Patents by Inventor Attilio Bondanza

Attilio Bondanza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TCR AND PEPTIDES
    Publication number: 20240132569
    Abstract: A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC).
    Type: Application
    Filed: January 20, 2023
    Publication date: April 25, 2024
    Inventors: Maria Chiara Bonini, Eliana Ruggiero, Zulma Irene Magnani, Luca Aldo Edoardo Vago, Attilio Bondanza, Fabio Ciceri
  • METHODS FOR EXPANDING T CELL POPULATIONS
    Publication number: 20240117309
    Abstract: Provided herein are methods for manufacturing, expanding, and/or generating genetically modified T cells comprising a chimeric antigen receptor (CAR) or T-cell receptor (TCR).
    Type: Application
    Filed: July 13, 2023
    Publication date: April 11, 2024
    Inventors: Jinlin JIANG, Emily BOSCO, Christina GRIGORIADOU, Maria Letizia GIARDINO TORCHIA, Gordon MOODY, Attilio BONDANZA, Nina CHU
  • METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS
    Publication number: 20230256017
    Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.
    Type: Application
    Filed: February 26, 2021
    Publication date: August 17, 2023
    Inventors: Jennifer BROGDON, Glenn DRANOFF, Michael R. GREENE, Anniesha HACK, Olja KODRASI, Elizabeth Dorothy PRATICO, Andrew PRICE, Andrew Marc STEIN, Amy RAYO, Jennifer YANG, Brian Walter GRANDA, Attilio BONDANZA, Boris ENGELS, Hyungwook LIM, Akash SOHONI, Louise TREANOR, Xu ZHU, Carla GUIMARAES, Shyamali JAYASHANKAR, Sandeep Tharian KOSHY, Regis CEBE, Michael BARDROFF, Sandra MILLER
  • METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS
    Publication number: 20230174933
    Abstract: This disclosure provides methods of making immune effector cells (for example, T cells, NK cells) that comprise (i) a nucleic acid molecule that encodes a controllable chimeric antigen receptor (CCAR) or (ii) a nucleic acid molecule that encodes a CAR and a regulatory molecule, and compositions generated by such methods.
    Type: Application
    Filed: February 26, 2021
    Publication date: June 8, 2023
    Inventors: Jennifer BROGDON, Seth CARBONNEAU, Glenn DRANOFF, Michael R. Greene, Anniesha HACK, Marc Horst Peter HILD, Olja KODRASI, Elizabeth Dorothy PRATICO, Andrew PRICE, Andrew Marc STEIN, Attilio BONDANZA, Boris ENGELS, Carla Patricia Pinto GUIMARAES, Hyungwook LIM, Sujata SHARMA, Akash SOHONI, Louise TREANOR, Xu ZHU
  • TCR and peptides
    Patent number: 11597755
    Abstract: TCR AND PEPTIDES A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC).
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: March 7, 2023
    Assignees: Ospedale San Raffaele S.r.l., Fondazione Centro San Raffaele
    Inventors: Maria Chiara Bonini, Eliana Ruggiero, Zulma Irene Magnani, Luca Aldo Edoardo Vago, Attilio Bondanza, Fabio Ciceri
  • METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS
    Publication number: 20220364055
    Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.
    Type: Application
    Filed: August 30, 2019
    Publication date: November 17, 2022
    Inventors: Louise Treanor, Michael R. Greene, Jennifer Brogdon, Boris Engels, Glenn Dranoff, Olja Kodrasi, Hyungwook Lim, Akash Sohoni, Elizabeth Dorothy Pratico, Anniesha Hack, Aida Abujoub, Tony Fleming, Lu Huang, Connie Hong, John Blankenship, Brian Holmberg, Chonghui Zhang, Dexiu Bu, Andrew Price, Xu Zhu, Andrew Stein, Attilio Bondanza
  • Use of common gamma chain cytokines for the visualization, isolation and genetic modification of memory T lymphocytes
    Patent number: 11395835
    Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: July 26, 2022
    Assignee: OSPEDALE SAN RAFFAELE S.R.L.
    Inventors: Maria Chiara Bonini, Attilio Bondanza
  • Chimeric antigen receptors
    Patent number: 11299529
    Abstract: A chimeric antigen receptor (CAR) comprising an extracellular spacer which comprises at least part of the extracellular domain of human low affinity nerve growth factor (LNGFR) or a derivative thereof.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: April 12, 2022
    Assignee: AGC Biologics S.p.A.
    Inventors: Attilio Bondanza, Monica Casucci, Maria Chiara Bonini
  • COMBINATION OF A GLYCOSYLATION INHIBITOR WITH ONE CAR CELL THERAPY FOR TREATING CANCER
    Publication number: 20210290646
    Abstract: The present invention relates to at least one glycosylation inhibitor for use in combination with CAR cell therapy. Preferably, the glycosylation inhibitor improves the therapeutic potential of the CAR cell therapy. The invention also relates to a pharmaceutical composition and to population or subpopulation of CAR cell that has been contacted with at least one glycosylation inhibitor.
