Abstract: A hollow-fiber membrane according to an aspect of the present disclosure contains a polytetrafluoroethylene or a modified polytetrafluoroethylene as a main component and has an average outer diameter of 1 mm or less and an average inner diameter of 0.5 mm or less. In a measurement of a heat of fusion of the polytetrafluoroethylene or the modified polytetrafluoroethylene with a differential scanning calorimeter, when the polytetrafluoroethylene or modified polytetrafluoroethylene is subjected to a first step of heating from room temperature to 365° C., a second step of cooling from 365° C. to 350° C., maintaining the temperature, subsequently cooling from 350° C. to 330° C., and further cooling from 330° C. to 305° C., and a third step of cooling from 305° C. to 245° C. at a rate of ?50° C./min and subsequently heating from 245° C. to 365° C. at a rate of 10° C./min, a heat of fusion from 296° C. to 343° C. in the third step is 30.0 J/g or more and 45.0 J/g or less.

Abstract: The present invention provides an oligodeoxynucleotide which comprises a CpG oligodeoxynucleotide comprising a nucleotide sequence represented by formula (1): 5?X-CpG-L-CpG-TZ3???(I) wherein X is T or C, L is a nucleotide sequence consisting of 1 to 7 bases, and Z is T or C, and consisting of 8 to 16 bases, and a polydeoxyadenylic acid having a length capable of forming a complex with a ?-1,3-glucan, wherein the polydeoxyadenylic acid is linked to the 3? side of the CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing said oligodeoxynucleotide and a ?-1,3-glucan.

Abstract: The present invention provides a hot-melt adhesive having a sufficiently long usable time and exhibiting good strength and good heat resistance. The present invention relates to a hot-melt adhesive composition comprising a hydrocarbon cyclic polymer (A), an ?-olefin polymer (C), and a tackifying resin (D).

Abstract: A hollow-fiber membrane module according to an embodiment of the present disclosure includes a rectangular tubular outer casing with at least one sidewall being open, the outer casing having a plurality of open ports, and an inner casing configured such that a plurality of hollow-fiber membranes aligned in a longitudinal direction of the outer casing are placeable in the inner casing and configured to be insertable into the one sidewall.

Abstract: An objective of the present invention is to provide a chemically-modified siRNA that has polydeoxyadenylic acid added to the 5? end of the sense strand, and, when complexed with schizophyllan, is high in resistance against RNase and moreover effectively exhibits RNAi activity. To achieve the objective, in the chemically-modified siRNA with polydeoxyadenylic acid added to the 5? end of the sense strand, specific chemical modification is performed for dinucleotide sequences of CA, UA, and UG in the base sequence of the sense strand and dinucleotide sequences of CA, UA, and UG in the base sequence at and after the eighth base from the 5? end of the antisense strand.

Abstract: A hollow-fiber membrane according to an aspect of the present disclosure contains a polytetrafluoroethylene or a modified polytetrafluoroethylene as a main component and has an average outer diameter of 1 mm or less and an average inner diameter of 0.5 mm or less. In a measurement of a heat of fusion of the polytetrafluoroethylene or the modified polytetrafluoroethylene with a differential scanning calorimeter, when the polytetrafluoroethylene or modified polytetrafluoroethylene is subjected to a first step of heating from room temperature to 365° C., a second step of cooling from 365° C. to 350° C., maintaining the temperature, subsequently cooling from 350° C. to 330° C., and further cooling from 330° C. to 305° C., and a third step of cooling from 305° C. to 245° C. at a rate of ?50° C./min and subsequently heating from 245° C. to 365° C. at a rate of 10° C./min, a heat of fusion from 296° C. to 343° C. in the third step is 30.0 J/g or more and 45.0 J/g or less.

Abstract: Chemically-modified siRNA may have polydeoxyadenylic acid added to the 5? end of the sense strand thereof, wherein when complexed with schizophyllan, the chemically-modified siRNA can be highly resistant to RNase and effectively exhibit RNAi activity. Modified siRNA may have polydeoxyadenylic acid at the 5? end of the sense strand thereof, based on a particular chemical modification is applied to CA, UA, and UG dinucleotide sequences in the base sequence of the sense strand thereof, and CA, UA, and UG dinucleotide sequences in the base sequence beyond the eighth base from the 5? end of the antisense strand thereof.

Abstract: An object of the present invention is to provide novel double-stranded RNA having an RNA interference effect, in which the cellular uptake and the resistance to enzymatic degradation are improved, without reducing the RNA interference effect.

Abstract: An object of the present invention is to provide novel double-stranded RNA having an RNA interference effect, in which the cellular uptake and the resistance to enzymatic degradation are improved, without reducing the RNA interference effect.

