Patents by Inventor Balbir Raj
Balbir Raj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220187325Abstract: The present invention provides assay devices and methods for detecting the presence of an analyte in a sample. Devices according to the invention include a reagent zone, one or more capture zones and a detection zone. Capture zones can reduce the quantity of labelled conjugate that reaches the detection zone in the presence of a negative marker in the sample and/or in the absence of a positive marker in the sample, facilitating high sensitivity and improved specificity testing.Type: ApplicationFiled: April 9, 2020Publication date: June 16, 2022Inventors: Catherine Ungeprapakom, Stephen Carlisle, Balbir Raj
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Patent number: 9638704Abstract: The present invention relates generally to an assay device with improved tolerance to mishandling and/or use by the user. More particularly, the invention relates to an assay device with reduced susceptibility to flooding.Type: GrantFiled: November 24, 2011Date of Patent: May 2, 2017Assignee: SPD SWISS PRECISION DIAGNOSTICS GMBHInventors: Balbir Raj, Saji Eapen, Ian Scrimgeour
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Patent number: 9151749Abstract: Disclosed is a method for determining the presence and/or amount Oran analyte of interest in a liquid sample comprising the steps of: contacting the liquid sample suspected of containing analyte with a gas generating means (eg. catalase and peracid or peroxygen compound), which gas generating means forms a gas dependent upon the presence, absence or amount of analyte, which gas creates one or more bubbles in the liquid sample which act to alter the flow of liquid along a flow path; and determining an alteration of flow in the liquid wherein the alteration of flow of liquid along the flow path is indicative of the presence and/or amount of analyte in the liquid sample.Type: GrantFiled: April 9, 2009Date of Patent: October 6, 2015Assignees: Alere Switzerland GMBH, SPD Swiss Precision Diagnostics GMBHInventor: Balbir Raj
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Patent number: 8721990Abstract: Disclosed is an assay device for the determination of the presence and/or extent if an analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilizing a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilizing a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.Type: GrantFiled: April 9, 2008Date of Patent: May 13, 2014Assignee: Alere Switzerland GmbHInventors: Balbir Raj, Saji Eapen, Ezra Linley
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Publication number: 20130309760Abstract: The present invention relates generally to an assay device with improved tolerance to mishandling and/or use by the user. More particularly, the invention relates to an assay device with reduced susceptibility to flooding.Type: ApplicationFiled: November 24, 2011Publication date: November 21, 2013Applicant: SPD SwissPrecicion Diagnostics GmbHInventors: Balbir Raj, Saji Eapen, Ian Scrimgeour
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Publication number: 20120201720Abstract: Disclosed is an assay device for the determination of analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilising a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilising a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.Type: ApplicationFiled: December 6, 2011Publication date: August 9, 2012Applicant: SPD Swiss Precision Diagnostics GmbHInventors: Balbir Raj, Ezra Linley, Saji Eapen
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Publication number: 20110300555Abstract: Disclosed is a method for determining the presence and/or amount Oran analyte of interest in a liquid sample comprising the steps of: contacting the liquid sample suspected of containing analyte with a gas generating means (eg. catalase and peracid or peroxygen compound), which gas generating means forms a gas dependent upon the presence, absence or amount of analyte, which gas creates one or more bubbles in the liquid sample which act to alter the flow of liquid along a flow path; and determining an alteration of flow in the liquid wherein the alteration of flow of liquid along the flow path is indicative of the presence and/or amount of analyte in the liquid sample.Type: ApplicationFiled: April 9, 2009Publication date: December 8, 2011Inventors: Balbir Raj, David Tolley
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Publication number: 20110223690Abstract: The present invention provides an assay kit for detecting an analyte of interest in a sample. The kit comprises a) a reporter species; b) a labelled species having first and second binding regions, wherein the first binding region is capable of binding to the analyte of interest and the second binding region is capable of binding to the reporter species; c) an immobilised species capable of binding to the first binding region of the labelled species; and d) immobilised capture reagent capable of binding to the reporter species. The arrangement is such that the sample is contacted with the labelled species, is then contacted with the immobilised species and is subsequently contacted with the immobilised capture reagent, the reporter species being added prior to exposure of the sample to the immobilised capture reagent. If no analyte is present in the sample, the labelled species becomes bound to the immobilised species and is therefore unable to bind to the immobilised capture reagent.Type: ApplicationFiled: February 1, 2011Publication date: September 15, 2011Inventor: Balbir Raj
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Patent number: 7901949Abstract: The present invention provides an assay kit for detecting an analyte of interest in a sample. The kit comprises a) a reporter species; b) a labelled species having first and second binding regions, wherein the first binding region is capable of binding to the analyte of interest and the second binding region is capable of binding to the reporter species; c) an immobilised species capable of binding to the first binding region of the labelled species; and d) immobilised capture reagent capable of binding to the reporter species. The arrangement is such that the sample is contacted with the labelled species, is then contacted with the immobilised species and is subsequently contacted with the immobilised capture reagent, the reporter species being added prior to exposure of the sample to the immobilised capture reagent. If no analyte is present in the sample, the labelled species becomes bound to the immobilised species and is therefore unable to bind to the immobilised capture reagent.Type: GrantFiled: June 12, 2006Date of Patent: March 8, 2011Assignee: Alere Switzerland GmbHInventor: Balbir Raj