    Type: Application
    Filed: July 22, 2019
    Publication date: September 23, 2021
    Applicants: OSPEDALE SAN RAFFAELE S.R.L., FONDAZIONE CENTRO SAN RAFFAELE
    Inventors: Attilio BONDANZA, Monica CASUCCI, Beatrice GRECO
  • CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
    Publication number: 20210220404
    Abstract: The invention provides immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions and methods thereof.
    Type: Application
    Filed: November 25, 2020
    Publication date: July 22, 2021
    Inventors: Aida Abujoub, John Blankenship, Attilio Bondanza, Jennifer Brogdon, Dexiu Bu, Serena De Vita, Glenn Dranoff, Boris Engels, Tony Fleming, Brian Walter Granda, Michael R. Greene, Carla Patricia Guimaraes, Anniesha Hack, Brian Holmberg, Connie Hong, Lu Huang, Olja Kodrasi, Joni Waiee Lam, Hyungwook Lim, Elizabeth Dorothy Pratico, Andrew Price, Akash Sohoni, Andrew Marc Stein, Louise Treanor, Chonghui Zhang, Xu Zhu
  • IL-1 ANTAGONIST AND TOXICITY INDUCED BY CELL THERAPY
    Publication number: 20210046159
    Abstract: The present invention relates to a IL-1 antagonist alone or in combination with other therapeutic agents and relative pharmaceutical compositions for use for the treatment and/or prevention of toxicity induced by a T cell therapy, wherein the T cell expresses at least one recombinant receptor.
    Type: Application
    Filed: March 8, 2019
    Publication date: February 18, 2021
    Applicants: OSPEDALE SAN RAFFAELE S.R.L., FONDAZIONE CENTRO SAN RAFFAELE
    Inventors: Attilio BONDANZA, Barbara CAMISA, Margherita NORELLI
  • TCR AND PEPTIDES
    Publication number: 20200123220
    Abstract: TCR AND PEPTIDES A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC).
    Type: Application
    Filed: April 24, 2018
    Publication date: April 23, 2020
    Inventors: Maria Chiara Bonini, Eliana Ruggiero, Zulma Irene Magnani, Luca Aldo Edoardo Vago, Attilio Bondanza, Fabio Ciceri
  • USE OF COMMON GAMMA CHAIN CYTOKINES FOR THE VISUALIZATION, ISOLATION AND GENETIC MODIFICATION OF MEMORY T LYMPHOCYTES
    Publication number: 20180333434
    Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
    Type: Application
    Filed: May 4, 2018
    Publication date: November 22, 2018
    Inventors: Maria Chiara Bonini, Attilio Bondanza
  • Use of common ? chain cytokines for the visualization, isolation and genetic modification of memory T lymphocytes
    Patent number: 9974808
    Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: May 22, 2018
    Assignee: OSPEDALE SAN RAFFAELE S.R.L.
    Inventors: Maria Chiara Bonini, Attilio Bondanza
  • Chimeric Antigen Receptors
    Publication number: 20170247428
    Abstract: A chimeric antigen receptor (CAR) comprising an extracellular spacer which comprises at least part of the extracellular domain of human low affinity nerve growth factor (LNGFR) or a derivative thereof.
    Type: Application
    Filed: September 14, 2015
    Publication date: August 31, 2017
    Inventors: Attilio Bondanza, Monica Casucci, Maria Chiara Bonni
  • USE OF COMMON GAMMA CHAIN CYTOKINES FOR THE VISUALIZATION, ISOLATION AND GENETIC MODIFICATION OF MEMORY T LYMPHOCYTES
    Publication number: 20150306142
    Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
    Type: Application
    Filed: March 17, 2015
    Publication date: October 29, 2015
    Inventors: Maria Chiara BONINI, Attilio BONDANZA
  • Use of common ? chain cytokines for the visualization, isolation and genetic modification of memory T lymphocytes
    Patent number: 8999715
    Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: April 7, 2015
    Assignee: Ospedale San Raffaele S.R.L.
    Inventors: Maria Chiara Bonini, Attilio Bondanza
  • USE OF COMMON GAMMA CHAIN CYTOKINES FOR THE VISUALIZATION, ISOLATION AND GENETIC MODIFICATION OF MEMORY T LYMPHOCYTES
    Publication number: 20120027802
    Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
    Type: Application
    Filed: September 22, 2011
    Publication date: February 2, 2012
    Applicant: FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
    Inventors: Maria Chiara BONINI, Attilio BONDANZA
  • USE OF COMMON GAMMA CHAIN CYTOKINES FOR THE VISUALIZATION, ISOLATION AND GENETIC MODIFICATION OF MEMORY T LYMPHOCYTES
    Publication number: 20100035282
    Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
    Type: Application
    Filed: August 3, 2006
    Publication date: February 11, 2010
    Inventors: Maria Chiara Bonini, Attilio Bondanza, Anna Mondino, Stefano Caserta