Abstract: The invention relates to an intracorporeal guide component (1) for guiding lines belonging to medical devices inside a living being. The guide component (1) has a main body (2) comprising a line channel (3) for receiving and guiding the line. To secure the guide component (1) in the body of the living being more easily, with less damage to the tissue, according to the invention the main body (2) has, on its periphery, one or more contact surfaces (4, 4b) designed for interlocking and/or frictional contact with a bone structure of the living being. For example, the guide component (1) can be clamped between two costal arches of the living being, as an intercostal guide component (1), in order to securely hold and guide a line leading to the heart of the living being.

Abstract: The invention relates to a method for producing a bioartificial and primarily acellular fibrin-based construct, wherein a mixture of cell-free compositions containing fibrinogen and thrombin is applied to a surface and subsequently pressurised. An additional aspect of the invention is directed to such fibrin-based bioartificial acellular constructs obtained according to the invention, with improved biomechanical properties, as well as to the use of same in the field of implantology, cartilage replacement or tissue replacement.

Abstract: A medical implant which is vacuum-packed within an air tight cover material and a medical device for making the same is provided. Also described herein is a method for making a medical implant covered by an air tight cover material, comprising the steps of a) providing the medical implant, b) providing sterile cover material in the form of at least one or at least two pieces, c) placing the medical implant within a space surrounded by the at least one or at least two pieces of the cover material, d) creating an underpressure within the space surrounded by the at least one or at least two pieces of the cover material by evacuating air from this space, and e) air tight sealing of the cover material.

Abstract: The invention relates to a method for producing a bioartificial and primarily acellular fibrin-based construct, wherein a mixture of cell-free compositions containing fibrinogen and thrombin is applied to a surface and subsequently pressurised. An additional aspect of the invention is directed to such fibrin-based bioartificial acellular constructs obtained according to the invention, with improved biomechanical properties, as well as to the use of same in the field of implantology, cartilage replacement or tissue replacement.

Abstract: The tissue construct with viable cells in an extracellular matrix made of fibrin is produced with a special method, in which a matrix material and cells are shaped into a hollow body, in particular a tubular hollow body, by means of a rotational casting method in a hollow mould (1), the method comprising the following steps: (a) introduction of cells of at least one cell type and/or a fibrinogen preparation into the rotating hollow mould (1) with the aid of an applicator (4), said applicator (4) being displaced along the rotational axis during the introduction and step (a) being performed one or more times; (b) continuation of the rotation process until the fibrinogen solidifies into a dimensionally stable matrix, obtaining a primarily solidified tissue construct; (c) removal of the tissue construct from the mould. The construct can also he obtained in a relatively short time from autologous materials.

Abstract: The invention relates to a lighting device (100), which is equipped for fastening to a surgical instrument (200) or, by means of adapter (90; 91), to a body part (92), in particular a finger of a surgeon or of an operating room assistant, in order to serve as a light source during a surgical operation, in particular within a body cavity or organ cavity of genuine or traumatic origin and in other body regions that are difficult to access. At least one pin (20) pointing outward from the wall of the housing (10) is arranged on the housing (10) of the lighting device (100) in a wall area (30) directed toward the surgical instrument in the fastening position, which pin has a light emitting opening (40) at the distal end of the pin and is designed for passing through an opening (220) of the surgical instrument or of the adapter (90; 91) and thus establishing a form-closed or force-closed connection to the opening. The pin (20) is preferably movable in order to achieve optimal illumination of the operation site.

Abstract: The present invention relates to a medical implant which is vacuum-packed within an air tight cover material. Further, the present invention relates to a medical device for making a medical implant covered by an air tight cover material, wherein the medical device comprises at least an underpressure generating device and a sealing device, wherein the sealing device is arranged for air tight sealing of the cover material while the medical implant is located within the cover material, wherein the underpressure generating device is coupled or can be coupled with a space which is surrounded by the cover material, and wherein the underpressure generating device and the sealing device are controllable such that after generating a certain underpressure within the space surrounded by the cover material through the underpressure generating device the sealing device is activatable to seal the cover material in an air tight manner to form an air tight protection cover around the medical implant located therein.

