Patents by Inventor Ashok Kumar Gangopadhyay
Ashok Kumar Gangopadhyay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10023885Abstract: The present invention provides an improved process for the preparation of a compound of formula (I), which comprises the steps of: formula (I), (a) reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) optionally in presence of salts of weak acid and weak base or weak base in a suitable solvent to get 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV); (b) reacting 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV) with a suitable cyanide source in water or in an organic solvent or mixture thereof to get 2-isobutylsuccinonitrile of formula (V); (c) obtaining optionally 2-isobutylsuccinonitrile of formula (V) by reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) in presence of suitable cyanide source in water or in an organic solvent or mixture thereof in single step; (d) converting 2-isobutylsuccinonitrile of formula (V) to racemic 3-cyano-5-methyl-hexanoic acid or salt thereof of formula (VI) with a genetically modified nitrilasType: GrantFiled: November 4, 2013Date of Patent: July 17, 2018Assignee: Hikal LimitedInventors: Swapnil Surendra Mohile, Swapnil Gulabrao Yerande, Sarika Madhukarrao Lunge, Rameshkumar Maghabhai Patel, Shivaji Balbhim Gugale, Rajesh Mataprasad Thakur, Ramesh Ananda Mokal, Ashok Kumar Gangopadhyay, Peter David Nightingale
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Publication number: 20150344919Abstract: The present invention provides an improved process for the preparation of a compound of formula (I), which comprises the steps of: formula (I), (a) reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) optionally in presence of salts of weak acid and weak base or weak base in a suitable solvent to get 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV); (b) reacting 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV) with a suitable cyanide source in water or in an organic solvent or mixture thereof to get 2-isobutylsuccinonitrile of formula (V); (c) obtaining optionally 2-isobutylsuccinonitrile of formula (V) by reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) in presence of suitable cyanide source in water or in an organic solvent or mixture thereof in single step; (d) converting 2-isobutylsuccinonitrile of formula pa (V) to racemic 3-cyano-5-methyl-hexanoic acid or salt thereof of formula (VI) with a genetically modified nitriType: ApplicationFiled: November 4, 2013Publication date: December 3, 2015Inventors: Swapnil Surendra Mohile, Swapnil Gulabrao Yerande, Sarika Madhukarrao Lunge, Rameshkumar Maghabhai Patel, Shivaji Balbhim Gugale, Rajesh Mataprasad Thakur, Ramesh Ananda Mokal, Ashok Kumar Gangopadhyay, Peter David Nightingale
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Patent number: 8835428Abstract: The present invention relates to isoxazole, thiazole and oxidiazole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, in particular to the use of these compounds in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1.Type: GrantFiled: February 24, 2011Date of Patent: September 16, 2014Assignee: Piramal Enterprises LimitedInventors: Ashok Kumar Gangopadhyay, Kishorkumar Shivajirao Kadam, Ravindra Dnyandev Jadhav, Hitesh Mistry, Rajiv Sharma
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Patent number: 8206756Abstract: This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor- (TNF-?) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions.Type: GrantFiled: July 9, 2009Date of Patent: June 26, 2012Assignee: Piramal Life Sciences LimitedInventors: Vijay Chauhan, Ashish Suthar, Dhananjay Sapre, Swati Bal-Tembe, Ashok Kumar Gangopadhyay, Asha Kulkarni-Almeida, Sapna Hasit Parikh, Ravindra Dattatraya Gupte, Nilesh Madhukar Dagia, Somesh Sharma, Shruta Sudheer Dadarkar, Mahesh Gundaji Jadhav, Aditi Amol Tannu
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Publication number: 20110196002Abstract: The present invention relates to isoxazole, thiazole and oxidiazole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, in particular to the use of these compounds in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1.Type: ApplicationFiled: February 24, 2011Publication date: August 11, 2011Inventors: Ashok Kumar GANGOPADHYAY, Kishorkumar Shivajirao Kadam, Ravindra Dnyandev Jadhav, Hitesh Mistry, Rajiv Sharma
