Patents by Inventor Balász Sarkadi

Balász Sarkadi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay and reagent kit for evaluation of multi-drug resistance in cells
    Patent number: 6391656
    Abstract: Disclosed herein are methods and reagent kits for the quantitative in vitro determination of the functional determination of multi-drug resistance in cells, as well as for the clinical screening of potential modulators of multi-drug resistant transport activity in cells. The method of the invention is based on the measurement of the accumulation rate of free calcein within the cells of the specimen (advantageously by fluorescence measurement), after exposing the cells in vitro to a cell permeable form of calcein that is a good substrate for MDR proteins present in the sample. The cell permeable form of calcein is converted within the cell by intracellular enzymes to free calcein. Comparison of free calcein accumulation in the presence and absence of a potential inhibitor of transport activity permits the rapid screening of such inhibitors.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: May 21, 2002
    Assignee: SOLVO Biotechnology
    Inventors: Balász Sarkadi, László Homolya, Zsolt Holló
  • Assay and reagent kit for evaluation of multi-drug resistance in cells
    Publication number: 20010019846
    Abstract: Disclosed herein are methods and reagent kits for the quantitative in vitro determination of the functional determination of multi-drug resistance in cells, as well as for the clinical screening of potential modulators of multi-drug resistant transport activity in cells
    Type: Application
    Filed: April 23, 2001
    Publication date: September 6, 2001
    Applicant: SOLVO Biotechnology
    Inventors: Balasz Sarkadi, Laszlo Homolya, Zsolt Hollo