Patents by Inventor Ayyappan K. Rajasekaran

Ayyappan K. Rajasekaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210401080
    Abstract: Transparent facial masks of regenerated cellulose and other personal protective gear such as gowns, booties, surgical caps, surgical drapes, gloves and eyewear are provided.
    Type: Application
    Filed: June 28, 2021
    Publication date: December 30, 2021
    Inventor: Ayyappan K. RAJASEKARAN
  • Publication number: 20210259166
    Abstract: Weed barrier systems of one or more long lasting weed barrier sheets of flexible polymer or plant material impervious to light and water with precut holes to grow a single to more than 100 plants of different sizes and/or open ended planters which inhibit or prevent weed growth and facilitate root zone targeted water and nutrient delivery are provided.
    Type: Application
    Filed: February 24, 2021
    Publication date: August 26, 2021
    Inventor: Ayyappan K. RAJASEKARAN
  • Patent number: 10639304
    Abstract: The disclosed molecules are inhibitors of Bcr-Abl and Src kinases. The molecules are cytotoxic to Gleevec resistant cells. Inhibitors of Bcr-Abl and Src kinases are used in the treatment of Chronic Myelogenous Leukemia among other diseases.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: May 5, 2020
    Inventor: Ayyappan K. Rajasekaran
  • Publication number: 20170231975
    Abstract: The disclosed molecules are inhibitors of Bcr-Abl and Src kinases. The molecules are cytotoxic to Gleevec resistant cells. Inhibitors of Bcr-Abl and Src kinases are used in the treatment of Chronic Myelogenous Leukemia among other diseases.
    Type: Application
    Filed: May 1, 2017
    Publication date: August 17, 2017
    Inventor: Ayyappan K. Rajasekaran
  • Patent number: 9636340
    Abstract: The disclosed molecules are inhibitors of Bcr-Abl and Src kinases. The molecules are cytotoxic to Gleevec resistant cells. Inhibitors of Bcr-Abl and Src kinases are used in the treatment of Chronic Myelogenous Leukemia among other diseases.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: May 2, 2017
    Inventor: Ayyappan K. Rajasekaran
  • Publication number: 20150140071
    Abstract: The disclosed molecules are inhibitors of Bcr-Abl and Src kinases. The molecules are cytotoxic to Gleevec resistant cells. Inhibitors of Bcr-Abl and Src kinases are used in the treatment of Chronic Myelogenous Leukemia among other diseases.
    Type: Application
    Filed: November 11, 2014
    Publication date: May 21, 2015
    Inventor: Ayyappan K. Rajasekaran
  • Patent number: 7776548
    Abstract: A chimeric transmembrane protein comprising a membrane-spanning polypeptide and an internalization motif of the sequence MXXXL, where X is any amino acid. The chimeric protein can be expressed on the surface of a cell and internalized. Polynucleotides and expression vectors encoding chimeric transmembrane proteins are also provided. Expression of chimeric proteins in the plasma membrane of target cells, followed by binding of antibodies to the chimeric proteins, where the antibodies are conjugated to a cytotoxic agent, provides a means to deliver the cytotoxic agent to the inside of the target cells.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: August 17, 2010
    Assignee: The Regents of the University of California
    Inventor: Ayyappan K. Rajasekaran
  • Patent number: 5411872
    Abstract: A method for selecting transfected cell clones employs a transparent container that includes a lower-most surface that is covered with a transparent, thin sheet. The method includes the steps of: growing transfected cell clones on the transparent sheet within a growth medium in the transparent container; excising areas of the transparent sheet that support a transfected cell clone; and placing the excised transfected cell clone in a cell growth medium for further replication. The transparent sheet contained within the transparent container is provided with a peripheral adhesive area that enables it to remain in place when a transfected cell clone is excised.
    Type: Grant
    Filed: September 8, 1993
    Date of Patent: May 2, 1995
    Assignee: Cornell Research Foundation, Inc.
    Inventor: Ayyappan K. Rajasekaran
  • Patent number: 5390859
    Abstract: A method for rupturing cell walls and membranes of organic cells while leaving intra-cellular organelles substantially intact employs a culture dish for holding the cells. A pestle includes a cylindrical portion that metes with the culture dish. Extending from the cylindrical portion is an axially aligned shaft. The method includes the steps of: emplacing a layer of cells in the culture dish; placing the pestle in contact with the layer of cells; applying a pressure axially to the shaft to force the pestle into contact with the cells; and rotating the shaft and pestle a plurality of reverse-direction partial rotations to achieve a rupture of cellular membranes of cells within the culture dish. Both the base of the culture dish and the pestle are substantially planar thereby enabling uniform pressure application across the base of the culture dish.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: February 21, 1995
    Assignee: Cornell Research Foundation, Inc.
    Inventor: Ayyappan K. Rajasekaran
  • Patent number: 5384022
    Abstract: An electrophoresis system is used to segregate a molecular specimen, the apparatus comprising a container, a gel layer and a buffer solution resident in the container, the gel layer having a well for receiving the molecular specimen. Electrical contacts are resident in the container and apply a potential across the gel layer to enable migration of the molecular specimen along a migration path in the gel layer. A second well is positioned in the gel layer and downstream in the migration path. A cup is inserted into the second well, the cup having a rim which, when the cup is resident in the second well, is positioned below the migration path of the molecular specimen within the gel layer. A membrane is also placeable in the second well to prevent migration of the molecular specimen past the cup. The molecular specimen thereby migrates into the cup and is prevented by the membrane from further migration along the migration path. Aspiration of the contents of the cup enables recovery of the molecular specimen.
    Type: Grant
    Filed: September 8, 1993
    Date of Patent: January 24, 1995
    Assignee: Cornell Research Foundation, Inc.
    Inventor: Ayyappan K. Rajasekaran