Abstract: The present inventors found cyclic peptide compounds that interact with Ras, and pharmaceutical compositions containing the cyclic peptide compounds or salts thereof, or solvates thereof.

Abstract: This nonaqueous electrolyte secondary battery comprises: an electrode body which is obtained by winding a positive electrode and a negative electrode, with a separator being interposed therebetween; a nonaqueous electrolyte; and an outer case for housing the electrode body and the nonaqueous electrolyte. The negative electrode comprises a first negative electrode active material and a second negative electrode active material that has a greater expansion coefficient than the first negative electrode active material during charging; and if the proportion of the mass of the second negative electrode active material with respect to the total mass of the first negative electrode active material and the second negative electrode active material is defined as the second negative electrode active material ratio, the second negative electrode active material ratio at the outer winding end is smaller than the second negative electrode active material ratio at the inner winding end.

Abstract: A method for producing a hydrogenated polymer composition including a hydrogenated conjugated diene modified polymer that has a boron-containing functional group, the method including: (1) anionically polymerizing a monomer including a conjugated diene in the presence of a reactive metal or reactive metal compound capable of causing anionic polymerization to produce a reactive terminal polymer (Z); (2) reacting the reactive terminal polymer (Z) obtained in (1) with a boric acid compound that has at least two partial structures represented by B—O—R (I), and in which at least one R bonded to an oxygen atom in the partial structure (I) has a Taft's steric parameter Es value of ?0.30 or less to obtain an unhydrogenated conjugated diene modified polymer having a boron-containing functional group; and (3) hydrogenating at least some of carbon-carbon double bonds contained in conjugated diene units included in the unhydrogenated conjugated diene modified polymer obtained in (2).

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: This battery storage tray is provided with: a bottom plate which supports a plurality of batteries; a side wall which extends from the outer peripheral part of an upper surface of the bottom plate in the thickness direction of the bottom plate so as to surround a stage surface for the plurality of batteries in the upper surface, thereby defining a battery storage space, in which the plurality of batteries are contained, together with the bottom plate; and a plate-like permanent magnet which is affixed to at least a part of a bottom surface of the bottom plate.

Abstract: A state determination device determines the state of a drive mechanism configured to operate while holding a substrate in a substrate processing apparatus. The state determination part includes: an acquisition part configured to acquire operation data for the drive mechanism; a model generation part configured to generate a monitoring model for the drive mechanism by executing machine learning using an auto-encoder based on normal operation data that is derived from the operation data acquired by the acquisition part when the drive mechanism is operating normally; and a first determination part configured to determine the state of the drive mechanism based on first output data obtained by inputting, to the monitoring model, evaluation data that is derived from the operation data acquired by the acquisition part when the drive mechanism is being evaluated.

Abstract: In some embodiments, the present disclosure relates to mutated tRNAs in which the first letter of the anticodon has been substituted to lysidine or agmatidine, and translation systems containing the mutated tRNAs. In a specific embodiment, the present disclosure provides mutated tRNAs capable of selectively translating codon NNA. In another embodiment, the present disclosure provides translation systems capable of translating two or three types of amino acids from a single codon box. In still another embodiment, the present disclosure provides novel methods for synthesizing lysidine diphosphate, agmatidine diphosphate, and derivatives thereof.

Abstract: The present invention provides modified aminoacyl-tRNA synthetases (ARSs) having increased reactivity with N-methyl amino acids compared to natural aminoacyl-tRNA synthetases. The modified aminoacyl-tRNA synthetases according to the present invention can aminoacylate tRNAs with their corresponding N-methyl-substituted amino acids such as N-methyl-phenylalanine, N-methyl-valine, N-methyl-serine, N-methyl-threonine, N-methyl-tryptophan and N-methyl-leucine more efficiently than natural aminoacyl-tRNA synthetases. The present invention enables a more efficient production of polypeptides containing N-methyl amino acids.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: The present invention provides modified aminoacyl-tRNA synthetases (ARSs) having increased reactivity with N-methyl amino acids compared to natural aminoacyl-tRNA synthetases. The modified aminoacyl-tRNA synthetases according to the present invention can aminoacylate tRNAs with their corresponding N-methyl-substituted amino acids such as N-methyl-phenylalanine, N-methyl-valine, N-methyl-serine, N-methyl-threonine, N-methyl-tryptophan, and N-methyl-leucine more efficiently than natural aminoacyl-tRNA synthetases. The present invention enables a more efficient production of polypeptides containing N-methyl amino acids.

