Patents by Inventor Balasingam Rhadakrishnan

Balasingam Rhadakrishnan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enkephalin conjugates
    Patent number: 6956051
    Abstract: The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugates comprise a therapeutic compound conjugated to an oligomer, wherein the oligomer comprises a lipophilic moiety coupled to a hydrophilic moiety. The conjugates of the invention further comprise therapeutic agents such as proteins, peptides, nucleosides, nucleotides, antiviral agents, antineoplastic agents, antibiotics, etc., and prodrugs, precursors, derivatives and intermediates thereof, chemically coupled to amphiphilic oligomers.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: October 18, 2005
    Assignee: Nobex Corporation
    Inventors: Nnochiri N. Ekwuribe, Balasingam Rhadakrishnan, Christopher H. Price, Wes Anderson Jr., Aslam M. Ansari
  • Methods for delivering therapeutics across blood-barrier and for altering receptor binding affinity
    Patent number: 6943148
    Abstract: The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugates comprise a therapeutic compound conjugated to an oligomer, wherein the oligomer comprises a lipophilic moiety coupled to a hydrophilic moiety. The conjugates of the invention further comprise therapeutic agents such as proteins, peptides, nucleosides, nucleotides, antiviral agents, antineoplastic agents, antibiotics, etc., and prodrugs, precursors, derivatives and intermediates thereof, chemically coupled to amphiphilic oligomers.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: September 13, 2005
    Assignee: Nobex Corporation
    Inventors: Nnochiri N. Ekwuribe, Balasingam Rhadakrishnan, Christopher H. Price, Wes Anderson Jr., Adam M. Ansari
  • Methods for delivery therapeutic compounds across the blood-brain barrier
    Patent number: 6703381
    Abstract: The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugates comprise a therapeutic compound conjugated to an oligomer, wherein the oligomer comprises a lipophilic moiety coupled to a hydrophilic moiety. The conjugates of the invention further comprise therapeutic agents such as proteins, peptides, nucleosides, nucleotides, antiviral agents, antineoplastic agents, antibiotics, etc., and prodrugs, precursors, derivatives and intermediates thereof, chemically coupled to amphiphilic oligomers.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: March 9, 2004
    Assignee: Nobex Corporation
    Inventors: Nnochiri N. Ekwuribe, Balasingam Rhadakrishnan, Christopher H. Price, Wes Anderson, Jr., Aslam M. Ansari