Abstract: A propenamide derivative of the formula (I) having, as an essential structural unit, an adhesive peptide represented by the formula (II) in the side chain or salts thereof:Formula (I): R.sup.1 R.sup.2 C.dbd.CR.sup.3 --CO--[NH]--Formula (II): --[R.sup.4 ]--[CO]--([X]-Arg-Gly-Asp-[Y]).sub.n -[Z]--[R.sup.5 ]--wherein R.sup.1 and R.sup.2 each represents a hydrogen atom or a carboxyl group and R.sup.3 represents a hydrogen or halogen atom, methyl, ethyl or carboxymethyl group; X and Y each represents an amino acid residue selected from the group consisting of Ser, Gly, Val, Asn and Pro or a peptide residue consisting of two or more of the amino acids; z represents --O-- or --NH--; one of R.sup.4 and R.sup.

Abstract: There are disclosed amino acid derivatives represented by the following general formula (I): ##STR1## wherein L.sup.1 and L.sup.2 represent an amino acid residue etc., A.sup.1 and A.sup.3 represent C.dbd.O, A.sup.2 represents an alkylene group etc., m and n represent an integer of 1 to 5, V represents --NHC(.dbd.NH)NH.sub.2 etc., W represents --COOH etc., R.sup.1 and R.sup.2 represent hydrogen atom, alkyl group etc., R.sup.3 and R.sup.4 represent hydrogen etc. and X and Y represent --NH-- or --O-- and pharmaceutically acceptable salts thereof and agents for inhibiting tumor matastasis containing the compounds, and the amino acid derivatives exhibit high activity for inhibiting tumor metastasis and weak platelet aggregation inhibition activity and weak anticoagulation activity.

Abstract: A peptide derivative containing 1 to 20 units of peptide unit represented by the following general formula [I] or a pharmaceutically acceptable salt thereof;[Z]--Arg--X--Asp--[Y] [I]wherein Arg represents L- or D-arginine residue, Asp represents L-aspartic acid residue, X represents L- or D-leucine, D-isoleucine, L- or D-norleucine, L- or D-phenylalanine, D-phenylglycine or D-alanine residue, and [Z] and [Y] each represents an amino acid or a peptide residue, which may be present or absent, selected from glycine, L-serine, L-threonine, L- and D-aspartic acid, L-alanine, L- and D-glutamic acid, L-proline residues and a peptide residue constituted by the foregoing amino acid residues, and a pharmaceutical composition comprising the peptide derivative. The composition of the present invention is useful as an agent for inhibiting tumor metastasis.

Abstract: A peptide-containing polyethylene glycol derivative represented by the following general formula [I] or [II]: ##STR1## wherein each R.sup.1 independently represents a peptide residue represented by the following general formula [IIIa] or [IIIa]:-([X]-Arg-Gly-Asp-[Y]).sub.m -Z [IIIa]([X]-Glu-Ile-Leu-Asp-val-Pro-Ser-Thr-[Y]).sub.m (IIIb)wherein Arg, Gly, Asp, Glu, Ile, Leu, val, Pro, Ser and Thr represent arginine, glycine, aspartic acid, glutamic acid, isoleucine, leucine, valine, proline, serine and threonine residue respectively; [X] and [Y] each represents an amino acid or peptide residue which may be present or absent; n is an integer ranging from 1 to 150; m is an integer ranging from 1 to 5 and Z represents --OH or --NH.sub.2, provided that the peptide residue [IIIb] and the triazine ring is bonded at the position of [X] (if [X] is absent, at the position of Glu) or [Y] (or if [Y] is absent, at the position of Thr) or a salt thereof.