Patents by Inventor Avinoam Kadouri
Avinoam Kadouri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11185572Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.Type: GrantFiled: July 27, 2018Date of Patent: November 30, 2021Assignees: Ramot at Tel-Aviv University Ltd., BrainStorm Ceil Therapeutics Ltd.Inventors: Avinoam Kadouri, Avihay Bar-Ilan, Eldad Melamed, Daniel Offen, Ofer Sadan, Merav Bahat-Stromza
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Publication number: 20180333458Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.Type: ApplicationFiled: July 27, 2018Publication date: November 22, 2018Applicants: Ramot at Tel-Aviv University Ltd., BrainStorm Cell Therapeutics Ltd.Inventors: Avinoam KADOURI, Avihay BAR-ILAN, Eldad MELAMED, Daniel OFFEN, Ofer SADAN, Merav BAHAT-STROMZA
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Patent number: 10052363Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.Type: GrantFiled: September 11, 2016Date of Patent: August 21, 2018Assignees: Ramot at Tel-Aviv University Ltd., Brainstorm Cell Therapeutics Ltd.Inventors: Avinoam Kadouri, Avihay Bar-Ilan, Eldad Melamed, Daniel Offen, Ofer Sadan, Merav Bahat-Stromza
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Publication number: 20160375098Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.Type: ApplicationFiled: September 11, 2016Publication date: December 29, 2016Applicants: Ramot at Tel-Aviv University Ltd., BrainStorm Cell Therapeutics Ltd.Inventors: Avinoam KADOURI, Avihay BAR-ILAN, Eldad MELAMED, Daniel OFFEN, Ofer SADAN, Merav BAHAT-STROMZA
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Patent number: 9474787Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.Type: GrantFiled: December 1, 2014Date of Patent: October 25, 2016Assignees: Ramot at Tel-Aviv University Ltd., BrainStorm Cell Therapeutics Ltd.Inventors: Avinoam Kadouri, Avihay Bar-Ilan, Eldad Melamed, Daniel Offen, Ofer Sadan, Merav Bahat-Stromza
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Publication number: 20150086517Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.Type: ApplicationFiled: December 1, 2014Publication date: March 26, 2015Inventors: Avinoam Kadouri, Avihay Bar-Ilan, Eldad Melamed, Daniel Offen, Ofer Sadan, Merav Bahat-Stromza
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Patent number: 8900574Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.Type: GrantFiled: January 27, 2014Date of Patent: December 2, 2014Assignees: Ramot at Tel-Aviv University Ltd., BrainStorm Cell Therapeutics Ltd.Inventors: Avinoam Kadouri, Avihay Bar-Ilan, Eldad Melamed, Daniel Offen, Ofer Sadan, Merav Bahat-Stromza
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Publication number: 20140140968Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.Type: ApplicationFiled: January 27, 2014Publication date: May 22, 2014Applicants: BrainStorm Cell Therapeutics Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Avinoam KADOURI, Avihay BAR-ILAN, Eldad MELAMED, Daniel OFFEN, Ofer SADAN, Merav BAHAT-STROMZA
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Patent number: 8663987Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.Type: GrantFiled: May 26, 2009Date of Patent: March 4, 2014Assignees: Ramot at Tel-Aviv University Ltd., BrainStorm Cell Therapeutics Ltd.Inventors: Avinoam Kadouri, Avihay Bar-Ilan, Eldad Melamed, Daniel Offen, Ofer Sadan, Merav Bahat-Stromza
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METHOD AND APPARATUS FOR MAINTENANCE AND EXPANSION OF HEMOPOIETIC STEM CELLS AND/OR PROGENITOR CELLS
Publication number: 20120122220Abstract: A method of preparing a stromal cell conditioned medium useful in expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) establishing a stromal cell culture in a stationary phase plug-flow bioreactor under continuous flow on a substrate in the form of a sheet, the substrate including a non-woven fibrous matrix forming a physiologically acceptable three-dimensional network of fibers, thereby expanding undifferentiated hemopoietic stem cells ; and (b) when a desired stromal cell density has been achieved, collecting medium from the stationary phase plug-flow bioreactor, thereby obtaining the stromal cell conditioned medium useful in expanding the undifferentiated hemopoietic stem cells.Type: ApplicationFiled: January 27, 2012Publication date: May 17, 2012Inventors: Shoshana Merchav, Shai Meretski, Dov Zipori, Avinoam Kadouri -
Publication number: 20120009673Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.Type: ApplicationFiled: May 26, 2009Publication date: January 12, 2012Applicants: BrainStorm Cell Therapeutics Inc., RAMOT AT TEL-AVIV UNIVERSITY LTD.Inventors: Avinoam Kadouri, Avihay Bar-llan, Eidad Melamed, Daniel Offen, Ofer Sadan, Merav Bahat-Stromza
