Abstract: A conjugate compounds or pharmaceutically acceptable salt thereof, comprises a payload and two or more kinds of cell-interacting molecules. The cell-interacting molecules are ligands capable of specifically binding to a cell surface receptor. A method of treating diseases, comprises delivering a payload to a subject.

Abstract: The present application provides a seafloor multi-wave seismic source including: a pressure chamber mechanism; a high-voltage pulse generator with four discharge pathways; a thrust mechanism with a thrust rod and a thrust head; four vibrators are evenly distributed around a periphery of the thrust head, and each vibrator is connected with one discharge pathway of the high-voltage pulse generator; a power supply unit to power the seismic source; and a processor, a memory and a program, wherein the program is stored in the memory and configured to be executed by the processor; and the program includes: pulse emission instructions generated by the processor based on user settings and received by the high-voltage pulse generator, for switching on four or any two of the four discharge pathways at the same time, to enable the corresponding vibrators to vibrate to excite seismic waves in compression wave mode or shear wave mode.

Abstract: The present invention discloses a new submerged buoy data acquisition system, including a battery compartment, a main control processor, a GPS receiver, a gigabit Ethernet interface module, and a plurality of data acquisition boards, where the GPS receiver is connected to the main control processor, and the main control processor is connected to a host computer by using the gigabit Ethernet interface module; the data acquisition board includes a hydrophone sensor, a front-end drive circuit, an AD conversion circuit, a clock module, a DA conversion circuit, an FPGA, an ARM processor, and a storage module; the hydrophone sensor is connected to the AD conversion circuit by using the front-end drive circuit, the AD conversion circuit is connected to the FPGA, the FPGA is connected to the ARM processor, the storage module is connected to the ARM processor, the DA conversion circuit is connected to the FPGA and the clock module, the clock module is connected to the FPGA, and the ARM processor is connected to the ma

Abstract: The present application provides a seafloor multi-wave seismic source including: a pressure chamber mechanism; a high-voltage pulse generator with four discharge pathways; a thrust mechanism with a thrust rod and a thrust head; four vibrators are evenly distributed around a periphery of the thrust head, and each vibrator is connected with one discharge pathway of the high-voltage pulse generator; a power supply unit to power the seismic source; and a processor, a memory and a program, wherein the program is stored in the memory and configured to be executed by the processor; and the program includes: pulse emission instructions generated by the processor based on user settings and received by the high-voltage pulse generator, for switching on four or any two of the four discharge pathways at the same time, to enable the corresponding vibrators to vibrate to excite seismic waves in compression wave mode or shear wave mode.

Abstract: The present invention provides an agent that enables Sirt7 gene expression, especially a recombinant adeno-associated virus (rAAV) that enables vascular endothelium (VE)-specific Sirt7 gene expression, and the use thereof. The present invention also provides a method for improving neovascularization, ameliorating aging features, extending lifespan and treating age-related diseases by using the agent, especially the rAAV.

Abstract: The present invention discloses a submarine seismic monitoring apparatus and system based on the submarine Internet of things.

Abstract: Provided are a connection structure and system of an integrated brake device for a rail vehicle. The connection structure of an integrated brake device for a rail vehicle includes a brake valve, a dust collector, an intermediate body, an air cylinder, a support assembly and a connection assembly. The intermediate body is of a plate-type structure, the brake valve and the dust collector are mounted on one side of the intermediate body, the air cylinder is connected to the intermediate body by means of the connection assembly, the air cylinder is mounted on the other side of the intermediate body, and the support assembly is located between the air cylinder and the intermediate body. The connection structure of an integrated brake device for a rail vehicle has a simple and compact structure and saves on space.

Abstract: Use of endothelial progenitor cells in the manufacture of a medicament for rejuvenating neovascularization capacity, ameliorating aging features, preventing aging, extending lifespan, and/or treating progeria and/or age-related diseases. A method for rejuvenating neovascularization capacity, ameliorating aging features, preventing aging, extending lifespan, and/or treating progeria and/or age-related diseases, includes: administering a pharmaceutically effective amount of EPCs to a subject in need thereof.

Abstract: The present invention discloses a near-sea-bottom hydrate detection system, which includes a ship-borne part and a deep-towing part. The ship-borne part includes: a comprehensive monitoring host, configured to send an acquisition triggering pulse signal, and transmit the signal to the deep-towing part; and receive near-sea-bottom information acquired by the deep-towing part, and determine a near-sea-bottom condition according to the near-sea-bottom information.

Abstract: A method and device for publishing at least one message and a storage medium is provided. The method includes the following steps. A first message published by a first session account in a first session of an instant messaging client is acquired, and session accounts participating in the first session include at least three session accounts containing the first session account, and the first message is used for allowing reply information of at least one reply of at least one session account participating in the first session to the first message to be displayed in the first message. And the first message is displayed in the first session.

