Abstract: The purpose of the present invention is to provide an aqueous suspension composition comprising poorly water-soluble sirolimus or a salt thereof for ophthalmology, in particular, used for topical administration, such as a less invasive eye drop. The present invention is an ophthalmic aqueous suspension composition comprising sirolimus or a salt thereof and a surfactant, wherein the aqueous suspension composition has a pH of 4 to 6.

Abstract: A treatment method is provided which exhibits a reliable therapeutic effect on chronic obstructive pulmonary disease. In the treatment method, lung volume is reduced by restraining expansion and contraction of lung parenchyma present in the vicinity of a verge of a lung having an emphysema-suffering part, at least in one site of the verge.

Abstract: A fibrosis-causing agent is highly effective in the fibrosis of tissues. The fibrosis-causing agent contains a fibrosis inducer and a fibrosis promoter. A fibrosis-causing agent dosage form and a method of administering the fibrosis-causing agent is also disclosed.

Abstract: A flexible tube assembly according to the present disclosure includes a multiple tube having at least a first tubular member that has an elongated shape and is hollow and a second tubular member that has an elongated shape and is disposed inside the first tubular member in such a manner as to be capable of advancing and retreating relative to the first tubular member; and a hand operation unit that is provided on a proximal side of the multiple tube and operates at least the first tubular member and the second tubular member.

Abstract: A fibrosis-causing agent is highly effective in the fibrosis of tissues. The fibrosis-causing agent contains a fibrosis inducer and a fibrosis promoter. A fibrosis-causing agent dosage form and a method of administering the fibrosis-causing agent is also disclosed.

Abstract: An object of the present invention is to provide an operating member with which curving operation of a catheter distal part can be easily carried out without moving a comparatively-large member. An operating member has a rotational operation part (10) that is fixed to an elongated body (100) for medical use and rotates the elongated body for medical use about the axis, pull wires (20) fixed to the elongated body for medical use, and a pull operation part (30) that is connected to the pull wires and curves at least part of the elongated body for medical use in a direction intersecting the axial direction by pulling the pull wire.

Abstract: A flexible tube assembly according to the present disclosure includes a multiple tube having at least a first tubular member that has an elongated shape and is hollow and a second tubular member that has an elongated shape and is disposed inside the first tubular member in such a manner as to be capable of advancing and retreating relative to the first tubular member; and a hand operation unit that is provided on a proximal side of the multiple tube and operates at least the first tubular member and the second tubular member.

Abstract: An object of the present invention is to provide an operating member with which curving operation of a catheter distal part can be easily carried out without moving a comparatively-large member. An operating member has a rotational operation part (10) that is fixed to an elongated body (100) for medical use and rotates the elongated body for medical use about the axis, pull wires (20) fixed to the elongated body for medical use, and a pull operation part (30) that is connected to the pull wires and curves at least part of the elongated body for medical use in a direction intersecting the axial direction by pulling the pull wire.

Abstract: Disclosed herein is a fibrosis-causing agent in a particulate form which effectively reduces the lung capacity in a noninvasive manner.

Abstract: A treatment method is provided which exhibits a reliable therapeutic effect on chronic obstructive pulmonary disease. In the treatment method, lung volume is reduced by restraining expansion and contraction of lung parenchyma present in the vicinity of a verge of a lung having an emphysema-suffering part, at least in one site of the verge.

Abstract: A fibrosis-causing agent is highly effective in the fibrosis of tissues. The fibrosis-causing agent contains a fibrosis inducer and a fibrosis promoter. A fibrosis-causing agent dosage form and a method of administering the fibrosis-causing agent is also disclosed.