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Publication number: 20100320237Abstract: One embodiment is a dispensing apparatus including a dispensing head for a fluid, wherein the dispensing head comprises an actuator, a pump mechanism and a locking member. The actuator is movable relative to the pump mechanism from a lock position to a first pump position and moveable relative to the pump mechanism between a first pump position and a second pump position for actuating said pump mechanism. The dispensing apparatus is configurable into a locked configuration, in which the actuator is in the lock position and in which the locking member is braced between the actuator and the pump mechanism to prevent movement of the actuator from the lock position, and an unlocked configuration in which the locking member allows movement of the actuator from the lock position, and wherein the dispensing head is adapted to revert from the unlocked configuration when the actuator is returned to the lock position.Type: ApplicationFiled: June 17, 2009Publication date: December 23, 2010Applicant: ACCREDIT INNOVATIONS LIMITEDInventors: Balbir Raj, Matthew Rose
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Publication number: 20100209297Abstract: Disclosed is an assay device for the determination of the presence and/or extent if an analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilising a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilising a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.Type: ApplicationFiled: April 9, 2008Publication date: August 19, 2010Applicant: Inverness Medical Switzerland GmbHInventors: Balbir Raj, Saji Eapen, Ezra Linley
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Publication number: 20090196792Abstract: Disclosed is an assay device for the determination of analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilising a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilising a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.Type: ApplicationFiled: September 2, 2008Publication date: August 6, 2009Applicant: Inverness Medical Switzerland GmbHInventors: Balbir Raj, Ezra Linley, Saji Eapen
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Publication number: 20080118398Abstract: Provided are assay devices comprising sample-activatable battery cells.Type: ApplicationFiled: October 5, 2007Publication date: May 22, 2008Applicant: Inverness Medical Switzerland GmbHInventors: Brian J. Birch, Balbir Raj
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Publication number: 20080020482Abstract: An assay device may include a housing, at least partially within which is housed a test strip. The housing may define a test window through which a test zone of the test strip may be viewed. The device may include a movable portion which is movable between first (“testing”) and second (“reading”) positions such that, at the first position the movable portion covers the test window, thereby obscuring the test zone, and such that movement of the movable portion from the first position to the second position uncovers or reveals the test zone, rendering the test zone available for visual inspection. The movable portion may include a visual indicator which can be positioned, by movement of the movable portion, so as to be apparent in the test window to a user viewing the test result.Type: ApplicationFiled: June 8, 2005Publication date: January 24, 2008Inventor: Balbir Raj
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Publication number: 20070015290Abstract: The present invention provides an assay kit for detecting an analyte of interest in a sample. The kit comprises a) a reporter species; b) a labelled species having first and second binding regions, wherein the first binding region is capable of binding to the analyte of interest and the second binding region is capable of binding to the reporter species; c) an immobilised species capable of binding to the first binding region of the labelled species; and d) immobilised capture reagent capable of binding to the reporter species. The arrangement is such that the sample is contacted with the labelled species, is then contacted with the immobilised species and is subsequently contacted with the immobilised capture reagent, the reporter species being added prior to exposure of the sample to the immobilised capture reagent. If no analyte is present in the sample, the labelled species becomes bound to the immobilised species and is therefore unable to bind to the immobilised capture reagent.Type: ApplicationFiled: June 12, 2006Publication date: January 18, 2007Inventor: Balbir Raj
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Patent number: 6523691Abstract: A child-resistant unit does holder includes a blister pack having a plurality of protrusions formed in a sheet and a unit dose disposed in each of the protrusions. The pack is slidably received in a sleeve which covers the protrusions to prevent a unit dose being dispensed from the pack. A releasable detent mechanism prevents slidable removal of the pack from the sleeve, and at least one of the protrusions forms a detent of the detent mechanism.Type: GrantFiled: April 6, 2001Date of Patent: February 25, 2003Inventors: Balbir Raj, Ian Jobling, Gurmej Kaur
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Publication number: 20010017273Abstract: A child-resistant unit does holder includes a blister pack having a plurality of protrusions formed in a sheet and a unit dose disposed in each of the protrusions. The pack is slidably received in a sleeve which covers the protrusions to prevent a unit dose being dispensed from the pack. A releasable detent mechanism prevents slidable removal of the pack from the sleeve, and at least one of the protrusions forms a detent of the detent mechanism.Type: ApplicationFiled: April 6, 2001Publication date: August 30, 2001Inventors: Balbir Raj, Ian Jobling, Gurmej Kaur