechanical and electromagnetic stimuli on the cellular activity. In particular, the device uses a sensorized premixing chamber (1), a culture chamber (2) for observing the development of the cells by a microscope (40). Output signals are transmitted to a control unit for amplifying and filtering the signals (50), which transmits the treated signals to a computer (52). To another control unit (51) actuating electrovalves (20), (21) and (22) are connected that adjust the introduction of gas in the premixing chamber. The culture medium is drawn from the premixing chamber (1) through a duct (4) and its flow is adjusted by a peristaltic pump (30). The culture medium crosses then the culture chamber (2) and continues its path in a duct (3), returning again in the premixing chamber (1). At the outlet of the culture chamber (2) the duct has a sample point (23) for picking up an amount of culture medium to analyse.