Patents by Inventor Avner SCHLESSINGER

Avner SCHLESSINGER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF AMINO ACID TRANSPORT
    Publication number: 20230416199
    Abstract: Disclosed herein are compounds and compositions of formula I that are inhibitors of amino acid transport, specifically alanine serine cysteine transporter 2 (ASCT2): These compounds are useful as therapeutic agents for treating various cancers. Methods for inhibiting an ASCT2 transporter are also disclosed. Certain compounds are selective for an ASCT transporter.
    Type: Application
    Filed: October 22, 2021
    Publication date: December 28, 2023
    Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Christof GREWER, Avner SCHLESSINGER, Elias NDARU, Yueyue SHI, Laura Jane ZIELEWICZ
  • Kinase inhibitor compounds and compositions and methods of use
    Patent number: 11547712
    Abstract: The present invention is directed to kinase inhibitor compounds having the following structure: or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, X, n, R3, Y, Z, R4, R5, R6, and = are as defined herein. The present invention also relates to compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: January 10, 2023
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Robert Devita, Andrew Stewart, Avner Schlessinger, Kunal Kumar, Peter Man-Un Ung, Hui Wang, Hailing Li
  • Compositions and Methods for Treating or Preventing Endocrine FGF23-Linked Diseases
    Publication number: 20200331978
    Abstract: The present invention provides compositions and methods that are useful in treating or preventing endocrine FGF-related diseases or disorders, such as but not limited to dysfunctional phosphate homeostasis and chronic kidney disease (CKD).
    Type: Application
    Filed: December 12, 2018
    Publication date: October 22, 2020
    Inventors: Joseph Schlessinger, Sangwon Lee, Avner Schlessinger, Man-Un Ung
  • KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE
    Publication number: 20200306257
    Abstract: The present invention is directed to kinase inhibitor compounds having the following structure: or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, X, n, R3, Y, Z, R4, R5, R6, and = are as defined herein. The present invention also relates to compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.
    Type: Application
    Filed: November 20, 2018
    Publication date: October 1, 2020
    Inventors: Robert DEVITA, Andrew STEWART, Avner SCHLESSINGER, Kunal KUMAR, Peter MAN-UN UNG, Hui WANG, Hailing LI