Abstract: The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (EPC) which have not been passaged multiple times and have a content of EOEC (early outgrowth endothelial progenitor cells) and LOEC (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz. myoblasts, myofibroblasts, smooth muscle cells or the progenitors thereof, are, in the form of living cells, seeded onto a matrix or introduced into a matrix in order to yield the tissue construct following further treatment steps. The matrix is preferably a protein preparation, more particularly a fibrinogen preparation. Both the cells and the fibrinogen preparation can be obtained from a single blood sample from a patient. Apart from the preparation of bypass materials, prosthetic vascular graft, tissue patches, conduits and the like, the EOEC-containing EPC culture or suspension is suitable as means for cell transplantation.

Abstract: The invention relates to a method for producing a bioartificial and primarily acellular fibrin-based construct, wherein a mixture of cell-free compositions containing fibrinogen and thrombin is applied to a surface and subsequently pressurised. An additional aspect of the invention is directed to such fibrin-based bioartificial acellular constructs obtained according to the invention, with improved biomechanical properties, as well as to the use of same in the field of implantology, cartilage replacement or tissue replacement.

Abstract: The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (EPC) which have not been passaged multiple times and have a content of EOEC (early outgrowth endothelial progenitor cells) and LOEC (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz. myoblasts, myofibroblasts, smooth muscle cells or the progenitors thereof, are, in the form of living cells, seeded onto a matrix or introduced into a matrix in order to yield the tissue construct following further treatment steps. The matrix is preferably a protein preparation, more particularly a fibrinogen preparation. Both the cells and the fibrinogen preparation can be obtained from a single blood sample from a patient. Apart from the preparation of bypass materials, prosthetic vascular graft, tissue patches, conduits and the like, the EOEC-containing EPC culture or suspension is suitable as means for cell transplantation.

Abstract: The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (EPC) which have not been passaged multiple times and have a content of EOEC (early outgrowth endothelial progenitor cells) and LOEC (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz. myoblasts, myofibroblasts, smooth muscle cells or the progenitors thereof, are, in the form of living cells, seeded onto a matrix or introduced into a matrix in order to yield the tissue construct following further treatment steps. The matrix is preferably a protein preparation, more particularly a fibrinogen preparation. Both the cells and the fibrinogen preparation can be obtained from a single blood sample from a patient. Apart from the preparation of bypass materials, prosthetic vascular graft, tissue patches, conduits and the like, the EOEC-containing EPC culture or suspension is suitable as means for cell transplantation.

Abstract: The present invention relates to a medical implant which is vacuum-packed within an air tight cover material. Further, the present invention relates to a medical device for making a medical implant covered by an air tight cover material, wherein the medical device comprises at least an underpressure generating device and a sealing device, wherein the sealing device is arranged for air tight sealing of the cover material while the medical implant is located within the cover material, wherein the underpressure generating device is coupled or can be coupled with a space which is surrounded by the cover material, and wherein the underpressure generating device and the sealing device are controllable such that after generating a certain underpressure within the space surrounded by the cover material through the underpressure generating device the sealing device is activatable to seal the cover material in an air tight manner to form an air tight protection cover around the medical implant located therein.

Abstract: A method for designing or replicating a human or animal organ in the form of a functional model includes providing previously recorded structural-geometric data of the organ or organ part to be replicated, selecting reconstruction materials for the organ or organ part, allocating the structural-geometric data to the individually selected reconstruction materials, and carrying out a layered assembly by the model by successively applying site-selective assembly methods for at least one part of the reconstruction materials on the basis of an associated data set.