Abstract: An objective of the present invention is to provide a chemically-modified siRNA that has polydeoxyadenylic acid added to the 5? end of the sense strand, and, when complexed with schizophyllan, is high in resistance against RNase and moreover effectively exhibits RNAi activity. To achieve the objective, in the chemically-modified siRNA with polydeoxyadenylic acid added to the 5? end of the sense strand, specific chemical modification is performed for dinucleotide sequences of CA, UA, and UG in the base sequence of the sense strand and dinucleotide sequences of CA, UA, and UG in the base sequence at and after the eighth base from the 5? end of the antisense strand.

Abstract: A porous material according to an embodiment of the present invention is a porous material having a large number of fibrous skeletons containing polytetrafluoroethylene as a main component, in which another fluororesin is evenly present on outer peripheral surfaces of fibers of the large number of fibrous skeletons, and the other fluororesin is a tetrafluoroethylene/perfluorodioxole copolymer, a tetrafluoroethylene/perfluoromethyl vinyl ether copolymer, a tetrafluoroethylene/perfluoroethyl vinyl ether copolymer, a tetrafluoroethylene/perfluoropropyl vinyl ether copolymer, or a combination of these.

Abstract: A porous filter includes a porous laminate in which a plurality of biaxially stretched porous sheets made of PTFE are stacked. The Gurley number G and the bubble point B (kPa) of the porous laminate satisfy the following expressions (1) and (2): log G>3.7×10?3×B?0.8??(1) log G<4.9×10?3×B+0.45??(2).

Abstract: The present invention provides a hot-melt adhesive having a sufficiently long usable time and exhibiting good strength and good heat resistance. The present invention relates to a hot-melt adhesive composition comprising a hydrocarbon cyclic polymer (A), an ?-olefin polymer (C), and a tackifying resin (D).

Abstract: A low-cost cell culture device with low cytotoxicity and improved cell adhesion is described, manufactured by a simplified coating process. At least the portion for cell culture on the surface of the cell culture device is coated with at least one of ?-poly-L-lysine, further polymerized derivatives of ?-poly-L-lysine and their salts.

Abstract: A porous polytetrafluoroethylene film comprising a fluororesin containing polytetrafluoroethylene as a main component, wherein an envelope surface area of resin fibers included per film having an area of 1 m2 and a thickness of 25 ?m is 4,000 m2 or more, and a melting point peak is 333° C. or lower.

Abstract: A porous filter includes a porous laminate in which a plurality of biaxially stretched porous sheets made of PTFE are stacked. The Gurley number G and the bubble point B (kPa) of the porous laminate satisfy the following expressions (1) and (2): log G>3.7×10?3×B?0.8??(1) log G<4.9×10?3×B+0.45??(2).

Abstract: A porous polytetrafluoroethylene composite includes a porous polytetrafluoroethylene film, a porous support layer that supports the porous polytetrafluoroethylene film, an adhesive layer bonded to the porous polytetrafluoroethylene film, and a porous reinforcement layer bonded to the adhesive layer, in which the adhesive layer is a layer composed of a fluororesin having a melting point, or a glass transition point when a melting point is not clearly defined, of lower than 260° C.

Abstract: Provided is a method for producing a porous polytetrafluoroethylene film having good chemical resistance, good heat resistance, a high porosity, and good dimensional stability. The method for producing a porous polytetrafluoroethylene film includes a stretching step of stretching a sheet-like molded body composed of a fluororesin containing polytetrafluoroethylene as a main component in a longitudinal direction and/or a lateral direction at a temperature lower than a melting point of the fluororesin to make a porous fluororesin film, and, after the stretching step, an annealing step of holding the porous fluororesin film in a shape-fixed state, and maintaining the porous fluororesin film at a temperature lower than the melting point of the fluororesin but not lower than a temperature 30° C. lower than the melting point for 1 to 20 hours.

Abstract: The invention offers a microporous modified-polytetrafluoroethylene membrane that is a microporous membrane having a significantly small pore diameter and narrow pore-diameter distribution and that can remove microscopic foreign particles at high efficiency when used as a filtration membrane.

Abstract: Provided is a method for producing a porous polytetrafluoroethylene film having good chemical resistance, good heat resistance, a high porosity, and good dimensional stability. The method for producing a porous polytetrafluoroethylene film includes a stretching step of stretching a sheet-like molded body composed of a fluororesin containing polytetrafluoroethylene as a main component in a longitudinal direction and/or a lateral direction at a temperature lower than a melting point of the fluororesin to make a porous fluororesin film, and, after the stretching step, an annealing step of holding the porous fluororesin film in a shape-fixed state, and maintaining the porous fluororesin film at a temperature lower than the melting point of the fluororesin but not lower than a temperature 30° C. lower than the melting point for 1 to 20 hours.