Patents by Inventor Bahram A. Parvin

Bahram A. Parvin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200318165
    Abstract: Methods of labeling, identifying and differentiating microorganisms using functionalized Buckyballs are provided herein. The invention further provides methods for imaging or inhibiting gene expression using functionalized Buckyballs of the invention. The invention also provides a system for labeling, identifying and differentiating microorganisms.
    Type: Application
    Filed: April 21, 2020
    Publication date: October 8, 2020
    Inventors: Bahram Parvin, Qingsu Cheng
  • Patent number: 10776606
    Abstract: Embodiments disclosed herein provide methods and systems for delineating cell nuclei and classifying regions of histopathology or microanatomy while remaining invariant to batch effects. These systems and methods can include providing a plurality of reference images of histology sections. A first set of basis functions can then be determined from the reference images. Then, the histopathology or microanatomy of the histology sections can be classified by reference to the first set of basis functions, or reference to human engineered features. A second set of basis functions can then be calculated for delineating cell nuclei from the reference images and delineating the nuclear regions of the histology sections based on the second set of basis functions.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: September 15, 2020
    Assignee: The Regents of the University of California
    Inventors: Bahram Parvin, Hang Chang, Yin Zhou
  • Patent number: 10626469
    Abstract: Methods of labeling, identifying and differentiating microorganisms using functionalized Buckyballs are provided herein. The invention further provides methods for imaging or inhibiting gene expression using functionalized Buckyballs of the invention. The invention also provides a system for labeling, identifying and differentiating microorganisms.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: April 21, 2020
    Assignee: Board of Regents of the Nevada System of Higher Education, on behalf of the University of Nevada, Reno
    Inventors: Bahram Parvin, Qingsu Cheng
  • Publication number: 20180291432
    Abstract: Methods of labeling, identifying and differentiating microorganisms using functionalized Buckyballs are provided herein. The invention further provides methods for imaging or inhibiting gene expression using functionalized Buckyballs of the invention. The invention also provides a system for labeling, identifying and differentiating microorganisms.
    Type: Application
    Filed: September 2, 2016
    Publication date: October 11, 2018
    Inventors: Bahram Parvin, Qingsu Cheng
  • Patent number: 9816066
    Abstract: The introduction of tools to study, control or expand the inner-workings of algae has been slow to develop. Provided are embodiments of a molecular method based on guanidinium-rich molecular transporters (GR-MoTrs) for bringing molecular cargos into algal cells. The methods of the disclosure have been shown to work in wild-type algae that have an intact cell wall. Developed using Chlamydomonas reinhardtii, this method is also successful with less studied algae, including Neochloris oleoabundans and Scenedesmus dimorphus, thus providing a new and versatile tool for algal research and modification. The method of delivering a cargo compound to an algal cell comprises contacting an algal cell with a guanidinium-rich delivery vehicle comprising a guanidinium-rich molecular transporter (GR-MoTr) linked to a cargo compound desired to be delivered to the algal cell, whereby the guanidinium-rich molecular transporter can traverse the algal cell wall, thereby delivering the cargo compound to the algal cell.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: November 14, 2017
    Assignees: The Regents of the University of California, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Erika Geihe, Brian Trantow, Paul Wender, Joel M. Hyman, Bahram Parvin
  • Patent number: 9031306
    Abstract: Determining at least one of a prognosis or a therapy for a patient based on a stained tissue section of the patient. An image of a stained tissue section of a patient is processed by a processing device. A set of features values for a set of cell-based features is extracted from the processed image, and the processed image is associated with a particular cluster of a plurality of clusters based on the set of feature values, where the plurality of clusters is defined with respect to a feature space corresponding to the set of features.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: May 12, 2015
    Assignee: The Regents of the University of California
    Inventors: Bahram Parvin, Hang Chang, Ju Han, Gerald V. Fontenay
  • Publication number: 20150118704
    Abstract: The introduction of tools to study, control or expand the inner-workings of algae has been slow to develop. Provided are embodiments of a molecular method based on guanidinium-rich molecular transporters (GR-MoTrs) for bringing molecular cargos into algal cells. The methods of the disclosure have been shown to work in wild-type algae that have an intact cell wall. Developed using Chlamydomonas reinhardtii, this method is also successful with less studied algae, including Neochloris oleoabundans and Scenedesmus dimorphus, thus providing a new and versatile tool for algal research and modification. The method of delivering a cargo compound to an algal cell comprises contacting an algal cell with a guanidinium-rich delivery vehicle comprising a guanidinium-rich molecular transporter (GR-MoTr) linked to a cargo compound desired to be delivered to the algal cell, whereby the guanidinium-rich molecular transporter can traverse the algal cell wall, thereby delivering the cargo compound to the algal cell.
    Type: Application
    Filed: March 12, 2013
    Publication date: April 30, 2015
    Inventors: Erika Geihe, Brian Trantow, Paul Wender, Joel M. Hyman, Bahram Parvin
  • Publication number: 20150110381
    Abstract: Embodiments disclosed herein provide methods and systems for delineating cell nuclei and classifying regions of histopathology or microanatomy while remaining invariant to batch effects. These systems and methods can include providing a plurality of reference images of histology sections. A first set of basis functions can then be determined from the reference images. Then, the histopathology or microanatomy of the histology sections can be classified by reference to the first set of basis functions, or reference to human engineered features. A second set of basis functions can then be calculated for delineating cell nuclei from the reference images and delineating the nuclear regions of the histology sections based on the second set of basis functions.