Abstract: Seismic exploration system based on an underwater mobile platform including: an add-on type electronic cabin, a circuit integration device, an underwater mobile platform, a mounting mechanism, a multi-electrode emission array, and a multi-channel hydrophone linear array; where the electronic cabin is externally fixed on the underwater mobile platform through the mounting mechanism, the circuit integration device is disposed in the electronic cabin, the circuit integration device is connected with the multi-electrode emission array, and the multi-electrode emission array is connected with the multi-channel hydrophone linear array; and the circuit integration device includes a multi-channel underwater acoustic data acquisition device, a sound source host, a photoelectric junction box and a battery pack, where the acoustic data acquisition device is connected with the sound source host, and the photoelectric junction box is connected with the acoustic data acquisition device, the sound source host, the battery p

Abstract: The present invention discloses a near-sea-bottom hydrate detection system, which includes a ship-borne part and a deep-towing part. The ship-borne part includes: a comprehensive monitoring host, configured to send an acquisition triggering pulse signal, and transmit the signal to the deep-towing part; and receive near-sea-bottom information acquired by the deep-towing part, and determine a near-sea-bottom condition according to the near-sea-bottom information.

Abstract: The present invention discloses a new submerged buoy data acquisition system, including a battery compartment, a main control processor, a GPS receiver, a gigabit Ethernet interface module, and a plurality of data acquisition boards, where the GPS receiver is connected to the main control processor, and the main control processor is connected to a host computer by using the gigabit Ethernet interface module; the data acquisition board includes a hydrophone sensor, a front-end drive circuit, an AD conversion circuit, a clock module, a DA conversion circuit, an FPGA, an ARM processor, and a storage module; the hydrophone sensor is connected to the AD conversion circuit by using the front-end drive circuit, the AD conversion circuit is connected to the FPGA, the FPGA is connected to the ARM processor, the storage module is connected to the ARM processor, the DA conversion circuit is connected to the FPGA and the clock module, the clock module is connected to the FPGA, and the ARM processor is connected to the ma

Abstract: Provided are a connection structure and system of an integrated brake device for a rail vehicle. The connection structure of an integrated brake device for a rail vehicle includes a brake valve, a dust collector, an intermediate body, an air cylinder, a support assembly and a connection assembly. The intermediate body is of a plate-type structure, the brake valve and the dust collector are mounted on one side of the intermediate body, the air cylinder is connected to the intermediate body by means of the connection assembly, the air cylinder is mounted on the other side of the intermediate body, and the support assembly is located between the air cylinder and the intermediate body. The connection structure of an integrated brake device for a rail vehicle has a simple and compact structure and saves on space.

Abstract: The present invention discloses a submarine seismic monitoring apparatus and system based on the submarine Internet of things.

Abstract: Seismic exploration system based on an underwater mobile platform including: an add-on type electronic cabin, a circuit integration device, an underwater mobile platform, a mounting mechanism, a multi-electrode emission array, and a multi-channel hydrophone linear array; where the electronic cabin is externally fixed on the underwater mobile platform through the mounting mechanism, the circuit integration device is disposed in the electronic cabin, the circuit integration device is connected with the multi-electrode emission array, and the multi-electrode emission array is connected with the multi-channel hydrophone linear array; and the circuit integration device includes a multi-channel underwater acoustic data acquisition device, a sound source host, a photoelectric junction box and a battery pack, where the acoustic data acquisition device is connected with the sound source host, and the photoelectric junction box is connected with the acoustic data acquisition device, the sound source host, the battery p

Abstract: A marine magnetism detection device and a detection method are provided. The device includes a surveying ship, an onboard laboratory magnetism measurement portion arranged on the surveying ship, an aerostat shell and an aerostat magnetism measurement portion arranged inside the aerostat shell. The aerostat shell is connected to the surveying ship via a rope, and the aerostat shell floats in air. The aerostat magnetism measurement portion includes a magnetic sensor, an electronic magnetism data acquisition unit and an aerostat transmission unit; and the onboard laboratory magnetism measurement portion includes a data recording computer and a laboratory transmission unit. The marine magnetism detection device and method of the present invention are advantageously not limited by the working sea area and can also operate with other onboard devices and dragging devices.

Abstract: The present invention discloses a marine magnetism detection device and a detection method. The device comprises a surveying ship, an onboard laboratory magnetism measurement portion arranged on the surveying ship, an aerostat shell and an aerostat magnetism measurement portion arranged inside the aerostat shell, wherein the aerostat shell is connected to the surveying ship via a rope, and the aerostat shell floats in air; the aerostat magnetism measurement portion comprises a magnetic sensor, an electronic magnetism data acquisition unit and an aerostat transmission unit; and, the onboard laboratory magnetism measurement portion comprises a data recording computer and a laboratory transmission unit. The marine magnetism detection device and method of the present invention will not be limited by the working sea area and can also operate with other onboard devices and dragging devices.

Abstract: In one embodiment, the present invention provides methods of modulating the deacetylase activity of SIRT1 in one or more cell by modifying the binding affinity of lamin A to SIRT1 via one or more interaction modifying compound. In another embodiment, the present invention provides methods of screening SIRT1-activating/inhibiting compounds based on the interaction between lamin A and SIRT1 proteins and SIRT1-activating property of lamin A. In another embodiment, the present invention provides uses of SIRT1-activating compounds to treat patient(s) suffering from metabolic and/or aging-related degenerative diseases, and uses of SIRT1-inhibiting compounds to treat human malignancies.

Abstract: A method and device for publishing at least one message and a storage medium is provided. The method includes the following steps. A first message published by a first session account in a first session of an instant messaging client is acquired, and session accounts participating in the first session include at least three session accounts containing the first session account, and the first message is used for allowing reply information of at least one reply of at least one session account participating in the first session to the first message to be displayed in the first message. And the first message is displayed in the first session.