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Patent number: 7678573Abstract: A method of preparing a stromal cell conditioned medium useful in expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) establishing a stromal cell culture in a stationary phase plug-flow bioreactor under continuous flow on a substrate in the form of a sheet, the substrate including a non-woven fibrous matrix forming a physiologically acceptable three-dimensional network of fibers, thereby expanding undifferentiated hemopoietic stem cells; and (b) when a desired stromal cell density has been achieved, collecting medium from the stationary phase plug-flow bioreactor, thereby obtaining the stromal cell conditioned medium useful in expanding the undifferentiated hemopoietic stem cells.Type: GrantFiled: April 11, 2005Date of Patent: March 16, 2010Assignee: Pluristem Ltd.Inventors: Shoshana Merchav, Shai Meretski, Dov Zipori, Avinoam Kadouri
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Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
Publication number: 20090004738Abstract: A method of preparing a stromal cell conditioned medium useful in expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) establishing a stromal cell culture in a stationary phase plug-flow bioreactor under continuous flow on a substrate in the form of a sheet, the substrate including a non-woven fibrous matrix forming a physiologically acceptable three-dimensional network of fibers, thereby expanding undifferentiated hemopoietic stem cells; and (b) when a desired stromal cell density has been achieved, collecting medium from the stationary phase plug-flow bioreactor, thereby obtaining the stromal cell conditioned medium useful in expanding the undifferentiated hemopoietic stem cells.Type: ApplicationFiled: September 2, 2008Publication date: January 1, 2009Applicant: Pluristem Life Systems Inc.Inventors: Shoshana Merchav, Shai Meretski, Dov Zipori, Avinoam Kadouri -
Patent number: 5705390Abstract: A radial flow bioreactor comprising a reaction vessel having an inlet and an outlet respectively for adding and withdrawing a culture medium and at least one cell basket within the reaction vessel for accommodating a plurality of cell carriers and having side wall perforations so dimensioned as to prevent passage of the cell carriers therethrough.Type: GrantFiled: April 14, 1995Date of Patent: January 6, 1998Assignee: InterPharm Laboratories Ltd.Inventors: Avinoam Kadouri, Yehoshua Aloni, Mordechai Geron
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Patent number: 5501971Abstract: A method and apparatus cultivates anchorage and nonanchorage cell in a reactor. A reactor includes a basket type packed bed and an internal recirculation device. The basket includes a top and bottom portion for allowing medium to flow uniformly through the basket. Medium flows downwardly from the top of the basket through the basket for providing gentle flow and preventing removal of cells from the carrier. Preferably, the carrier is formed of a fiber matrix.Type: GrantFiled: November 30, 1994Date of Patent: March 26, 1996Assignee: New Brunswick Scientific Co., Inc.Inventors: David Freedman, Guozheng Wang, Avinoam Kadouri
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Patent number: 5266476Abstract: There is provided a matrix and cultivation system for anchorage dependent cells. The matrix is characterized by a substantially increased available effective surface area for cell attachment which is attained by resorting to the use of a fiber network or open-pore foams with suitable pore size. Attachment of the cells can be enhanced by modifying the surface of the substrate. One embodiment comprises a matrix in particle or flake form.Type: GrantFiled: April 14, 1992Date of Patent: November 30, 1993Assignee: Yeda Research & Development Co., Ltd.Inventors: Martin Sussman, Zvi Bohak, Avinoam Kadouri
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Patent number: 5168058Abstract: The invention relates to packing material for use in the cultivation of anchorage-dependent cells, which require a solid surface for proliferation. The packing material of the invention is provided in the form of units of curved sheet material, which individual units generally have a thickness of about 0.05 mm to 0.25 mm, the other dimensions being of the order of one to a few millimeter maximum dimensions. Various shapes can be used, such as twisted rectangles, segments of cylinders, convulated ribbons, twisted shapes, ring shape and the like.Type: GrantFiled: June 27, 1990Date of Patent: December 1, 1992Assignee: Yeda Research and Development Company, Ltd.Inventors: Zvi Bohak, Avinoam Kadouri, Nicholas G. Maroudas