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Patent number: 7964628Abstract: This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.Type: GrantFiled: June 8, 2010Date of Patent: June 21, 2011Assignee: Piramal Life Sciences LimitedInventors: Bansi Lal, Ashok Kumar Gangopadhyay, Vadlamudi V. S. V. Rao, Ravindra Dattatraya Gupte, Gopal Vishnu Gole, Asha Kulkarni-Almeida, Sridevi Krishnan, Radha Bhaskar Panicker, Eleanor Pinto De Souza
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Publication number: 20100256161Abstract: This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.Type: ApplicationFiled: June 8, 2010Publication date: October 7, 2010Applicant: Piramal Life Sciences LimitedInventors: Bansi Lal, Ashok Kumar Gangopadhyay, Vadlamudi V.S.V Rao, Ravindra Dattatraya Gupte, Radha Bhaskar Panicker, Eleanor Pinto De Souza, Gopal Vishnu Gole, Asha Kulkarni-Almeida, Sridevi Krishnan
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Patent number: 7759387Abstract: This invention relates to novel fused bicyclic compounds of the general formula (I): wherein the symbols are defined herein, to pharmaceutical compositions containing the compounds, processes for preparing the compounds, and to methods of using the compounds, alone or in combination with other therapeutic agents. The compounds are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, and are therefore useful for the inhibition of platelet aggregation, and for the treatment of thrombotic diseases and other diseases.Type: GrantFiled: September 30, 2004Date of Patent: July 20, 2010Assignee: Piramal Life Sciences LimitedInventors: Bansi Lal, Ashok Kumar Gangopadhyay, Vadlamudi V. S. V. Rao, Ravindra Dattatraya Gupte, Gopal Vishnu Gole, Asha Kulkarni-Almeida, Sridevi Krishnan, Radha Bhaskar Panicker, Eleanor Pinto De Souza
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Publication number: 20090318465Abstract: The present invention relates to a method for identifying compounds that act as insulin-sensitizers. The method can include screening of test compounds in two assays of insulin sensitivity. This method can identify lead compounds for the treatment of disorders caused by insulin resistance to glucose uptake. This invention also includes methods for treating insulin resistance and related disorders.Type: ApplicationFiled: September 20, 2007Publication date: December 24, 2009Inventors: Rosalind Adaikalasamy Marita, Somesh Sharma, Jessy Anthony, Kelkar Aditya, Sujit Kaur Bhumra, Aditee Ghate, Kumar Venkata Subrahman Nemmani, Nabajyoti Deka, Ashok Kumar Gangopadhyay
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Patent number: 7635494Abstract: This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor- (TNF-?) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions.Type: GrantFiled: March 28, 2008Date of Patent: December 22, 2009Assignee: Piramal Life Sciences LimitedInventors: Vijay Chauhan, Ashish Suthar, Dhananjay Sapre, Swati Bal-Tembe, Ashok Kumar Gangopadhyay, Asha Kulkarni-Almeida, Sapna Hasit Parikh, Ravindra Dattatraya Gupte, Nilesh Madhukar Dagia, Somesh Sharma, Shruta Sudheer Dadarkar, Mahesh Gundaji Jadhav, Aditi Amol Tannu
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Publication number: 20090269427Abstract: This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor- (TNF-?) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions.Type: ApplicationFiled: July 9, 2009Publication date: October 29, 2009Applicant: Piramal Life Sciences LimitedInventors: Vijay CHAUHAN, Ashish SUTHAR, Dhananjay SAPRE, Swati BAL-TEMBE, Ashok Kumar GANGOPADHYAY, Asha KULKARNI-ALMEIDA, Sapna Hasit PARIKH, Ravindra Dattatraya GUPTE, Nilesh Madhukar DAGIA, Somesh SHARMA, Shruta Sudheer DADARKAR, Mahesh Gundaji JADHAV, Aditi Amol TANNU
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Publication number: 20080254157Abstract: This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7-Hydroxy-4,11(13)-eudesmadien-12,6-olide) (compound 1), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (compound 1) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor- (TNF-?) and interleukin (IL-1, IL-6, IL-8) inhibitory activity of the said compositions.Type: ApplicationFiled: March 28, 2008Publication date: October 16, 2008Applicant: PIRAMAL LIFE SCIENCES LIMITEDInventors: Vijay Chauhan, Ashish Suthar, Dhananjay Sapre, Swati Bal-Tembe, Ashok Kumar Gangopadhyay, Asha Kulkarni-Almeida, Sapna Hasit Parikh, Ravindra Dattatraya Gupte, Nilesh Madhukar Dagia, Somesh Sharma, Shruta Sudheer Dadarkar, Mahesh Gundaji Jadhav, Aditi Amol Tannu