Abstract: An objective of the present invention is to provide methods of synthesizing peptides containing structurally diverse amino acids using cell-free translation systems, which can accomplish excellent translational efficiency as compared to conventional techniques (the conventional techniques being methods which involve preparing aminoacyl-tRNAs which do not have protecting groups outside the translation systems without using ARS, and then adding the prepared aminoacyl-tRNAs into translation systems). In the present invention, it was found that amino acid-containing peptides can be synthesized efficiently by protecting an amino acid linked to tRNA with an appropriate protecting group, and then performing the step of deprotecting the protecting group of the amino acid linked to tRNA and the step of peptide translation from a template nucleic acid in a cell-free translation system in parallel.

Abstract: When the initiation suppression method was used for translation of a peptide having at its N terminus an amino acid residue carrying a thiol group near its amino group with specific protecting groups being introduced to the thiol group and the amino group, it was found that not only the probability of initiation of amino acid translation reaction was improved, but also production of cleaved peptides was suppressed and translation efficiency and purity were improved. Furthermore, it was found that it is possible to efficiently promote the cyclization reaction of the peptide through amide bond formation. Based on these findings, the inventors discovered novel methods for preparing complexes between nucleic acids and peptides containing various unnatural amino acids and having an amide bond-mediated cyclized portion.

Abstract: An image forming apparatus includes an image carrier, a developer carrier disposed so as to face the image carrier, a transfer body disposed so as to face the image carrier, and a contact-separation mechanism. The contact-separation mechanism brings the developer carrier and the image carrier into contact with each other and separates the developer carrier and the image carrier from each other, and brings the image carrier and the transfer body into contact with each other and separates the image carrier and the transfer body from each other.

Abstract: An image forming apparatus includes an image carrier, a developer carrier disposed so as to face the image carrier, a transfer body disposed so as to face the image carrier, and a contact-separation mechanism. The contact-separation mechanism brings the developer carrier and the image carrier into contact with each other and separates the developer carrier and the image carrier from each other, and brings the image carrier and the transfer body into contact with each other and separates the image carrier and the transfer body from each other.

Abstract: The present invention provides modified aminoacyl-tRNA synthetases (ARSs) having increased reactivity with N-methyl amino acids compared to natural aminoacyl-tRNA synthetases. The modified aminoacyl-tRNA synthetases according to the present invention can aminoacylate tRNAs with their corresponding N-methyl-substituted amino acids such as N-methyl-phenylalanine, N-methyl-valine, N-methyl-serine, N-methyl-threonine, N-methyl-tryptophan, and N-methyl-leucine more efficiently than natural aminoacyl-tRNA synthetases. The present invention enables a more efficient production of polypeptides containing N-methyl amino acids.

Abstract: It is an object to make it possible to burn and remove particulate matter without generating runaway even if the particulate matter is excessively accumulated at the time of regeneration of an exhaust gas purification device. A common rail engine and the exhaust gas purification device placed in an exhaust gas path of the engine are provided. A plurality of regeneration controls for burning and removing the particulate matter accumulated in the exhaust gas purification device can be executed. The plurality of regeneration controls include at least non-operation regeneration control for raising exhaust gas temperature by combining post injection (E) and predetermined high speed rotation speed, and recovery regeneration control which can be executed when the non-operation regeneration control fails. In the non-operation regeneration control and the recovery regeneration control, the engine is driven exclusively for burning and removing the particulate matter.

Abstract: An exhaust gas purification system comprises an exhaust gas purification device which is arranged in an exhaust gas route of an engine, renewing devices for burning and removing a particulate matter within the exhaust gas purification device, renewal advance notifying means which is actuated in the case that a clogged state of the exhaust gas purification device becomes equal to or more than a prescribed level, and renewal informing means which informs of a fact that the renewing devices are under operation. The renewal advance notifying means is actuated before actuating the renewing devices.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: An exhaust gas purification system comprises an exhaust gas purification device which is arranged in an exhaust gas route of an engine, renewing devices, for burning and removing a particulate matter within the exhaust gas purification device, renewal advance notifying means which is actuated in the case that a clogged state of the exhaust gas purification device becomes equal to or more than a prescribed level, and renewal informing means which informs of a fact that the renewing devices are under operation. The renewal advance notifying means is actuated before actuating the renewing devices.

Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.