Abstract: The present invention relates to a method of preparing a nanoparticle comprising at least one cell-penetrating peptide (CPP) and a cargo molecule, said method comprising the steps: preparing a CPP solution comprising a CPP, a dry alcohol; and 1-50% (v/v) of an aprotic solvent; diluting the CPP solution in water to a concentration of 2 to 500 ?M, and adding the cargo molecule to the CPP solution to obtain a CPP:CM mixture; whereby nanoparticles comprising CPP and cargo molecule are formed. The invention further relates to a nanoparticle obtained or obtainable by the method, as well as pharmaceutical compositions comprising such nanoparticles.

Abstract: The invention relates generally to methods for the diagnosis and/or prognosis of an amyloid-associated disease, methods of treating an amyloid-associated disease, and methods of identifying an agent for the treatment of an amyloid-associated disease, as well as related uses and kits of parts

Abstract: The present invention relates to a method for predicting or designing, detecting, and/or verifying a novel cell-penetrating peptide (CPP) and to a method for using said new CPP and/or a novel usage of a known CPP for an improved cellular uptake of a cellular effector, coupled to said CPP. Furthermore, the present invention also relates to a method for predicting or designing, detecting and/or verifying a novel cell-penetrating peptide (CPP) that mimics cellular effector activity and/or inhibits cellular effector activity. The present invention additionally relates to the use of said CPP for treating and/or preventing a medical condition and to the use of said CPP for the manufacture of a pharmaceutical composition for treating a medical condition.