    Type: Application
    Filed: September 22, 2014
    Publication date: April 23, 2015
    Inventors: Bahram Parvin, Hang Chang, Yin Zhou
  • Publication number: 20140072955
    Abstract: The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time; quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells.
    Type: Application
    Filed: September 16, 2013
    Publication date: March 13, 2014
    Inventors: Daniel E. Callahan, Bahram Parvin
  • Publication number: 20130294676
    Abstract: Determining at least one of a prognosis or a therapy for a patient based on a stained tissue section of the patient. An image of a stained tissue section of a patient is processed by a processing device. A set of features values for a set of cell-based features is extracted from the processed image, and the processed image is associated with a particular cluster of a plurality of clusters based on the set of feature values, where the plurality of clusters is defined with respect to a feature space corresponding to the set of features.
    Type: Application
    Filed: May 2, 2013
    Publication date: November 7, 2013
    Applicant: The Regents of the University of California
    Inventors: Bahram Parvin, Hang Chang, Ju Han, Gerald V. Fontenay
  • Patent number: 8548745
    Abstract: The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time; quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: October 1, 2013
    Assignee: The Regents of the University of California
    Inventors: Daniel E. Callahan, Bahram Parvin
  • Publication number: 20110216953
    Abstract: The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time; quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells.
    Type: Application
    Filed: May 13, 2011
    Publication date: September 8, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Daniel E. Callahan, Bahram Parvin
  • Patent number: 7949474
    Abstract: The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time; quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: May 24, 2011
    Assignee: The Regents of the University of California
    Inventors: Daniel E. Callahan, Bahram Parvin
  • Publication number: 20090285469
    Abstract: The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time; quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells.
    Type: Application
    Filed: June 3, 2009
    Publication date: November 19, 2009
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Daniel E. Callahan, Bahram Parvin
  • Patent number: 7546210
    Abstract: The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time: quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: June 9, 2009
    Assignee: The Regents of the University of California
    Inventors: Daniel E. Callahan, Bahram Parvin
  • Publication number: 20040029213
    Abstract: The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time: quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells.
    Type: Application
    Filed: June 26, 2003
    Publication date: February 12, 2004
    Inventors: Daniel E. Callahan, Bahram Parvin
  • Patent number: 5671086
    Abstract: An apparatus using electrophoresis provides accurate manipulation of an object on a microscope stage for further manipulations add reactions. The present invention also provides an inexpensive and easily accessible means to move an object without damage to the object. A plurality of electrodes are coupled to the stage in an array whereby the electrode array allows for distinct manipulations of the electric field for accurate manipulations of the object. There is an electrode array control coupled to the plurality of electrodes for manipulating the electric field. In an alternative embodiment, a chamber is provided on the stage to hold the object. The plurality of electrodes are positioned in the chamber, and the chamber is filled with fluid. The system can be automated using visual servoing, which manipulates the control parameters, i.e., x, y stage, applying the field, etc., after extracting the significant features directly from image data.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: September 23, 1997
    Assignee: The Regents, University of California
    Inventors: Bahram A. Parvin, Marcos F. Maestre, Richard H. Fish, William E. Johnston
  • Patent number: 4845610
    Abstract: A method for determining whether a perceived target is acceptably close to a model target. The perceived target is first segmented using a relaxation based procedure. Structural features from the perceived target are extracted by producing a compact one-dimensional description of the perceived target's boundary. Said structural features are classified by using string-to-string matching, wherein one of two symbolic strings is a representation of the compact one-dimensional description of the boundary of the perceived target, and the other of said two symbolic strings is a pre-stored representation of the model target. The string-to-string matching entails measuring the distance between the two strings based upon deletion, insertion, and substitution of symbols from one string to the other. Performing the string-to-string matching measures how closely local structural features of the perceived target resemble local structural features of the model target.
    Type: Grant
    Filed: March 13, 1987
    Date of Patent: July 4, 1989
    Assignee: Ford Aerospace & Communications Corporation
    Inventor: Bahram A. Parvin
  • Patent number: 4698751
    Abstract: A systolic array (1) for reducing the time required to solve an algorithm having cyclic loop dependency, i.e., nested loops in which values calculated by inner loops depend upon indices of said inner loops and upon indices of outer loops. The array (1) comprises a chain of several identical serially connected and sequentially accessed cells. In the preferred embodiment, each cell, except for first and last cells in the chain, is connected to its two adjacent cells only. Multiprocessing is employed: at certain times during the algorithm solving, more than one cell is simultaneously activated to perform portions of the solving, so that the total time required to solve the algorithms is shortened to be a linear function of n.times.m. The algorithm can represent measurement of the distance between two symbolic strings, or other problems in artificial intelligence or logic.
    Type: Grant
    Filed: July 13, 1984
    Date of Patent: October 6, 1987
    Assignee: Ford Aerospace & Communications Corporation
    Inventor: Bahram A. Parvin