Patents by Inventor Ashley Edward Fenwick
Ashley Edward Fenwick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9549929Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.Type: GrantFiled: May 18, 2015Date of Patent: January 24, 2017Assignee: Pfizer Inc.Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez, Mihir D. Parikh
-
Patent number: 9545405Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.Type: GrantFiled: April 21, 2015Date of Patent: January 17, 2017Assignee: Pfizer Inc.Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez, Mihir D. Parikh
-
Publication number: 20150246048Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.Type: ApplicationFiled: May 18, 2015Publication date: September 3, 2015Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez, Mihir D. Parikh
-
Publication number: 20150225408Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.Type: ApplicationFiled: April 21, 2015Publication date: August 13, 2015Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez, Mihir D. Parikh
-
Patent number: 9035074Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.Type: GrantFiled: February 19, 2014Date of Patent: May 19, 2015Assignee: Pfizer Inc.Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez, Mihir D. Parikh
-
Publication number: 20140243312Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.Type: ApplicationFiled: February 19, 2014Publication date: August 28, 2014Applicant: Pfizer Inc.Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez
-
Publication number: 20080267942Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof are agonists at the beta-2 adrenoceptor. They are useful as feed additives for livestock animals.Type: ApplicationFiled: April 11, 2008Publication date: October 30, 2008Applicant: Pfizer LimitedInventors: Jessica Boyle, Ashley Edward Fenwick, David Morris Gethin, Catherine Frances McCusker
-
Publication number: 20080161288Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof are agonists at the beta-2 adrenoceptor. They are useful as feed additives for livestock animals.Type: ApplicationFiled: November 21, 2007Publication date: July 3, 2008Inventors: Jessica Boyle, Ashley Edward Fenwick, David Morris Gethin, Catherine Frances McCusker
-
Patent number: 7115616Abstract: Pyrimidinone compounds of formula (10 are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.Type: GrantFiled: February 11, 2004Date of Patent: October 3, 2006Assignee: SmithKline Beecham PlcInventors: Ashley Edward Fenwick, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
-
Publication number: 20040167142Abstract: Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.Type: ApplicationFiled: February 11, 2004Publication date: August 26, 2004Applicant: SmithKline Beecham p.l.c.Inventors: Ashley Edward Fenwick, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
-
Patent number: 6719520Abstract: A method for the treatment of conditions associated with a need for inhibition of GSK-3, such as diabetes, dementias such as Alzheimer's disease and manic depression which method comprises the administration of a pharmaceutically effective, non-toxic amount of a compound of formula (I): or a pharmaceutically acceptable derivative thereof, wherein: R is hydrogen, alkyl, aryl, or aralkyl; R1 is hydrogen, alkyl, aralkyl, hydroxyalkyl or alkoxyalkyl; R2 is substituted or unsubstituted aryl or substituted or unsubstituted heterocyclyl; R3 is hydrogen, substituted or unsubstituted alkyl, cycloalkyl, alkoxyalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl or aralkyl wherein the aryl moiety is substituted or unsubstituted; or, R1 and R3 together with the nitrogen to which they are attached form a single or fused, optionally substituted, saturated or unsaturated heterocylic ring; to a human or non-human mammal in need thereof, and compounds of formula I.Type: GrantFiled: May 28, 2003Date of Patent: April 13, 2004Assignee: SmithKline Beecham CorporationInventors: Matthew Paul Coghlan, Ashley Edward Fenwick, David Haigh, Julie Caroline Holder, Robert John Ife, Alastair David Reith, David Glynn Smith, Robert William Ward
-
Publication number: 20040010031Abstract: A method for the treatment of conditions associated with a need for inhibition of GSK-3, such as diabetes, dementias such as Alzheimer's disease and manic depression which method comprises the administration of a pharmaceutically effective, non-toxic amount of a compound of formula (I): 1Type: ApplicationFiled: May 28, 2003Publication date: January 15, 2004Applicant: SmithKline Beecham p.l.c.Inventors: Matthew Paul Coghlan, Ashley Edward Fenwick, David Haigh, Julie Caroline Holder, Robert John Ife, Alastair David Reith, David Glynn Smith, Robert William Ward
-
Publication number: 20030207876Abstract: Compounds of formula I, 1Type: ApplicationFiled: April 8, 2002Publication date: November 6, 2003Inventors: Bernard Joseph Banks, Douglas James Critcher, Ashley Edward Fenwick, David Morris Gethin, Stephen Paul Gibson
-
Patent number: 6566373Abstract: The invention relates to 3-hydroxy-and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hydroxy-or 3-keto-moiety is bonded to a tetrahydrothiophene, tetrahydrothiopyran, tetrahydrofuran or tetrahydropyran ring.Type: GrantFiled: July 30, 2001Date of Patent: May 20, 2003Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.Inventors: Andrew D Gribble, Ashley Edward Fenwick, Robert W Marquis, Daniel F Veber, Jason Witherington
-
Publication number: 20020025948Abstract: Compounds of formula I, 1Type: ApplicationFiled: June 18, 2001Publication date: February 28, 2002Inventors: Bernard Joseph Banks, Douglas James Critcher, Ashley Edward Fenwick, David Morris Gethin, Stephen Paul Gibson
-
Publication number: 20020013360Abstract: The invention relates to 3-hydroxy-and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hydroxy-or 3-keto-moiety is bonded to a tetrahydrothiophene, tetrahydrothiopyran, tetrahydrofuran or tetrahydropyran ring.Type: ApplicationFiled: July 30, 2001Publication date: January 31, 2002Applicant: SmithKline Beecham CorporationInventors: Andrew D. Gribble, Ashley Edward Fenwick, Robert W. Marquis, Daniel F. Veber, Jason Witherington
-
Patent number: 5733882Abstract: The present invention provides compounds, more particularly dipeptide analogs, which bind to retroviral proteases. These compounds are inhibitors of retroviral proteases and are useful for treating diseases related to infection by retroviruses.Type: GrantFiled: February 28, 1995Date of Patent: March 31, 1998Assignee: SmithKline Beecham CorporationInventors: Thomas Joseph Carr, Peter Lawrence DeMarsh, Geoffrey Bainbridge Dreyer, Ashley Edward Fenwick