Patents by Inventor Ayman Ahmed El-Faham

Ayman Ahmed El-Faham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis and use of amino acid fluorides as peptide coupling reagents
    Patent number: 6534627
    Abstract: The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: or the acid fluoride salts thereof wherein BLK is an N-amino protecting group; AA is an amino acid residue; and X is absent or a protecting group. The amino acid fluoride is useful as a coupling agent in peptide synthesis.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: March 18, 2003
    Assignee: Research Corporation Tecnologies, Inc.
    Inventors: Louis A. Carpino, Ayman Ahmed El-Faham
  • Synthesis and use of amino acid fluorides as peptide coupling reagent
    Patent number: 6040422
    Abstract: The present invention is directed to a process for forming a peptide bond between a first amino acid having a free amino group and a protected carboxy group and a second amino acid or between a peptide having a free amino group and a blocking carboxy group with a second amino acid which comprises (a) reacting the second amino acid of the formula: ##STR1## with a fluoroformamidinium salt of the formula: ##STR2## and (b) reacting the product of (a) with the first amino acid or peptide.
    Type: Grant
    Filed: January 5, 1998
    Date of Patent: March 21, 2000
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Louis A. Carpino, Ayman Ahmed El-Faham
  • Synthesis and use of amino acid fluorides as peptide coupling reagents
    Patent number: 5750767
    Abstract: The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting groupAA is an amino acid residue andX is H or a protecting group useful,and the first amino and peptide have a free amino group and a blocked carboxy end.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 12, 1998
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Louis A. Carpino, Ayman Ahmed El-Faham
  • Synthesis and use of amino acid fluorides as peptide coupling reagents
    Patent number: 5712418
    Abstract: The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting groupAA is an amino acid residue andX is H or a protecting group useful,and the first amino and peptide have a free amino group and a blocked carboxy end.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: January 27, 1998
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Louis A. Carpino, Ayman Ahmed El-Faham