Patents by Inventor Audrey LEE-GOSSELIN

Audrey LEE-GOSSELIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermal bioswitches and related genetic circuits, vectors, cells, compositions, methods and systems
    Patent number: 11959127
    Abstract: Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: April 16, 2024
    Assignee: California Institute of Technology
    Inventors: Mikhail G. Shapiro, Dan Piraner, Mohamad H. Abedi, Brittany Moser, Audrey Lee-Gosselin
  • GENETICALLY ENGINEERED GAS VESICLE GENE CLUSTERS, GENETIC CIRCUITS, VECTORS, PROKARYOTIC CELLS, COMPOSITIONS, METHODS AND SYSTEMS FOR CONTRAST-ENHANCED IMAGING
    Publication number: 20210301298
    Abstract: Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site.
    Type: Application
    Filed: May 31, 2021
    Publication date: September 30, 2021
    Inventors: Raymond W. BOURDEAU, Anupama LAKSHMANAN, Arash FARHADI, Mikhail G. SHAPIRO, Audrey LEE-GOSSELIN
  • Genetically engineered gas vesicle gene clusters, genetic circuits, vectors, prokaryotic cells, compositions, methods and systems for contrast-enhanced imaging
    Patent number: 11118210
    Abstract: Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: September 14, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Raymond W. Bourdeau, Anupama Lakshmanan, Arash Farhadi, Mikhail G. Shapiro, Audrey Lee-Gosselin
  • THERMAL BIOSWITCHES AND RELATED GENETIC CIRCUITS, VECTORS, CELLS, COMPOSITIONS, METHODS AND SYSTEMS
    Publication number: 20210277453
    Abstract: Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.
    Type: Application
    Filed: March 17, 2021
    Publication date: September 9, 2021
    Inventors: Mikhail G. SHAPIRO, Dan I. PIRANER, Mohamad H. ABEDI, Brittany MOSER, Audrey LEE-GOSSELIN
  • Thermal bioswitches and related genetic circuits, vectors, cells, compositions, methods and systems
    Patent number: 10975420
    Abstract: Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: April 13, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Mikhail G. Shapiro, Dan I. Piraner, Mohamad H. Abedi, Brittany Moser, Audrey Lee-Gosselin
  • GENETICALLY ENGINEERED GAS VESICLE GENE CLUSTERS, GENETIC CIRCUITS, VECTORS, PROKARYOTIC CELLS, COMPOSITIONS, METHODS AND SYSTEMS FOR CONTRAST-ENHANCED IMAGING
    Publication number: 20180030501
    Abstract: Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site.
    Type: Application
    Filed: July 28, 2017
    Publication date: February 1, 2018
    Inventors: Raymond W. BOURDEAU, Anupama LAKSHMANAN, Arash FARHADI, Mikhail G. SHAPIRO, Audrey LEE-GOSSELIN
  • THERMAL BIOSWITCHES AND RELATED GENETIC CIRCUITS, VECTORS, CELLS, COMPOSITIONS, METHODS AND SYSTEMS
    Publication number: 20170298425
    Abstract: Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described.
    Type: Application
    Filed: December 19, 2016
    Publication date: October 19, 2017
    Inventors: Mikhail G. SHAPIRO, Dan I. PIRANER, Mohamad H. ABEDI, Brittany MOSER, Audrey LEE-GOSSELIN