Patent number: 8138335
Abstract: A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g.
Type:
Grant
Filed:
September 1, 2009
Date of Patent:
March 20, 2012
Assignee:
Ono Pharmaceutical Co., Ltd
Inventors:
Atsushi Naganawa, Maki Iwahashi, Atsushi Kinoshita, Atsushi Shimabukuro, Seiji Ogawa, Koji Yano, Kaoru Kobayashi, Yutaka Okada, Yoko Kishida, Shouji Kawauchi, Kohki Tsukamoto, Yoko Matsunaga, Fumio Nambu
Publication number: 20100029631
Abstract: A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g.
Type:
Application
Filed:
September 1, 2009
Publication date:
February 4, 2010
Applicant:
ONO Pharmaceutical Co., Ltd.
Inventors:
Atsushi Naganawa, Maki Iwahashi, Atsushi Kinoshita, Atsushi Shimabukuro, Seiji Ogawa, Koji Yano, Kaoru Kobayashi, Yutaka Okada, Yoko Kishida, Shouji Kawauchi, Kohki Tsukamoto, Yoko Matsunaga, Fumio Nambu
Patent number: 7601712
Abstract: A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g.
Type:
Grant
Filed:
September 16, 2004
Date of Patent:
October 13, 2009
Assignee:
Ono Pharmaceutical Co., Ltd.
Inventors:
Atsushi Naganawa, Maki Iwahashi, Atsushi Kinoshita, Atsushi Shimabukuro, Seiji Ogawa, Koji Yano, Kaoru Kobayashi, Yutaka Okada, Yoko Kishida, Shouji Kawauchi, Kohki Tsukamoto, Yoko Matsunaga, Fumio Nambu
Publication number: 20070004716
Abstract: A compound represented by formula (I) wherein the symbols in the formula are the same meanings as those in specification, salts thereof, solvates thereof, or prodrugs thereof binds to DP receptor and shows antagonistic activity for DP receptor. Thus, it is useful for prevention and/or treatment of diseases such as allergic disease (e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (e.g., atopic dermatitis and urticaria), diseases (e.g., cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (e.g.
Type:
Application
Filed:
September 16, 2004
Publication date:
January 4, 2007
Inventors:
Atsushi Naganawa, Maki Iwahashi, Atsushi Kinoshita, Atsushi Shimabukuro, SeijiKoji Ogawa, Koji Yano, Kaoru Kobayashi, Yutaka Okada, Yoko Kishida, Shouji Kawauchi, Kohki Tsukamoto, Yoko Matsunaga, Fumio Nambu