Patents by Inventor Azorides Morales
Azorides Morales has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9217696Abstract: Improved methods and systems for processing of solid tissue are described. The method may be performed manually or automatically. The system may have modules such as (i) a grossing module where a fresh tissue is sliced to prepare a tissue specimen, (ii) a hardening module that hardens the tissue specimen, (iii) an impregnating module that impregnates the tissue specimen that was hardened, and (iv) an embedding module that embeds a tissue specimen that was hardened and impregnated. Fresh (i.e., not fixed or frozen) tissue, which was excised to diagnose disease or to assess surgical treatment, is grossed to about 0.6 mm. Preferably, the hardening of fresh tissue is initiated, but not completed, during grossing by contact with a chemical admixture. Preferably, dry ice, a thermoelectric device, or a gas condenser cools a metal mold containing the embedded specimen.Type: GrantFiled: September 28, 2012Date of Patent: December 22, 2015Assignee: The University of MiamiInventor: Azorides Morales
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Publication number: 20140234895Abstract: Improved methods and systems for processing of solid tissue are described. The method may be performed manually or automatically. The system may have modules such as (i) a grossing module where a fresh tissue is sliced to prepare a tissue specimen, (ii) a hardening module that hardens the tissue specimen, (iii) an impregnating module that impregnates the tissue specimen that was hardened, and (iv) an embedding module that embeds a tissue specimen that was hardened and impregnated. Fresh (i.e., not fixed or frozen) tissue, which was excised to diagnose disease or to assess surgical treatment, is grossed to about 0.6 mm Preferably, the hardening of fresh tissue is initiated, but not completed, during grossing by contact with a chemical admixture. Preferably, dry ice, a thermoelectric device, or a gas condenser cools a metal mold containing the embedded specimen.Type: ApplicationFiled: September 28, 2012Publication date: August 21, 2014Inventor: Azorides Morales
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Patent number: 8221996Abstract: A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid and continuous processing is accomplished by decreasing the thickness of tissue sections, use of non-aqueous solutions composed of admixtures of solutions, solution exchange at elevated temperature and with agitation, and impregnation under vacuum pressure. The patient in surgery is thus provided with point-of-care surgical pathology.Type: GrantFiled: March 12, 2008Date of Patent: July 17, 2012Assignee: The University of MiamiInventors: Azorides Morales, Harold Essenfeld, Ervin Essenfeld
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Patent number: 7547538Abstract: A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid and continuous processing is accomplished by decreasing the thickness of tissue sections, use of nonaqueous solutions composed of admixtures of solutions, solution exchange at elevated temperature and with agitation, and impregnation under vacuum pressure. The patient in surgery is thus provided with point-of-care surgical pathology.Type: GrantFiled: March 27, 2003Date of Patent: June 16, 2009Assignee: The University of MiamiInventors: Azorides Morales, Harold Essenfeld, Ervin Essenfeld
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Publication number: 20080153127Abstract: A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid and continuous processing is accomplished by decreasing the thickness of tissue sections, use of non-aqueous solutions composed of admixtures of solutions, solution exchange at elevated temperature and with agitation, and impregnation under vacuum pressure. The patient in surgery is thus provided with point-of-care surgical pathology.Type: ApplicationFiled: March 12, 2008Publication date: June 26, 2008Applicant: University of MiamiInventors: Azorides MORALES, Harold Essenfeld, Ervin Essenfeld
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Publication number: 20070186736Abstract: A tool for holding tissue to be sampled in place to allow tissue samples of a prescribed thickness to be prepared from the held tissue. The tool includes at least one tine array for engaging and holding the tissue. First and second tine arrays may advantageously be provided to define a slice thickness therebetween. In addition, or in the alternative, the tines of the tine array are mutually spaced apart by different distances to effectively hold the tissue and to define prescribed tissue sample lengths.Type: ApplicationFiled: April 12, 2007Publication date: August 16, 2007Applicant: The University of MiamiInventor: Azorides Morales
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Publication number: 20050090017Abstract: Improved systems and methods for tissue processing are described here. The chemical process and the construction of the apparatus are simplified by using only two different solutions in two separate reaction modules. They are compatible with processing of tissue specimens for genetic analysis, histology, in situ antibody binding and hybridization, archival preservation of morphology and nucleic acids, and combinations thereof.Type: ApplicationFiled: October 25, 2004Publication date: April 28, 2005Inventor: Azorides Morales
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Publication number: 20040004075Abstract: A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid and continuous processing is accomplished by decreasing the thickness of tissue sections, use of nonaqueous solutions composed of admixtures of solutions, solution exchange at elevated temperature and with agitation, and impregnation under vacuum pressure. The patient in surgery is thus provided with point-of-care surgical pathology.Type: ApplicationFiled: March 27, 2003Publication date: January 8, 2004Applicants: The University of Miami, Harold Essenfeld, Ervin EssenfeldInventors: Azorides Morales, Harold Essenfeld, Ervin Essenfeld
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Patent number: 6586713Abstract: A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid and continuous processing is accomplished by decreasing the thickness of tissue sections, use of non-aqueous solutions composed of admixtures of solutions, solution exchange at elevated temperature and with agitation, and impregnation under vacuum pressure. The patient in surgery is thus provided with point-of-care surgical pathology.Type: GrantFiled: December 15, 2000Date of Patent: July 1, 2003Assignee: The University of MiamiInventors: Ervin Essenfeld, Harold Essenfeld, Azorides Morales
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Publication number: 20020020276Abstract: A grossing board for preparing gross tissue samples having relatively uniform thickness features one or more tissue-receiving depressions and one or more knife-guiding members. The bottom surface of a tissue-receiving depression is essentially parallel to the upper, cutting surface of the grossing board, and the knife-guiding members are configured to guide the pathologist's knife so as to ensure cuts that are parallel to the bottom surface of the tissue-receiving depression, thereby yielding gross tissue samples of desired reproducible, uniform thickness.Type: ApplicationFiled: June 8, 2001Publication date: February 21, 2002Inventors: Azorides Morales, Ervin Essenfeld, Harold Essenfeld
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Publication number: 20010000487Abstract: A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid and continuous processing is accomplished by decreasing the thickness of tissue sections, use of non-aqueous solutions composed of admixtures of solutions, solution exchange at elevated temperature and with agitation, and impregnation under vacuum pressure. The patient in surgery is thus provided with point-of-care surgical pathology.Type: ApplicationFiled: December 15, 2000Publication date: April 26, 2001Applicant: The University of MiamiInventors: Ervin Essenfeld, Harold Essenfeld, Azorides Morales
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Patent number: 6207408Abstract: A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid and continuous processing is accomplished by decreasing the thickness of tissue sections, use of non-aqueous solutions composed of admixtures of solutions, solution exchange at elevated temperature and with agitation, and impregnation under vacuum pressure. The patient in surgery is thus provided with point-of-care surgical pathology.Type: GrantFiled: August 19, 1998Date of Patent: March 27, 2001Assignee: University of MiamiInventors: Ervin Essenfeld, Harold Essenfeld, Azorides Morales