Abstract: The invention concerns a new method for automatically and dynamically generating hierarchical topological trees of 2D- or 3D-structural formulas for structurally characterized chemical compounds, especially drug-like molecules, wherein the molecular graph of each 2D- or 3D-structure for a chemical compound is analyzed in terms of topological key features, the Largest Topological Substructure (LTS) and the proper Topological Cluster Centre (TCC) are created for each molecular graph, the ranking of the classes of topological key features and/or the ranking within each class of topological key features present in the TCC is used to generate a connected hierarchical Topological Sequence Path (TSP) of sentinel molecules from each molecular graph, and different molecular graphs and their Topological Sequence Paths (TSPs) share common vertices for common topological key features thus growing a Topological Structure Tree (TST), each chemical compound from the input stream is attached as a leaf node to the appropriate

Abstract: The length and attenuation of a signal line between a transmitter and a customer premises equipment is to be estimated. A frequency dependent line input impedance (Zin(f)) as seen from the transmitter, is measured and an absolute impedance value (œ Zin(f) œ) is generated. The latter is shown as a curve (A1) in the diagram with the frequency (f) on the abscissa and the impedance (œ Zin(f) œ) on the ordinate. Extreme values (Max.1, Max2, Max3; Min1, Min2, Min3) arc denoted and a frequency distance (FD1-FD4) between two consecutive of the extreme values is generated. The line length (L) is generated as L=½·vop/FD1, in which vop is the velocity of propagation of a signal on the line. The attenuation is estimated by multiplying the line length with an average attenuation value for the actual line type. The advantages are that the line length can be estimated with good accuracy in a simple manner for short lines and that the line attenuation is estimated in a simple manner.

Abstract: The invention relates to a method for inhibiting the replication of herpesviruses, to methods for identifying compounds which inhibit the replication of herpesviruses using this method, to compounds having activity against herpesviruses, to methods for their preparation and to their use for producing medicaments for the treatment of herpes infections.

Abstract: This application relates to compounds of formula (I) below in which the several variable groups are as defined in the specification and claims, to methods of preparing these materials, to pharmaceutical compositions containing these materials, and to methods of using these materials to treat ischaemia or reperfusion damage.

Abstract: The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.

Abstract: The invention relates to novel amidoalkyl uracil derivatives of formula (I), to a method for the production thereof, and to their use as medicament active substances for the prophylaxis and/or treatment of medical disorders.

Abstract: The invention relates to novel compounds, to a method for the production of said compounds and to the use thereof as medicaments, more particularly as antiviral agents, especially against cytomegalovirus.

Abstract: The invention refers to single-ended test of a loop with the aid of a transceiver, wherein an input impedance (Zm(ƒ)) of the loop is generated. The transceiver has a digital part, a codec and an analog part and is connected to the loop. With the aid of a transmitted and a reflected broadband signal (vin, vout) an echo transfer function Hecho(ƒ)=V(f)out/Vin(f) is generated, which also can be expressed as H echo ? ( f ) = H ? ? ( f ) ? Z in ? ( f ) + Z h0 ? ( f ) Z in ? ( f ) + Z hyb ? ( f ) Here Zh0(ƒ), Zhyb(ƒ) and H?(ƒ) are model values for the transceiver. In a calibration process a test transceiver, with the same type of hardware as the transceiver, is connected to known impedances, replacing the loop. Hecho(ƒ)=V(f)out/Vin(f) is generated for the known impedances and the model values are generated and are stored in a memory in the transceiver.

Abstract: The invention relates to the novel compounds of formula (I), to a method for producing the same and to their use as drugs, especially as antiviral drugs.

Abstract: The invention concerns a new method for automatically and dynamically generating hierarchical topological trees of 2D- or 3D-structural formulas for structurally characterized chemical compounds, especially drug-like molecules, wherein the molecular graph of each 2D- or 3D-structure for a chemical compound is analyzed in terms of topological key features, the Largest Topological Substructure (LTS) and the proper Topological Cluster Centre (TCC) are created for each molecular graph, the ranking of the classes of topological key features and/or the ranking within each class of topological key features present in the TCC is used to generate a connected hierarchical Topological Sequence Path (TSP) of sentinel molecules from each molecular graph, and different molecular graphs and their Topological Sequence Paths (TSPs) share common vertices for common topological key features thus growing a Topological Structure Tree (TST), each chemical compound from the input stream is attached as a leaf node to the appropriate

Abstract: The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.

Abstract: Novel amidoalkyl-uracil derivatives of the formula (I) in which A represents 1-3 ring atoms and X represents optionally substituted (C2-C10)alkylene or (C3-C8)cycloalkylene as defined in claim 1, a process for their preparation, and their use as medicaments for the prophylaxis and/or treatment of disorders are described.

Abstract: Novel amidoalkyl-uracil derivatives of the formula (I) 1

Abstract: The present invention relates to thiazolylurea derivatives, a process for their preparation, and their use as pharmaceuticals, in particular as antiviral pharmaceuticals.

Abstract: The present invention relates to inhibitors of the viral helicase-primase enzyme complex with anti-herpes activity, and to medicaments containing these compounds in suitable formulation. The invention further describes a method for identifying substances with antiviral activity in order to treat herpes infections in humans and animals.

Abstract: The present invention relates to novel compounds, i.e. inverse thiazolylamide derivatives, to processes for their preparation and to their use as medicaments, in particular as antiviral medicaments.

Abstract: The present invention relates to a control circuit for an A.C. motor with two or several sets of windings. The switch-off phase of the first set of windings is symmetrical with the turn-on phase of the second set of windings, and it is illustrated how to modify the supplied current by simultaneous, symmetrical modification of said phases. As a result a symmetrical field distribution over each pole is obtained even if the turn-on and switch-off phases of the currents supplied to the windings are regulated.

Abstract: A method of stepwise speed control, and three-phase squirrel-cage motor, that comprises main windings connected either in a delta or in a star circuit, the main windings being connected to at least one set of additional windings that are also connected either in delta or in star. The method permits at least five different speeds of rotation without the use of a transformer.