Abstract: This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) of Neisseria meningitidis in solutions containing fully synthetic variants of the GM3 ganglioside.

Abstract: A check valve may include: a check seat defining a flow path; a clapper assembly hingedly connected to the check seat and configured to obstruct the flow path, including: a clapper and a seal retainer detachably mounted to the clapper; a first extension extending from the clapper assembly in an upstream direction and having a roller; a cam arm rotatable relative to the clapper assembly and configured to engage with the roller; and a torsion spring operatively connected to the cam arm so as to apply a biasing force to the cam arm in the upstream direction. The biasing force may be imparted to the clapper assembly via the cam arm and roller, so that the clapper assembly obstructs the flow path.

Abstract: A spring stop arrangement for a check valve may include: a check seat defining a flow path; a clapper assembly connected to the check seat and configured to obstruct the flow path, the clapper assembly including: a clapper; and a seal retainer detachably mounted to the clapper; a cam arm connected to the check seat, the cam arm including a stopper; and a torsion spring operatively connected to the cam arm so as to apply a biasing force to the cam arm against the direction of fluid flow. When the seal retainer is dismounted from the clapper, the stopper may be configured to contact the check seat so as to prevent rotation of the cam arm.

Abstract: A multi position single direction sleeve valve includes a housing having a port therein, and a sleeve movable within the housing, the sleeve having a first portion including a radially extending opening therein and a second portion, the second portion being releasably attached to the first portion. A fracture system, including multi position single direction sleeve valve, and a bottom hole assembly having a profile engagable with the sleeve to shift a position of the sleeve relative to the housing, the bottom hole assembly having a debris barrier. A method including running the multi position single direction sleeve, including moving the sleeve from a closed position to an open position, and moving the sleeve from the open position to a closed position.

Abstract: The present invention relates to a cell, wherein the cell is modified to: reduce O-GalNAc galactosylation activity in the cell by reduction of functional COSMC molecular chaperone in the cell and/or by reduction of functional T-synthase in the cell; and overexpress ?1,4-galactosyltransferase in the cell; and associated methods, kits and uses.

Abstract: A method of conducting a plurality of downhole operations with a completion system, the method including performing a treatment through a port in a first sleeve assembly in a first stage of the completion system, using an object to slide a first sleeve in a second sleeve assembly, located uphole of the first sleeve assembly, in a second stage of the completion system to reveal a port, and then closing the port in the first sleeve assembly in the first stage using the object, performing a treatment through the port in the second sleeve assembly, closing the port in the second sleeve assembly, and opening at least one of the ports in the first sleeve assembly and the second sleeve assembly and producing fluids through the at least one of the ports. A completion system includes the sleeve assemblies and object for performing the method.

Abstract: A multi-stage object drop frac assembly that includes a fracture subassembly is configured for disposal in a well zone. The assembly includes a plurality of filtration media stages configured for disposal in the same well zone. A plurality of valves, one of the plurality of valves being associated with each of the plurality of filtration media stages is a part of the assembly and the plurality of valves are openable simultaneously in response to the same event.

Abstract: A multi-stage object drop frac assembly including a fracture subassembly configured for disposal in a well zone, a plurality of filtration media stages configured for disposal in the same well zone, and a plurality of valves, one of the plurality of valves being associated with each of the plurality of filtration media stages the plurality of valves openable simultaneously in response to a same event.

Abstract: A biodegradable, non-pressure compression leg wrap for cattle suffering lameness from for example digital dermatitis with disintegration time controlled by the ratio of polyvinyl alcohol to copolymer starch or cellulose in the wrap composition.

Abstract: The present invention provides an apparatus and a method in a radio communications system. The apparatus in a radio communications system comprises an estimation unit and a statistics collection unit. The estimation unit is used for estimating a signal receiving strength of each of multiple transmission positions, compared with a signal transmission strength of each of one or more possible transmission positions of a first-type node of a to-be-test communications system on a transmission resource block. The statistics collection unit is used for collecting, according the estimation result, statistics on power space distribution of the first-type node of the to-be-tested communications system.

Abstract: The present invention provides an apparatus and a method in a radio communications system. The apparatus in a radio communications system comprises an estimation unit and a statistics collection unit. The estimation unit is used for estimating a signal receiving strength of each of multiple transmission positions, compared with a signal transmission strength of each of one or more possible transmission positions of a first-type node of a to-be-test communications system on a transmission resource block. The statistics collection unit is used for collecting, according the estimation result, statistics on power space distribution of the first-type node of the to-be-tested communications system.

Abstract: An apparatus and a method in a radio communications system. The apparatus in the radio communications system includes an estimation unit and a statistics collection unit. The estimation unit is used for estimating a signal receiving strength of each of multiple transmission positions, compared with a signal transmission strength of each of one or more possible transmission positions of a first-type node of a to-be-test communications system on a transmission resource block. The statistics collection unit is used for collecting, according the estimation result, statistics on power space distribution of the first-type node of the to-be-tested communications system.

Abstract: An apparatus and a method in a radio communications system. The apparatus in the radio communications system includes an estimation unit and a statistics collection unit. The estimation unit is used for estimating a signal receiving strength of each of multiple transmission positions, compared with a signal transmission strength of each of one or more possible transmission positions of a first-type node of a to-be-test communications system on a transmission resource block. The statistics collection unit is used for collecting, according the estimation result, statistics on power space distribution of the first-type node of the to-be-tested communications system.

Abstract: This Application for a patent of invention refers to a Machine for the assembly or production of sandwich-type panels for use in the construction industry which would have no rusting problems and use support chair connectors with metal closures.

Abstract: A self-contained drafting instrument adapted for rapid measurement of diagrams or drawings on a surface. The instrument utilizes an internal movement detection mechanism, an electronics processing system, and a display screen capable of graphical representation. The movement detection mechanism measures both orthogonal components of movement and the display screen provides a scale that electronically scrolls as the instrument moves or by manually pressing a key on a keyboard. The drafting instrument can be constructed in a number of orientations including a ruler, drafting triangle, protractor, or T-square.