Abstract: The invention relates to a lighting device (100), which is equipped for fastening to a surgical instrument (200) or, by means of adapter (90; 91), to a body part (92), in particular a finger of a surgeon or of an operating room assistant, in order to serve as a light source during a surgical operation, in particular within a body cavity or organ cavity of genuine or traumatic origin and in other body regions that are difficult to access. At least one pin (20) pointing outward from the wall of the housing (10) is arranged on the housing (10) of the lighting device (100) in a wall area (30) directed toward the surgical instrument in the fastening position, which pin has a light emitting opening (40) at the distal end of the pin and is designed for passing through an opening (220) of the surgical instrument or of the adapter (90; 91) and thus establishing a form-closed or force-closed connection to the opening. The pin (20) is preferably movable in order to achieve optimal illumination of the operation site.

Abstract: The invention relates to a vessel connector (10) for surgically connecting two vessels and/or prosthetics to each other, comprising a sleeve-shaped body (1), the walls of which are designed to be elastic, such that the force acting on the ligature or suture is limited to the extent that no pressure points or necroses occur in the vessel. It is made of two substantially rigid outer rings (2), delimiting the sleeve-shaped body, and webs (3) present between the rings, wherein at least regions of individual webs have a shape (4) deviating from a straight line over longer distances, and it has at least one ring-shaped region (5) of higher elasticity between the rigid rings. The connector provides a blood-tight connection of at least two natural or artificial vessels, including prosthetic connections, a prosthesis to a natural vessel, or two prostheses to each other.

Abstract: The tissue construct with viable cells in an extracellular matrix made of fibrin is produced with a special method, in which a matrix material and cells are shaped into a hollow body, in particular a tubular hollow body, by means of a rotational casting method in a hollow mould (1), the method comprising the following steps: (a) introduction of cells of at least one cell type and/or a fibrinogen preparation into the rotating hollow mould (1) with the aid of an applicator (4), said applicator (4) being displaced along the rotational axis during the introduction and step (a) being performed one or more times; (b) continuation of the rotation process until the fibrinogen solidifies into a dimensionally stable matrix, obtaining a primarily solidified tissue construct; (c) removal of the tissue construct from the mould. The construct can also he obtained in a relatively short time from autologous materials.

Abstract: The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (EPC) which have not been passaged multiple times and have a content of EOEC (early outgrowth endothelial progenitor cells) and LOEC (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz. myoblasts, myofibroblasts, smooth muscle cells or the progenitors thereof, are, in the form of living cells, seeded onto a matrix or introduced into a matrix in order to yield the tissue construct following further treatment steps. The matrix is preferably a protein preparation, more particularly a fibrinogen preparation. Both the cells and the fibrinogen preparation can be obtained from a single blood sample from a patient. Apart from the preparation of bypass materials, prosthetic vascular graft, tissue patches, conduits and the like, the EOEC-containing EPC culture or suspension is suitable as means for cell transplantation.

Abstract: A method for performing cardiovascular and surgical procedures includes providing a conduit in the form of a graft/canula placed using balloon dilatation catheter and providing a fixing mechanism for the graft/canula. At least one opening is formed through a wall of the heart substantially at the apex. The escape of blood is prevented through the use of the fixing mechanism. Each of these steps is performed while the heart is beating.

Abstract: A method for designing or replicating a human or animal organ in the form of a functional model includes providing previously recorded structural-geometric data of the organ or organ part to be replicated, selecting reconstruction materials for the organ or organ part, allocating the structural-geomtric data to the individually selected reconstruction materials, and carrying out a layered assembly by the model by successively applying site-selective assembly methods for at least one part of the reconstruction materials on the basis of an associated data set.

Abstract: Methods and devices are provided for improving cardiac output. The methods involve establishing a fluid communication pathway between the left ventricle and another natural or prosthetic structure. In one method, a conduit is implanted between the left ventricle and the descending aorta where ventricular blood flows from the left ventricle directly into the descending aorta and bypassing the aortic valve. The devices include such conduits and valves for forming the fluid communication pathways.